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ASAP Treatment of Melanoma by Nano-conjugate-Delivered Wee1 siRNA
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.1c00316
Source: Molecular Pharmaceutics - August 10, 2021 Category: Drugs & Pharmacology Authors: Xueyan Zhang, Anqi Cai, Yan Gao, Yuanfa Zhang, Xingmei Duan, and Ke Men Source Type: research

Lysosome activable polymeric vorinostat encapsulating PD-L1KD for a combination of HDACi and immunotherapy
In this study, we develop PDDS{polyethylene glycol-b-asparaginate(diethylenetriamine-vorinostat), (PEG-b-P[Asp(DET-SAHA)n] PPDS)}encapsulating siRNA-PD-L1to provide micelles siRNA-PD-L1-loaded micelles (siRNA@PPDS). Transmission electron microscope (TEM) images demonstrate that siRNA@PPDS micelles presented spherical morphology with a size of about 120 nm; hydrodynamic data analysis indicates pH sensitivity of siRNA@PPDS micelles. The experiments reveal that siRNA@PPDS micelles could be well uptaken by the tumor cells to silence the expression of PD-L1 protein in a dose-dependent manner; compared with the free SAHA, the SA...
Source: Drug Delivery - May 26, 2021 Category: Drugs & Pharmacology Authors: Fengkun Lu Lei Hou Sizhen Wang Yingjie Yu Yunchang Zhang Linhong Sun Chen Wang Zhiqiang Ma Feng Yang Source Type: research

Ligand Bound Fatty Acid Binding Protein 7 (FABP7) Drives Melanoma Cell Proliferation Via Modulation of Wnt/ β-Catenin Signaling
ConclusionThese results suggest the importance of the interaction between FABP7 and its ligands in melanoma proliferation modulation, and the beneficial implications of therapeutic targeting of FABP7 for melanoma treatment.
Source: Pharmaceutical Research - March 1, 2021 Category: Drugs & Pharmacology Source Type: research

Long non-coding RNA UCA1 mediates proliferation and metastasis of laryngeal squamous cell carcinoma cells via regulating miR-185-5p/HOXA13 axis
CONCLUSIONS: The current findings reveal the important role of lncRNA UCA1/miR-185-5p/HOXA13 regulatory network in LSCC cells, and potentially provide new insights into the pathogenesis of LSCC.PMID:33629307 | DOI:10.26355/eurrev_202102_24845
Source: European Review for Medical and Pharmacological Sciences - February 25, 2021 Category: Drugs & Pharmacology Authors: Y-D Sun Q Liu H-X Yang L Tian J Wang L Zeng X-W Zhou Source Type: research

The anti-melanogenic effects of ellagic acid through induction of autophagy in melanocytes and suppression of UVA-activated α-MSH pathways via Nrf2 activation in keratinocytes.
In conclusion, ellagic acid is an effective skin-whitening agent and might be used as a topical applicant. PMID: 33545118 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - February 2, 2021 Category: Drugs & Pharmacology Authors: Yang HL, Lin CP, Vudhya Gowrisankar Y, Huang PJ, Chang WL, Shrestha S, Hseu YC Tags: Biochem Pharmacol Source Type: research

Volume-regulated chloride channel regulates cell proliferation and is involved in the possible interaction between TMEM16A and LRRC8A in human metastatic oral squamous cell carcinoma cells.
CONCLUSIONS: We have found that VRAC acts to regulate the proliferation of human metastatic OSCC cells and the composition of VRAC may involve in the interactions between TMEM16A and LRRC8A in HST-1 cells. PMID: 33476655 [PubMed - as supplied by publisher]
Source: European Journal of Pharmacology - January 18, 2021 Category: Drugs & Pharmacology Authors: Yoshimoto S, Matsuda M, Kato K, Jimi E, Takeuchi H, Nakano S, Kajioka S, Matsuzaki E, Hirofuji T, Inoue R, Hirata M, Morita H Tags: Eur J Pharmacol Source Type: research

Enhancing anti-melanoma outcomes in mice using novel chitooligosaccharide nanoparticles loaded with therapeutic survivin-targeted siRNA.
In conclusion, PBA-modified COSs can serve as a promising carrier for siRNA delivery in the field of anti-tumor therapy. PMID: 33220463 [PubMed - as supplied by publisher]
Source: European Journal of Pharmaceutical Sciences - November 18, 2020 Category: Drugs & Pharmacology Authors: Liu X, Chen L, Zhang Y, Xin X, Qi L, Jin M, Guan Y, Gao Z, Huang W Tags: Eur J Pharm Sci Source Type: research

Development of a carrier system containing hyaluronic acid and protamine for siRNA delivery in the treatment of melanoma
SummaryThe use of small interfering RNA (siRNA) in melanoma treatment remains limited owing to its biological properties. Herein, we developed a carrier system containing hyaluronic acid and protamine for siRNA delivery. Considering zeta potential and particle size as standards, the ratio of each component in liposome nanoparticles prepared was screened using the control variable method, and siRNA cationic liposome nanoparticles were prepared based on the optimal results obtained. The encapsulation rate of the cationic liposome nanoparticles was measured, and particle morphology was observed. B16F10 cells were treated with...
Source: Investigational New Drugs - August 12, 2020 Category: Drugs & Pharmacology Source Type: research

Values of long noncoding RNA SAMMSON in the clinicopathologic features and the prognostic implications of human gastric cancer.
CONCLUSIONS: LncRNA-SAMMSON played an important role in the development of GC, which might be regarded as a new target for the diagnosis and treatment of GC. PMID: 32572923 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - June 25, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Melanoma Cancer Immunotherapy Using PD-L1 siRNA and Imatinib Promotes Cancer-Immunity Cycle
ConclusionOverall, results revealed that the tumors treated with siPDIN restored the immunity of CTLs by potentially inhibiting the immune checkpoint interactions, suppressed the mTOR signaling pathway and exhibited an enhanced anticancer efficacy in melanoma.
Source: Pharmaceutical Research - May 30, 2020 Category: Drugs & Pharmacology Source Type: research

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