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Total 248 results found since Jan 2013.

Development of Functional Chimeric Nanoparticles by Membrane Fusion of Small Extracellular Vesicles and Drug-Encapsulated Liposomes
Biol Pharm Bull. 2023;46(8):1098-1104. doi: 10.1248/bpb.b23-00135.ABSTRACTSince small extracellular vesicle (sEVs) are involved in cell-to-cell communication via transfer of certain bioactive molecules and have the capability to overcome biological barriers against drug transport, their use as a drug delivery system (DDS) has been demonstrated in treatment of a diverse range of diseases. However, some issues in drug encapsulation have been pointed out, including low encapsulation efficiency and poor reproducibility. It was previously reported that liposomes containing phosphatidylserine (PS) can fuse together in the presen...
Source: Biological and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Tatsuya Fukuta Akina Nishikawa Ami Hiramachi Sachika Yamashita Kentaro Kogure Source Type: research

Role of Vitamin D in Head and Neck Cancer-Immune Function, Anti-Tumour Effect, and Its Impact on Patient Prognosis
This article presents the data in line with increasing clinical credibility.PMID:37299554 | DOI:10.3390/nu15112592
Source: Cancer Control - June 10, 2023 Category: Cancer & Oncology Authors: Katarzyna Starska-Kowarska Source Type: research

Targeting the mitochondrial calcium uniporter inhibits cancer progression and alleviates cisplatin resistance in esophageal squamous cell carcinoma
Int J Oncol. 2023 Jul;63(1):82. doi: 10.3892/ijo.2023.5530. Epub 2023 Jun 2.ABSTRACTCisplatin is the standard chemotherapeutic drug used for the treatment of esophageal squamous cell carcinoma (ESCC). Acquired cisplatin resistance is the primary obstacle to prolonging patient survival time. Here, the therapeutic effects of mitochondrial calcium uniporter (MCU) inhibition on tumor growth and cisplatin resistance in ESCC were assessed. MCU was stably overexpressed or knocked down in three ESCC cell lines and three cisplatin‑resistant ESCC cell lines. Then, proliferation, migration, and mitochondrial membrane potential (MMP...
Source: International Journal of Oncology - June 2, 2023 Category: Cancer & Oncology Authors: Yu Miao Xiaofei Wang Yafang Lai Ying Huang Hua Yin Xiangkun Meng Hao Liu Ruirui Hou Wan Lin Xiaoxu Zhang Xu Zhang Bei Cho Chai Feixiong Zhang Le Guo Shaoqi Yang Source Type: research