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Stroke Subtypes and Risk Factors in Saudi Arabia (P1.124)
CONCLUSION: Non-cardioembolic disease was the overwhelming stroke mechanism in this middle-eastern cohort with only 4[percnt] of patients have cardioembolic stroke, in comparison to roughly 20[percnt] reported in Western cohorts. In part, these differences may be explained by deficient prolonged cardiac monitoring. However the high prevalence of atherothrombotic risk factors and overrepresentation of non-cardioembolic stroke suggests a need to optimize atherothrombotic stroke risk factor management within our populationDisclosure: Dr. Al Harbi has nothing to disclose. Dr. Shoamanesh has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Al Harbi, A., Shoamanesh, A. Tags: Cerebrovascular Disease: Epidemiology Source Type: research

Proteostasis impairment in ALS.
Abstract In physiological conditions the maintenance of the cellular proteome is a prerequisite for optimal cell functioning and cell survival. Additionally, cells need to constantly sense and adapt to their changing environment and associated stressors. Cells achieve this via a set of molecular chaperones, protein clearance pathways as well as stress-associated signaling networks which work together to prevent protein misfolding, its aggregation and accumulation in subcellular compartments. These processes together form the proteostasis network which helps in maintaining cellular proteostasis. Imbalance or impair...
Source: Brain Research - March 27, 2016 Category: Neurology Authors: Ruegsegger C, Saxena S Tags: Brain Res Source Type: research

Chronic Elevation of Tumor Necrosis Factor-{alpha} Mediates the Impairment of Leptomeningeal Arteriogenesis in db/db Mice Basic Sciences
Conclusions— These results indicate that leptomeningeal arteriogenesis is impaired in db/db mice and that suppression of the tumor necrosis factor-α response to hypoperfusion is the major contributing factor.
Source: Stroke - May 22, 2015 Category: Neurology Authors: Yukami, T., Yagita, Y., Sugiyama, Y., Oyama, N., Watanabe, A., Sasaki, T., Sakaguchi, M., Mochizuki, H., Kitagawa, K. Tags: Cerebrovascular disease/stroke, Type 2 diabetes, Other Vascular biology Basic Sciences Source Type: research

Atypical isolated nuclear oculomotor nerve syndrome: A diagnostic challenge (P1.031)
CONCLUSION: This report will raise the awareness about nuclear oculomotor nerve syndrome and lead to a potentially successful therapeutic approach.Disclosure: Dr. Liao has nothing to disclose. Dr. Kamiya Matsuoka has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Kamiya Matsuoka, C., Liao, B. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

Rosmarinic acid protects against experimental diabetes with cerebral ischemia: relation to inflammation response
Conclusion: These data show that RA protects the brain against I/R injury with a favorable therapeutic time-window by alleviating diabetic cerebral I/R injury and attenuating blood--brain barrier (BBB) breakdown, and its protective effects may involve HMGB1 and the NF-kappaB signaling pathway.
Source: Journal of Neuroinflammation - February 17, 2013 Category: Neurology Authors: Haiyun LuanZechun KanYong XuChangjun LvWanglin Jiang Source Type: research

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