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A novel combination therapy of arginine deiminase and an arginase inhibitor targeting arginine metabolism in the tumor and immune microenvironment
This study implied the possibility of L-Norvaline as a modulator of the immune response in cancer and provided a new potential therapy combined with ADI-PEG 20.PMID:37293150 | PMC:PMC10244097
Source: Cell Research - June 9, 2023 Category: Cytology Authors: Pei-Hsuan Ye Chung-Yen Li Hao-Yu Cheng Gangga Anuraga Chih-Yang Wang Feng-Wei Chen Shiang-Jie Yang Kuo-Ting Lee Kwang-Yu Chang Ming-Derg Lai Source Type: research

Advances in delivery methods of < em > Arthrospira platensis < /em > (spirulina) for enhanced therapeutic outcomes
Bioengineered. 2022 Jun;13(6):14681-14718. doi: 10.1080/21655979.2022.2100863.ABSTRACTArthrospira platensis (A. platensis) aqueous extract has massive amounts of natural products that can be used as future drugs, such as C-phycocyanin, allophycocyanin, etc. This extract was chosen because of its high adaptability, which reflects its resolute genetic composition. The proactive roles of cyanobacteria, particularly in the medical field, have been discussed in this review, including the history, previous food and drug administration (FDA) reports, health benefits and the various dose-dependent therapeutic functions that A. pla...
Source: Cell Research - August 10, 2022 Category: Cytology Authors: Omar Ashraf ElFar Nashiru Billa Hooi Ren Lim Kit Wayne Chew Wai Yan Cheah Heli Siti Halimatul Munawaroh Deepanraj Balakrishnan Pau Loke Show Source Type: research

A biotin-modified and H < sub > 2 < /sub > O < sub > 2 < /sub > -activatable theranostic nanoplatform for enhanced photothermal and chemical combination cancer therapy
In this study, a biotin-modified and activatable nanotheranostic system is developed. This system (BPSP/DOX-CyBA) composed of H2O2-sensitive thioketal (TK) linker, hydrophilic biotin-decorated polyethylene glycol (PEG) segment, hydrophobic polycaprolactone (PCL) segment, could self-assemble into (99±1.3) nm nanoparticles and co-deliver H2O2-triggered photosensitizer CyBA and cytotoxic drugs DOX to tumor site. In vitro, DOX and CyBA could release rapidly from nanoparticles, CyBA accumulation in the mitochondria causes mitochondrial damage, leading to mitochondrial dysfunctions,while rising the level of ROS in B16F10 cells,...
Source: European Journal of Pharmaceutics and Biopharmaceutics - June 6, 2022 Category: Drugs & Pharmacology Authors: Chuanjiang Jian Ying Wang Huijun Liu Zongning Yin Source Type: research

Effective Anticancer Therapy by Combination of Nanoparticles Encapsulating Chemotherapeutic Agents and Weak Electric Current
In this study, we applied WEC to tumors and investigated the EPR effect with polyethylene glycol (PEG)-modified doxorubicin (DOX) encapsulated nanoparticles (DOX-NP) administered via intravenous injection into melanoma-bearing mice. The application of WEC resulted in a 2.3-fold higher intratumor accumulation of nanoparticles. WEC decreased the amount of connexin 43 in tumors while increasing its phosphorylation; therefore, the enhancing of intratumor delivery of DOX-NP is likely due to the opening of gap junctions. Furthermore, WEC combined with DOX-NP induced a significant suppression of tumor growth, which was stronger t...
Source: Biological and Pharmaceutical Bulletin - February 3, 2022 Category: Drugs & Pharmacology Authors: Anowara Khatun Mahadi Hasan Mahran Mohamed Abd El-Emam Tatsuya Fukuta Miyuki Mimura Riho Tashima Shintaro Yoneda Shintaro Yoshimi Kentaro Kogure Source Type: research

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