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Case Report: Case Series of Kocuria palustris Bacteremia among Immunocompromised Patients
We present three cases of bacteremia in immunocompromised patients admitted to our hospital; one patient was receiving chemotherapy for gall bladder carcinoma, the second was on maintenance hemodialysis for chronic kidney disease, and the third was receiving chemotherapy for acute myeloid leukemia. All three patients presented with a fever in the setting of neutropenia during the course of treatment with chemotherapy (in Cases 1 and 3) or hemodialysis (in Case 2). The blood culture samples of all the patients had pure isolates of Kocuria species K. palustris, which was identified by matrix assisted laser desorption ionisat...
Source: The American Journal of Tropical Medicine and Hygiene - September 18, 2023 Category: Tropical Medicine Authors: Gerlin Varghese Ashima Jamwal Deepika Sarawat Chinmoy Sahu Sangram Singh Patel Nidhi Tejan Source Type: research

Malignant hypercalcemia revealing a diffuse large B ‐cell lymphoma in a patient with a previous diagnosis of chronic myelomonocytic leukemia: An uncommon hematological coexistence
Key Clinical MessageA 76-year-old patient previously admitted to the cardiology department for replacement of a right ventricular lead on a double-chamber pacemaker was admitted to the internal medicine department 15  days after for bronchopneumopathy. His past medical history was relevant for Type 2 diabetes mellitus, heart failure due to dilated hypokinetic heart disease, transcatheter aortic valve implantation (TAVI), and chronic myelomonocytic leukemia (CMML-0) diagnosed in 2021. Twenty-four hours after ad mission, the patient's general condition deteriorated abruptly, with the onset of drowsiness and psychomotor ret...
Source: Clinical Case Reports - September 4, 2023 Category: General Medicine Authors: Alpha Oumar Diallo, Amelie Marcou, J érémie Lespinasse, Zaida Cordoba‐Sosa, Emmanuel Andrès, Léa Docquier, Noel Lorenzo‐Villalba Tags: CASE REPORT Source Type: research

Pharmacokinetics of ibrutinib in a patient with chronic lymphocytic leukemia on hemodialysis
Clin Nephrol. 2022 Oct 24. doi: 10.5414/CN110859. Online ahead of print.ABSTRACTIbrutinib, an oral Bruton's tyrosine kinase inhibitor, is a key drug for the treatment of chronic lymphocytic leukemia (CLL). It is primarily metabolized by cytochrome P450 3A. However, there are no data on the pharmacokinetics of ibrutinib in patients with severe renal impairment or on hemodialysis (HD). We evaluated the pharmacokinetics of ibrutinib in a patient with CLL undergoing HD. An 84-year-old man on HD was diagnosed with CLL and was started on ibrutinib 140 mg daily. The second day of ibrutinib administration was an HD day, and its pl...
Source: Clinical Nephrology - October 24, 2022 Category: Urology & Nephrology Authors: Toyoji Ohtani Akiko Tani Yuki Namme Rie Namme Maki Hirose Ikuo Shingu Yusuke Kizawa Akira Endo Takeo Yasu Source Type: research

To: Severe hypercalcemia as a form of acute lymphoblastic leukemia presentation in children
We present two cases of patients on chronic hemodialysis with Ralstonia pickettii bacteremia linked to contamination of the dialysis water. Similar cases have been published with links to intravenous fluid administration, medication ampules, and the use of extracorporeal oxygenation membranes, among other factors. The detection of Ralstonia pickettii bacteremia should provoke suspicion and a search for contaminated medical products, fluids, and/or medications.
Source: Revista Brasileira de Terapia Intensiva - July 12, 2016 Category: Intensive Care Source Type: research

Reply to: Severe hypercalcemia as a form of acute lymphoblastic leukemia presentation in children
We present two cases of patients on chronic hemodialysis with Ralstonia pickettii bacteremia linked to contamination of the dialysis water. Similar cases have been published with links to intravenous fluid administration, medication ampules, and the use of extracorporeal oxygenation membranes, among other factors. The detection of Ralstonia pickettii bacteremia should provoke suspicion and a search for contaminated medical products, fluids, and/or medications.
Source: Revista Brasileira de Terapia Intensiva - July 12, 2016 Category: Intensive Care Source Type: research