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Polyamidoamine Dendrimers Functionalized with ZnO-Chitosan Nanoparticles as an Efficient Surface for L-asparaginase Immobilization
In this study, the third-generation polyamidoamine dendrimer was functionalized with a 5-amino-1H-tetrazole heterocycle to load the synthesis enzyme and its surface groups. Then, chitosan was attached to the dendrimer by a suitable linker, and finally, zinc oxide nanoparticles were inserted into dendrimer cavities to increase loading. FTIR, FESEM, TEM, and DLS analysis showed that this new dendrimer has specific branches, and ZnO nanoparticles were spread between the branches and connected with the branches and chitosan biopolymer. Also proved the presence of stabilized L-asparaginase enzyme and ZnO nanoparticles in the de...
Source: Applied Biochemistry and Biotechnology - June 7, 2023 Category: Biochemistry Authors: Sudabeh Iraninasab Ahmad Homaei Elaheh Mosaddegh Masoud Torkzadeh-Mahani Source Type: research

SLED1 Promoting Cell Proliferation and Inhibiting Apoptosis in Acute Myeloid Leukemia: a Study
This study further aimed to determine its role in the regulation of AML progression and its action as a potential biomarker for better prognosis. AML microarray profiles GSE97485 and probe annotation from the Gene Expression Omnibus (GEO) database from the National Center for Biotechnology Information (NCBI) were detected using the GEO2R tool ( http://www.ncbi.nlm.nih.gov/geo/geo2r/ ). The expression of AML was downloaded from the TCGA database ( http://cancergenome.nih.gov/ ). The statistical analysis of the database was processed with R software. Bioinformatic analysis found that lncRNA SLED1 is highly expressed in AML p...
Source: Applied Biochemistry and Biotechnology - March 10, 2023 Category: Biochemistry Authors: Jimo Jian Nana Wang Hongyuan Hao Chenglu Yuan Qian Liu Chunyan Ji Fei Lu Source Type: research

Targeted Venetoclax Therapy in t(11;14) Multiple Myeloma: Real World Data From Seven Hungarian Centers
Pathol Oncol Res. 2022 Feb 28;28:1610276. doi: 10.3389/pore.2022.1610276. eCollection 2022.ABSTRACTDespite the introduction of novel agents, multiple myeloma remains incurable for most patients, necessitating further therapeutic options. Venetoclax, a selective BCL-2 inhibitor, had shown promising results in patients with translocation t(11;14), but questions remain open about its optimal use. We have contacted all Hungarian haematology centers for their experience treating t(11;14) myeloma patients with venetoclax. 58 patients were reported. 37 received venetoclax in the relapsed/refractory setting with few or no other th...
Source: Pathology Oncology Research - March 17, 2022 Category: Pathology Authors: Vir ág Réka Szita G ábor Mikala Andr ás Kozma J ános Fábián Apor Hardi Hussain Alizadeh P éter Rajnics L ászló Rejtő Tam ás Szendrei L ászló Váróczy Zsolt Nagy Árpád Illés Istv án Vályi-Nagy Tam ás Masszi Gergely Varga Source Type: research

Induction-related mortality in adolescents and young adults with acute lymphoblastic leukemia in a resource-limited setting: do treatment-related complications create more impact than disease biology?
CONCLUSION: Our study confirms that ALL patients treated in resource-constrained settings have high rates of IRM, mainly attributed to advanced disease and high tumor burden at diagnosis.PMID:35197368 | DOI:10.5045/br.2021.2021058
Source: Cell Research - February 24, 2022 Category: Cytology Authors: Sergio I Inclan-Alarcon Santiago Riviello-Goya Kevin Teran-De-la-Sancha Oscar M Fierro-Angulo Aldo A Acosta-Medina Roberta Demichelis-Gomez Christianne Bourlon Source Type: research

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