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Condition: Ischemic Stroke
Cancer: Brain Cancers
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Total 832 results found since Jan 2013.
Effects of electroacupuncture on the functionality of NG2-expressing cells in perilesional brain tissue of mice following ischemic stroke
Neural Regen Res. 2022 Jul;17(7):1556-1565. doi: 10.4103/1673-5374.330611.ABSTRACTNeural/glial antigen 2 (NG2)-expressing cells has multipotent stem cell activity under cerebral ischemia. Our study examined the effects of electroacupuncture (EA) therapy (2 Hz, 1 or 3 mA, 20 minutes) at the Sishencong acupoint on motor function after ischemic insult in the brain by investigating the rehabilitative potential of NG2-derived cells in a mouse model of ischemic stroke. EA stimulation alleviated motor deficits caused by ischemic stroke, and 1 mA EA stimulation was more efficacious than 3 mA EA stimulation or positive control trea...
Source: Cell Research - December 17, 2021 Category: Cytology Authors: Hong Ju Lee Da Hee Jung Nam Kwen Kim Hwa Kyoung Shin Byung Tae Choi Source Type: research
Inducible Prostaglandin E Synthase as a Pharmacological Target for Ischemic Stroke
In this study, blockade of mPGES-1 by our several novel compounds abolished the lipopolysaccharide (LPS)-induced PGE2 and pro-inflammatory cytokines interleukin 1 β (IL-1β), IL-6, and tumor necrosis factor α (TNF-α) in mouse primary brain microglia. Inhibition of mPGES-1 also decreased PGE2 produced by neuronal cells under oxygen –glucose deprivation (OGD) stress. Among the five enzymes for PGE2 biosynthesis, mPGES-1 was the most induced one in cerebral ischemic lesions. Systemic treatment with our lead compound MPO-0063 (5 or 10 mg/kg, i.p.) in mice after transient middle cerebral artery occlusion (MCAO) improved ...
Source: Neurotherapeutics - January 31, 2022 Category: Neurology Source Type: research
Chronic cerebral hypoperfusion and blood-brain barrier disruption in uninjured brain areas of rhesus monkeys subjected to transient ischemic stroke
J Cereb Blood Flow Metab. 2022 Feb 9:271678X221078065. doi: 10.1177/0271678X221078065. Online ahead of print.ABSTRACTBlood-brain barrier (BBB) disruption is a pivotal pathophysiological process in ischemic stroke. Although temporal changes in BBB permeability during the acute phase have been widely studied, little is known about the chronic phase of cerebrovascular changes that may have a large impact on the long-term outcome. Therefore, this study was aimed to measure cerebral vascular abnormalities using CT perfusion in nine rhesus monkeys subjected to transient middle cerebral artery occlusion (tMCAO) for ≥1 year (MCA...
Source: Cancer Control - February 9, 2022 Category: Cancer & Oncology Authors: Yingqian Zhang Bangcheng Zhao Qi Lai Qinxi Li Xun Tang Yinbing Zhang Zhixiang Pan Qiang Gao Zhihui Zhong Source Type: research
Acute ischemic stroke secondary to ventriculoperitoneal shunt dysfunction in a child with Moyamoya syndrome
CONCLUSION: Children who receive RT for brain tumor, particularly if the circle of Willis region is involved, require close surveillance for the development of vasculopathy and consequent stroke. This surveillance must be even tighter if the patient has been treated with ventricular shunt for the possible synergistic interaction between the two causes on reducing cerebral perfusion and increasing the risk of acute ischemic events.PMID:35928308 | PMC:PMC9345112 | DOI:10.25259/SNI_434_2022
Source: Surgical Neurology International - August 5, 2022 Category: Neurosurgery Authors: Francesca Vitulli Pietro Spennato Domenico Cicala Giuseppe Mirone Maria Rosaria Scala Giuseppe Cinalli Source Type: research
Design and synthesis of novel indole and indazole-piperazine pyrimidine derivatives with anti-inflammatory and neuroprotective activities for ischemic stroke treatment
In conclusion, 5j has the potential for the treatment of stroke as an anti-inflammatory and neuroprotective agent.PMID:35931005 | DOI:10.1016/j.ejmech.2022.114597
Source: European Journal of Medicinal Chemistry - August 5, 2022 Category: Chemistry Authors: Hongwei Wang Enjing Cui Jiaming Li Xiaodong Ma Xueyang Jiang Shuaishuai Du Shihu Qian Le Du Source Type: research
Acute ischemic stroke secondary to ventriculoperitoneal shunt dysfunction in a child with Moyamoya syndrome
CONCLUSION: Children who receive RT for brain tumor, particularly if the circle of Willis region is involved, require close surveillance for the development of vasculopathy and consequent stroke. This surveillance must be even tighter if the patient has been treated with ventricular shunt for the possible synergistic interaction between the two causes on reducing cerebral perfusion and increasing the risk of acute ischemic events.PMID:35928308 | PMC:PMC9345112 | DOI:10.25259/SNI_434_2022
Source: Surgical Neurology International - August 5, 2022 Category: Neurosurgery Authors: Francesca Vitulli Pietro Spennato Domenico Cicala Giuseppe Mirone Maria Rosaria Scala Giuseppe Cinalli Source Type: research
