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Cancer: Ovarian Cancer
Drug: Insulin
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Total 184 results found since Jan 2013.
Suppression of hypothalamic-pituitary-gonadal function by linzagolix in benign prostatic hyperplasia and polycystic ovary syndrome animal models
Clin Exp Pharmacol Physiol. 2023 Aug 25. doi: 10.1111/1440-1681.13817. Online ahead of print.ABSTRACTThe hypothalamic-pituitary-gonadal (HPG) axis is an important regulatory mechanism involved primarily in the development and regulation of the reproductive systems. The suppression of the HPG axis by gonadotropin-releasing hormone (GnRH) analogues is expected to be effective for the treatment of sex hormone-dependent diseases, such as endometriosis, uterine fibroid, prostate cancer, benign prostatic hyperplasia (BPH) and polycystic ovary syndrome (PCOS). Despite the established involvement of GnRH signalling in these disord...
Source: Clinical and Experimental Pharmacology and Physiology - August 25, 2023 Category: Drugs & Pharmacology Authors: Motohiro Tezuka Saori Yonekubo-Awaka Yasuaki Tamai Kumi Tsuchioka Kaoru Kobayashi Yu Kuramochi Satoshi Tatemichi Tatsuya Nagasawa Sumiyoshi Kiguchi Source Type: research
PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis
Hum Reprod Update. 2023 Jun 23:dmad015. doi: 10.1093/humupd/dmad015. Online ahead of print.ABSTRACTBACKGROUND: Current knowledge about the consequences of PCOS during the late reproductive years and after menopause is limited.OBJECTIVE AND RATIONALE: We performed a systematic review and meta-analysis of data on the pathophysiology, clinical manifestations, diagnosis, prognosis, and treatment of women ≥45 years of age-peri- or postmenopausal-with PCOS.SEARCH METHODS: Studies published up to 15 April 2023, identified by Entrez-PubMed, EMBASE, and Scopus online facilities, were considered. We included cross-sectional or pro...
Source: Cancer Control - June 24, 2023 Category: Cancer & Oncology Authors: Mercedes Mill án-de-Meer Manuel Luque-Ram írez L ía Nattero-Chávez H éctor F Escobar-Morreale Source Type: research
Randomized trial of exercise on cancer-related blood biomarkers and survival in women with ovarian cancer
CONCLUSIONS: Further studies are needed to determine the clinical significance of exercise-induced changes in cancer-related circulating biomarkers in women with ovarian cancer.PMID:37269192 | DOI:10.1002/cam4.6187
Source: Cancer Control - June 3, 2023 Category: Cancer & Oncology Authors: Brenda Cartmel Fang-Yong Li Yang Zhou Linda Gottlieb Lingeng Lu Reed Mszar Maura Harrigan Jennifer A Ligibel Radhika Gogoi Peter E Schwartz Harvey A Risch Melinda L Irwin Source Type: research
Association between IGFBP1 expression and cancer risk: A systematic review and meta-analysis
CONCLUSION: In this study, compared with individuals at low IGFBP1 expression adjusted for age, smoking status, alcohol intake and so on, risk of the prostate cancer and CRC were decreased among individuals of high IGFBP1 expression. There needs further study to confirm this issue.PMID:37251476 | PMC:PMC10220379 | DOI:10.1016/j.heliyon.2023.e16470
Source: Cancer Control - May 30, 2023 Category: Cancer & Oncology Authors: Biao Zhang Chao-Qun Hong Yi-Wei Lin Yun Luo Tian-Yan Ding Yi-Wei Xu Yu-Hui Peng Fang-Cai Wu Source Type: research
Regulation of SIRT1 in Ovarian Function: PCOS Treatment
Curr Issues Mol Biol. 2023 Mar 2;45(3):2073-2089. doi: 10.3390/cimb45030133.ABSTRACTThe sirtuin family, a group of NAD+-dependent class 3 histone deacetylases (HDACs), was extensively studied initially as a group of longevity genes that are activated in caloric restriction and act in concert with nicotinamide adenine dinucleotides to extend the lifespan. Subsequent studies have found that sirtuins are involved in various physiological processes, including cell proliferation, apoptosis, cell cycle progression, and insulin signaling, and they have been extensively studied as cancer genes. In recent years, it has been found t...
Source: Current Issues in Molecular Biology - March 28, 2023 Category: Molecular Biology Authors: Xinrong Li Yuxu He Shuang Wu Peiwen Zhang Mailin Gan Lei Chen Ye Zhao Lili Niu Shunhua Zhang Yanzhi Jiang Zongyi Guo Jinyong Wang Linyuan Shen Li Zhu Source Type: research
