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Cancer: Cancer of the Uterus
Drug: Estradiol
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Total 40 results found since Jan 2013.
The Application of 18F-FES PET in Clinical Cancer Care: A Systematic Review
CONCLUSIONS: [18F]fluoroestradiol PET is not only a convenient and accurate diagnostic imaging tool for detecting ER-expressing lesions in patients with breast and ovarian cancer but also among patients with uterine cancer. [18F]fluoroestradiol PET is a noninvasive predictive and monitoring tool for treatment response and prognosis.PMID:37482660 | DOI:10.1097/RLU.0000000000004760
Source: Clinical Genitourinary Cancer - July 24, 2023 Category: Cancer & Oncology Authors: Ya-Ting Huang Tom Wei-Wu Chen Li-Yu Chen Ya-Yao Huang Yen-Shen Lu Source Type: research
Epirubicin toxicity in rat's ovary and uterus: A protective role of 3-Indolepropionic acid supplementation
Chem Biol Interact. 2023 Feb 21:110414. doi: 10.1016/j.cbi.2023.110414. Online ahead of print.ABSTRACTThe "anthracycline, Epirubicin (EPI)," in managing breast cancer, is highly cytotoxic. Tryptophan-derived 3-indolepropionic acid (3-IPA) decreases oxidative damage, and its prospect of alleviating EPI-induced cytotoxicity was examined in rats' hypothalamus-ovary-uterus axis. Female rats: Control, EPI (2.5 mg/kg), 3-IPA alone (40 mg/kg), EPI+3-IPA (2.5 mg/kg + 20 mg/kg), EPI + 3-IPA2 (2.5 mg/kg + 40 mg/kg) were treated for 28 days. Subsequently, reproductive hormones, oxidative and inflammatory stress biomarkers, and tissue...
Source: Chemico-Biological Interactions - February 23, 2023 Category: Molecular Biology Authors: Solomon E Owumi Grace E Adebisi Oyeronke A Odunola Source Type: research
Protective effect of eicosapentaenoic acid against estradiol valerate-induced endometrial hyperplasia via modulation of NF- κB/HIF-1α/VEGF signaling pathway in rats
CONCLUSIONS: EPA in the used doses provided biochemical and histopathological improvement in EV-induced EH via modulation of NF-κB/HIF-1α/VEGF signaling pathway.PMID:36774993 | DOI:10.1016/j.cbi.2023.110399
Source: Chemico-Biological Interactions - February 12, 2023 Category: Molecular Biology Authors: Walaa Yehia Abdelzaher Mohamed A Ibrahim Marwa Hassan Nashwa Fathy Gamal El-Tahawy Michael Atef Fawzy Heba M Hafez Source Type: research
Ormeloxifene, a selective estrogen receptor modulator, protects against pulmonary hypertension
CONCLUSION: This study demonstrates that ormeloxifene promoted pulmonary 17β-estradiol synthesis, alleviated inflammation, improved the NOX4/HO1/Nrf/PPARγ/PGC-1α axis, and attenuated pulmonary hypertension. It is evidently safe at tested concentrations and may be effectively repurposed for pulmonary hypertension treatment.PMID:36731722 | DOI:10.1016/j.ejphar.2023.175558
Source: European Journal of Pharmacology - February 2, 2023 Category: Drugs & Pharmacology Authors: Adam Olaitan Abdulkareem Priya Tiwari Zahid Rasool Lone Hina Iqbal Satish Gupta Rajesh Kumar Jha Debabrata Chanda Kumaravelu Jagavelu Kashif Hanif Source Type: research
Ameliorating Effect of the Edible Mushroom Hericium erinaceus on Depressive-Like Behavior in Ovariectomized Rats
Biol Pharm Bull. 2022;45(10):1438-1443. doi: 10.1248/bpb.b22-00151.ABSTRACTEstrogen deficiency during menopause causes a variety of neurological symptoms, including depression. The edible Lion's Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (HE), is a medicinal mushroom that has the potential for a neuroprotective effect and ameliorating neurological diseases, such as depression, anxiety, and neurodegenerative diseases. HE contains phytoestrogens, including daidzein and genistein. However, the ameliorating effect of HE on menopausal symptoms is not well understood. Here we investigated the impact of methanol extract...
Source: Biological and Pharmaceutical Bulletin - October 2, 2022 Category: Drugs & Pharmacology Authors: Azliza Mad Anuar Akira Minami Hiroshi Matsushita Kanako Ogino Kosei Fujita Hatsune Nakao Shota Kimura Vikineswary Sabaratnam Kaoru Umehara Yuuki Kurebayashi Tadanobu Takahashi Hiroaki Kanazawa Akihiko Wakatsuki Takashi Suzuki Hideyuki Takeuchi Source Type: research
