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Carnosol Inhibits Cerebral Ischemia-Reperfusion Injury by Promoting AMPK Activation
CONCLUSION: Carnosol has a protective effect on ischemic stroke, and this effect is achieved through AMPK activation. Our study demonstrates the protective effect of carnosol on cerebral ischemia-reperfusion injury and provides a new perspective for the clinical treatment of ischemic stroke.PMID:36775042 | DOI:10.1016/j.brainresbull.2023.02.003
Source: Brain Research Bulletin - February 12, 2023 Category: Neurology Authors: Wen-Chang Xiao Gang Zhou Lu Wan Jun Tu Yong-Jie Yu Zhi-Gang She Chun-Lin Xu Lei Wang Source Type: research

PHLDA1 knockdown alleviates mitochondrial dysfunction and endoplasmic reticulum stress-induced neuronal apoptosis via activating PPAR γ in cerebral ischemia-reperfusion injury
Brain Res Bull. 2023 Jan 18;194:23-34. doi: 10.1016/j.brainresbull.2023.01.007. Online ahead of print.ABSTRACTMitochondrial dysfunction and endoplasmic reticulum (ER) stress occur in ischemic stroke. The disruption of these two organelles can directly lead to cell death through various signaling pathways. Thus, investigation of the associated molecular mechanisms in cerebral ischemia is a prerequisite for stroke treatment. Pleckstrin homology-like domain family A member 1 (PHLDA1) is a multifunctional protein that can modulate mitochondrial function and ER stress in cardiomyocyte and cancer cells. This work studied the rol...
Source: Brain Research Bulletin - January 21, 2023 Category: Neurology Authors: Yushuang Liu Hanshu Zhao Nan Chen Yuelong Li Zeyang Zheng Zhiyu Sun Zhongling Zhang Source Type: research

α7 nicotinic acetylcholine receptor agonist improved brain injury and impaired glucose metabolism in a rat model of ischemic stroke
AbstractVagus nerve stimulation through the action of acetylcholine can modulate inflammatory responses and metabolism. α7 Nicotinic Acetylcholine Receptor (α7nAChR) is a key component in the biological functions of acetylcholine. To further explore the health benefits of vagus nerve stimulation, this study aimed to investigate whether α7nAChR agonists offer beneficial effects against poststroke inflammatory and m etabolic changes and to identify the underlying mechanisms in a rat model of stroke established by permanent cerebral ischemia. We found evidence showing that pretreatment with α7nAChR agonist, GTS-21, improv...
Source: Metabolic Brain Disease - January 20, 2023 Category: Neurology Source Type: research

Diindolylmethane Ameliorates Ischemic Stroke-Induced Brain Injury by Peripheral and Central Mechanisms
CONCLUSION: This inhibition of platelet aggregation, platelet mediated oxidative stress, and inflammation, improved blood flow, and reduced neurological deficits, brain infarction, BBB leakage, brain water content, and histopathological abnormalities indicate the preservation of brain structural integrity. Therefore, these findings conclude that DIM exhibits neuroprotection by inhibiting platelet aggregation. Thus, the present study provided preclinical evidence of DIM neuroprotection against ischemic stroke.PMID:36397630 | DOI:10.2174/1567202620666221116161128
Source: Current Neurovascular Research - November 18, 2022 Category: Neurology Authors: Ramakrishna Kakarla Sushil Kumar Singh Sairam Krishnamurthy Source Type: research

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