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Basal Cell Carcinoma: Part 1
As the most common human cancer worldwide and continuing to increase in incidence, basal cell carcinoma is associated with significant morbidity and cost. Continued advances in research have refined both our insight and approach to this seemingly ubiquitous disease. This 2-part continuing medical education article will provide a comprehensive and contemporary review of basal cell carcinoma. Part I of this series will describe our current understanding of this disease in regards to epidemiology, cost, clinical and histopathologic presentations, carcinogenesis, natural history, and disease associations.
Source: Journal of the American Academy of Dermatology - May 18, 2018 Category: Dermatology Authors: Michael C. Cameron, Erica Lee, Brian Hibler, Christopher A. Barker, Shoko Mori, Miguel Cordova, Kishwer S. Nehal, Anthony M. Rossi Source Type: research

MELALIB 15: A retrospective observational study of 383  cases of melanoma diagnosed by dermatologists in private practice.
CONCLUSION: In terms of French primary care, dermatologists in private practice play a key role in ensuring early detection and initial management of melanoma. PMID: 32653218 [PubMed - as supplied by publisher]
Source: Annales de Dermatologie et de Cenereologie - July 7, 2020 Category: Dermatology Authors: Lorier Roy E, Gressier L, Marco Bonnet J, Berrissoul E, Benjelloun F, Roudier Pujol C, Moyal Barracco M, Bonnet Got C, L'Association de formation médicale continue Dermatologie Paris XV Tags: Ann Dermatol Venereol Source Type: research

The spectrum of oculocutaneous disease: Part II. Neoplastic and drug-related causes of oculocutaneous disease
There are a multitude of diseases that commonly affect both the skin and the eye. Part II of this 2-part series reviews the oculocutaneous manifestations of neoplasms, both benign and malignant, and adverse drug reactions affecting the skin and the eye. Though rare, a number of neoplasms that primarily involve the skin, such as melanoma and basal cell carcinoma, can metastasize to the eye, leading to permanent damage if not properly treated. In addition, periocular neoplasms can irritate the conjunctiva and lid, reducing a patient's ability to see clearly. Neoplastic diseases, such as xeroderma pigmentosum, Sturge–Weber ...
Source: Journal of the American Academy of Dermatology - April 17, 2014 Category: Dermatology Authors: Antoinette Day, Amanda K. Abramson, Mahir Patel, Richard B. Warren, M. Alan Menter Tags: Continuing Medical Education Source Type: research

Topical pharmacotherapy for skin cancer
Source: Journal of the American Academy of Dermatology - May 13, 2014 Category: Dermatology Authors: Giuseppe Micali, Francesco Lacarrubba, Maria Rita Nasca, Robert A. Schwartz Tags: Continuing Medical Education Source Type: research

Diet in dermatology
The roles of dietary factors in aggravating, preventing, or treating skin diseases are common questions encountered in dermatology practice. Part II of this two-part series reviews dietary modifications that can potentially be utilized in the management of melanoma, chronic urticaria, and psoriasis patients. Specifically, we examine the effect of alcohol consumption and supplementation with vitamins D and E, polyunsaturated fatty acids, selenium, green tea, resveratrol, and lycopene on melanoma risk.
Source: Journal of the American Academy of Dermatology - November 14, 2014 Category: Dermatology Authors: Era Caterina Murzaku, Tara Bronsnick, Babar K. Rao Tags: Continuing medical education Source Type: research

Cutaneous adverse effects of targeted therapies
The last decade has spawned an exciting new era of oncotherapy in dermatology, including the development of targeted therapies for metastatic melanoma and basal cell carcinoma. Along with skin cancer, deregulation of the PI3K-AKT-mTOR and RAS-RAF-MEK-ERK intracellular signaling pathways contributes to tumorigenesis of a multitude of other cancers, and inhibitors of these pathways are being actively studied. Similar to other classes of targeted therapies, cutaneous adverse effects are among the most frequent toxicities observed with mitogen-activated protein kinase pathway inhibitors, PI3K-AKT-mTOR inhibitors, hedgehog sig...
Source: Journal of the American Academy of Dermatology - January 15, 2015 Category: Dermatology Authors: James B. Macdonald, Brooke Macdonald, Loren E. Golitz, Patricia LoRusso, Aleksandar Sekulic Tags: Continuing medical education Source Type: research

Response to: “Evidence on pseudoallergen-free diet for chronic urticaria”
To the Editor: We thank Drs Yeung and Swerlick for their comments on our continuing medical education article “Diet in dermatology: Part II. Melanoma, chronic urticaria, and psoriasis.”1 We agree that the benefits of a pseudoallergen-free diet are controversial. Additionally, a pseudoallergen elimination diet may be of limited utility in the majority of chronic urticaria patients.1,2 Indeed, it is important to emphasize that a recent trial found sensitivity to pseudoallergens in less than 1% of a cohort of 100 patients with chronic urticaria.
Source: Journal of the American Academy of Dermatology - May 19, 2015 Category: Dermatology Authors: Era Caterina Murzaku, Tara Bronsnick, Babar K. Rao Tags: JAAD online Source Type: research

Practical application of new technologies for melanoma diagnosis
The criterion standard for diagnosing cutaneous melanoma continues to be histologic examination. However, classifying some melanocytic lesions by conventional microscopy can be problematic if they exhibit some architectural or morphologic characteristics of both nevus and melanoma. Moreover, histologic appearance does not always predict biologic behavior. There is therefore a need and opportunity to develop new technologies that can facilitate the histologic diagnosis of melanoma and potentially help distinguish lesions with a lesser or greater risk of metastasis.
Source: Journal of the American Academy of Dermatology - May 19, 2015 Category: Dermatology Authors: Jordon March, Matthew Hand, Amanda Truong, Douglas Grossman Tags: Continuing medical education Source Type: research

Familial skin cancer syndromes
Nonmelanoma skin cancers (NMSCs) represent the most common malignancies worldwide, with reported incidence rising each year. Both cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), as well as other NMSCs, represent complex diseases with a combination of environmental and genetic risk factors. In general, hereditary cancer syndromes that increase the risk of NMSC fall under several broad categories: those associated with immunodeficiencies, those that affect skin pigmentation, and those that perturb key molecular pathways involved in the pathogenesis of NMSCs.
Source: Journal of the American Academy of Dermatology - February 17, 2016 Category: Dermatology Authors: Prajakta D. Jaju, Katherine J. Ransohoff, Jean Y. Tang, Kavita Y. Sarin Tags: Continuing medical education Source Type: research

Hereditary melanoma: Update on syndromes and management
Malignant melanoma is considered the most lethal skin cancer if it is not detected and treated during its early stages. About 10% of melanoma patients report a family history of melanoma; however, individuals with features of true hereditary melanoma (ie, unilateral lineage, multigenerational, multiple primary lesions, and early onset of disease) are in fact quite rare. Although many new loci have been implicated in hereditary melanoma, CDKN2A mutations remain the most common. Familial melanoma in the presence of multiple atypical nevi should raise suspicion for a germline CDKN2A mutation.
Source: Journal of the American Academy of Dermatology - February 17, 2016 Category: Dermatology Authors: Efthymia Soura, Philip J. Eliades, Kristen Shannon, Alexander J. Stratigos, Hensin Tsao Tags: Continuing medical education Source Type: research

Pregnancy and melanoma
Malignant melanoma is the most common malignancy during pregnancy, and is diagnosed during childbearing age in approximately one-third of women diagnosed with melanoma. The impact of hormonal changes during pregnancy and from iatrogenic hormones on melanoma is controversial. Women undergo immunologic changes during pregnancy that may decrease tumor surveillance. In addition, hormone receptors are found on some melanomas. In spite of these observations, the preponderance of evidence does not support a poorer prognosis for pregnancy-associated melanomas.
Source: Journal of the American Academy of Dermatology - September 19, 2016 Category: Dermatology Authors: Marcia S. Driscoll, Kathryn Martires, Amy Kalowitz Bieber, Miriam Keltz Pomeranz, Jane M. Grant-Kels, Jennifer A. Stein Tags: Continuing medical education Source Type: research

Exam 3: Alcohol Consumption and Multiple Dysplastic Lesions Increase Risk of Squamous Cell Carcinoma in the Esophagus, Head, and Neck
Source: Gastroenterology - September 28, 2016 Category: Gastroenterology Tags: Continuing Medical Education (CME) Activities Source Type: research