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Specialty: Neurology
Condition: Stroke
Cancer: Brain Cancers

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Total 371 results found since Jan 2013.

Brain magnetic resonance in status epilepticus: A focused review
Status epilepticus (SE) results from a defect in seizure termination mechanisms or from the development of events that lead to an abnormally prolonged seizure. The treatment should be started in around 5minutes for tonic-clonic convulsive seizures and in 10minutes for focal SE with impaired consciousness [1]. Central nervous system tumor or infection, stroke, low antiepileptic levels, alcohol withdrawal and metabolic derangement are the most frequent causes. Unfortunately, some cases remain of unknown etiology despite thorough investigation [2].
Source: Seizure: European Journal of Epilepsy - April 21, 2016 Category: Neurology Authors: Amélia Mendes, Luísa Sampaio Tags: Review Source Type: research

Neurocognitive Deficits and Neurocognitive Rehabilitation in Adult Brain Tumors
Opinion statement Neurocognitive deficits are common with brain tumors. If assessed at presentation using detailed neurocognitive tests, problems are detected in 80 % of cases. Neurocognition may be affected by the tumor, its treatment, associated medication, mood, fatigue, and insomnia. Interpretation of neurocognitive problems should be considered in the context of these factors. Early post-operative neurocognitive rehabilitation for brain tumor patients will produce rehabilitation outcomes (e.g., quality of life, improved physical function, subjective neurocognition) equivalent to stroke, multiple sclerosis, ...
Source: Current Treatment Options in Neurology - April 4, 2016 Category: Neurology Source Type: research

Isolated Tongue Hemi-Atrophy from Hypoglossal-Vertebral Entrapment Syndrome (P3.377)
Conclusion: Hypoglossal vertebral entrapment syndrome from a structural vascular anomaly or anomalous vascular course is an extremely rare cause of isolated hypoglossal nerve palsy. Only a few cases have been reported in the literature. Imaging studies and careful exclusion of other potential etiologies is essential to establish the diagnosis.Disclosure: Dr. Roy has nothing to disclose. Dr. Bakradze has nothing to disclose. Dr. Ollenschleger has nothing to disclose. Dr. Felice has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Roy, B., Bakradze, E., Ollenschleger, M., Felice, K. Tags: General Neurology Source Type: research

Pre-Mixing tPA: Moving Past Gestalt (P2.303)
Conclusions: While pre-mixing tPA does not incur financial risk as drug manufacturers replace unused vials without cost, stroke centers remain wary of wasting the drug. We believe succinct criteria can reduce avoidable tPA waste, allowing health care providers to remain fiscally responsible while ensuring AIS patients are treated as fast as possible.Disclosure: Dr. McCarthy has nothing to disclose. Dr. Caputo has nothing to disclose. Dr. Whaley has received personal compensation for activities with Clinical Data Management/Neurobase and Genentech. Dr. Fanale has received personal compensation for activities with Genentech,...
Source: Neurology - April 3, 2016 Category: Neurology Authors: McCarthy, K., Caputo, L., Whaley, M., Fanale, C., Bar-Or, D. Tags: Acute Therapy: IV t-PA Source Type: research

Collaborative, Co-Located Neurology-Primary Care: Maximizing Value Utilizing Curbside, Electronic, and Traditional Consultations (P3.398)
Conclusions: The model of collaborative, co-located neurology care in a primary care practice setting offers a promising intervention to deliver high value, community-based neurology care.Disclosure: Dr. Young has nothing to disclose. Dr. Elrashidi has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Young, N., Elrashidi, M. Tags: General Neurology: Clinical Practice Source Type: research

Diagnostic and Management Challenges in Patients with Left Atrial Myxoma (P1.229)
Conclusions:Cardiac myxomas are rare tumors, mostly arising from the left atrium that may cause ischemic or hemorrhagic strokes, intracranial aneurysms, or myxomatous metastases.Disclosure: Dr. Orjuela has nothing to disclose. Dr. McGinley has nothing to disclose. Dr. Sweis has nothing to disclose. Dr. Prabhu has nothing to disclose. Dr. Bakhos has nothing to disclose. Dr. Biller has received personal compensation in an editorial capacity for the Journal of Stroke and Cerebrovascular Diseases, Frontier in Neurology and Up-To-Date.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Orjuela, K., McGinley, M., Sweis, R., Prabhu, V., Bakhos, M., Biller, J. Tags: Cardiac Mechanisms and Complications of Stroke Source Type: research

A Case of Multiple Recurrent Ischemic Stroke in a Patient with Cholangiocarcinoma and Initiation of Anticoagulation Therapy for Secondary Stroke Prevention (P4.342)
CONCLUSIONS: Initiation of anticoagulation therapy and the optimal medications for secondary stroke prevention in cancer associated stroke remain controversial. Further randomized prospective studies are needed to establish treatment guidelines.Disclosure: Dr. Cheng has nothing to disclose. Dr. Then has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Cheng, J. Z., Then, R. Tags: Cerebrovascular Case Reports Source Type: research

Stroke Subtypes and Risk Factors in Saudi Arabia (P1.124)
CONCLUSION: Non-cardioembolic disease was the overwhelming stroke mechanism in this middle-eastern cohort with only 4[percnt] of patients have cardioembolic stroke, in comparison to roughly 20[percnt] reported in Western cohorts. In part, these differences may be explained by deficient prolonged cardiac monitoring. However the high prevalence of atherothrombotic risk factors and overrepresentation of non-cardioembolic stroke suggests a need to optimize atherothrombotic stroke risk factor management within our populationDisclosure: Dr. Al Harbi has nothing to disclose. Dr. Shoamanesh has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Al Harbi, A., Shoamanesh, A. Tags: Cerebrovascular Disease: Epidemiology Source Type: research

Status Epilepticus in Patients with SMART (P5.012)
CONCLUSIONS We describe three patients with SMART presenting with SE. Our cases raise the concern that SMART is not necessarily a migraine phenomenon but can be a form of focal SE associated with stroke-like symptoms. In patients with radiographic suspicion of SMART we suggest a low threshold for vEEG monitoring and aggressive anti-epileptic management.Disclosure: Dr. Fan has nothing to disclose. Dr. Gabriel has nothing to disclose. Dr. Gerard has nothing to disclose. Dr. Schuele has received personal compensation for activities with Sunovion and Eisai as a speaker.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Fan, P., Gabriel, H., Gerard, E., Schuele, S. Tags: Neuromuscular Disease and Epilepsy ePoster Session Source Type: research

Platelet-Activating Factor Receptor (PAFR) plays a crucial role in experimental global cerebral ischemia and reperfusion.
hid MA Abstract Stroke is one of the most frequent causes of death and disability worldwide leading to a significant clinical and socioeconomic burden. Although different mechanisms are involved in the pathogenesis of stroke, inflammatory response occurs after ischemia and contributes to the expansion of brain injury. Platelet-activating factor receptor (PAF) plays crucial roles in both physiological and pathological conditions in the brain. PAF receptor (PAFR) may be expressed on cellular and nuclear membranes of various cell types, especially leukocytes, platelets, endothelial cells, neuronal cells and microglia...
Source: Brain Research Bulletin - March 30, 2016 Category: Neurology Authors: de Brito Toscano EC, Costa Silva B, Constaza Gómez Victoria E, de Souza Cardoso AC, de Miranda AS, Sugimoto MA, Sousa LP, de Carvalho BA, Kangussu LM, da Silva DG, Rodrigues FG, da Silva Barcelos L, Vasconcelos AC, Amaral FA, Teixeira MM, Teixeira AL, Ra Tags: Brain Res Bull Source Type: research

Proteostasis impairment in ALS.
Abstract In physiological conditions the maintenance of the cellular proteome is a prerequisite for optimal cell functioning and cell survival. Additionally, cells need to constantly sense and adapt to their changing environment and associated stressors. Cells achieve this via a set of molecular chaperones, protein clearance pathways as well as stress-associated signaling networks which work together to prevent protein misfolding, its aggregation and accumulation in subcellular compartments. These processes together form the proteostasis network which helps in maintaining cellular proteostasis. Imbalance or impair...
Source: Brain Research - March 27, 2016 Category: Neurology Authors: Ruegsegger C, Saxena S Tags: Brain Res Source Type: research

Pseudotumoral presentation of cerebral amyloid angiopathy-related inflammation
Conclusion: The identification of one or several nonenhancing space-occupying lesions, especially in elderly patients presenting with cognitive impairment, should raise suspicion for the pseudotumoral presentation of CAA-I and lead to T2*-GRE sequences. Perfusion MRI and MRS appear to be useful techniques for the differential diagnosis of this entity.
Source: Neurology - March 7, 2016 Category: Neurology Authors: Ronsin, S., Deiana, G., Geraldo, A. F., Durand-Dubief, F., Thomas-Maisonneuve, L., Formaglio, M., Desestret, V., Meyronet, D., Nighoghossian, N., Berthezene, Y., Honnorat, J., Ducray, F. Tags: MRI, MRS, Other cerebrovascular disease/ Stroke, Primary brain tumor ARTICLE Source Type: research

Chapter 17 Rehabilitation of patients with glioma
Publication date: 2016 Source:Handbook of Clinical Neurology, Volume 134 Author(s): Mary Vargo, Roger Henriksson, Pär Salander Disabling sequelae occur in a majority of patients diagnosed with brain tumor, including glioma, such as cognitive deficits, weakness, and visual perceptual changes. Often, multiple impairments are present concurrently. Healthcare staff must be aware of the “biographic disruption” the patient with glioma has experienced. While prognostic considerations factor into rehabilitation goals and expectations, regardless of prognosis the treatment team must offer cohesive support, facilitating ho...
Source: Handbook of Clinical Neurology - March 4, 2016 Category: Neurology Source Type: research

Emergent properties of neural repair: Elemental biology to therapeutic concepts
This article is protected by copyright. All rights reserved.
Source: Annals of Neurology - February 29, 2016 Category: Neurology Authors: S. Thomas Carmichael, Clifford Saper, Gottfried Schlaug Tags: Review Source Type: research

Cerebral perfusion in stroke-like migraine attacks after radiation therapy syndrome
We present 2 patients with recurrent attacks of SMART syndrome with increased cerebral blood volume in affected regions and abnormal vascular reactivity on transcranial Doppler ultrasound, suggesting a potential mechanism.
Source: Neurology - February 22, 2016 Category: Neurology Authors: Olsen, A. L., Miller, J. J., Bhattacharyya, S., Voinescu, P. E., Klein, J. P. Tags: MRI, All Clinical Neurology, All Cerebrovascular disease/Stroke, Radiation therapy-tumor CLINICAL/SCIENTIFIC NOTES Source Type: research