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MET Inhibits the Proliferation of EC Cells by Increasing MPA Sensitivity
CONCLUSIONS: MET inhibited the proliferation of EC cells by increasing MPA-sensitivity, which was dependent on the inhibition of the CD133 expression and the Akt/mTOR pathway. In addition, if MET acts as an effective progestin sensitizer, it certainly offers promising therapeutic prospects for patients with early-stage EC or overgrown endometrium who have fertility requirements.PMID:37171945
Source: Alternative Therapies in Health and Medicine - May 12, 2023 Category: Complementary Medicine Authors: Fang Sun Jiayun Zhou Yongxin Hao Lei Kuang Bei Zhang Source Type: research

Corrigendum to "Aberrant upregulation of CDK1 contributes to medroxyprogesterone acetate (MPA) resistance in cancer-associated fibroblasts of the endometrium" Biochem. Biophys. Res. Commun. 628 (2022) 133-140
Biochem Biophys Res Commun. 2022 Dec 31:S0006-291X(22)01736-3. doi: 10.1016/j.bbrc.2022.12.065. Online ahead of print.NO ABSTRACTPMID:36593136 | DOI:10.1016/j.bbrc.2022.12.065
Source: Biochemical and Biophysical Research communications - January 2, 2023 Category: Biochemistry Authors: Intan Sofia Omar Noor Azmi Mat Adenan Alejandro Godoy Ik Hui Teo Yogeeta Gunasagran Ivy Chung Source Type: research

Oncological outcomes in fertility-sparing treatment in stage IA-G2 endometrial cancer
ConclusionsConservative measures must be considered temporary to allow pregnancy and subsequently perform specific counseling to adopt surgery. Fertility-sparing management is not the current standard of care for young women with EC. It can be employed for patients with early-stage diseases motivated to maintain reproductive function. Indeed, the results are encouraging, but the sample size must be increased.
Source: Frontiers in Oncology - September 16, 2022 Category: Cancer & Oncology Source Type: research

Aberrant upregulation of CDK1 contributes to medroxyprogesterone acetate (MPA) resistance in cancer-associated fibroblasts of the endometrium
In this study, three benign-associated fibroblasts (BAFs) and four cancer-associated fibroblasts (CAFs) were isolated from human benign and cancerous endometrial tissues, respectively, to examine MPA activation on PR signaling. PR-B protein expression were heterogeneously expressed in both CAFs and BAFs, despite a lower mRNA expression in the former. In a luciferase reporter assay, MPA treatment stimulated some PR DNA-binding activity in BAFs but not in CAFs. Yet, activation of PR target gene was generally more pronounced in MPA-treated CAFs compared to BAFs. Cyclin-dependent kinase 1 (CDK1) was exclusively upregulated by ...
Source: Biochemical and Biophysical Research communications - September 9, 2022 Category: Biochemistry Authors: Intan Sofia Omar Noor Azmi Mat Adenan Alejandro Godoy Ik Hui Teo Yogeeta Gunasagran Ivy Chung Source Type: research

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