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Cancer: Colorectal Cancer
Drug: Tamoxifen
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Total 32 results found since Jan 2013.
Potential risk of tamoxifen: gut microbiota and inflammation in mice with breast cancer
CONCLUSION: Tamoxifen treatment significantly altered gut microbiota and increased inflammation in the breast cancer xenograft mice model. This may be related to tamoxifen-induced intestinal epithelial barrier damage and TLR5 up-regulation.PMID:37469407 | PMC:PMC10353877 | DOI:10.3389/fonc.2023.1121471
Source: Cancer Control - July 20, 2023 Category: Cancer & Oncology Authors: Hailong Li Xiufei Gao Yian Chen Mengqian Wang Chuchu Xu Qinghong Yu Ying Jin Jiaqing Song Qi Zhu Source Type: research
EZH2 Expression and Survival for ER+/tamoxifen Treated Breast Cancer Patients with rs2302427 C & gt;G: A Novel Prognostic and Risk Predictive Biomarker
CONCLUSIONS: Three significant findings of the SNP rs.2302427C>G (Asp193His) i.e., protective role against breast cancer, survival advantage in ER+/tamoxifen treated breast cancer patients, and decreased expression due to the presence of mutant GG genotype, suggests considering it as an important prognostic biomarker for a good survival outcome of breast cancer patients treated with ER+/tamoxifen. Compared with other studies, the other SNP rs.3757441T>C was observed to have a protective effect in breast cancer biology but plays an antagonistic role in colorectal cancer (CRC) biology. To our knowledge, this is the fir...
Source: Cell Research - July 12, 2023 Category: Cytology Authors: Nisha Gautam Satbir Kaur Surender Kashyap Source Type: research
Fight Aging! Newsletter, April 18th 2022
In conclusion, our results suggest that SAH extends lifespan by inducing MetR or mimicking its downstream effects. Since the lifespan-extending effects of SAH are conserved in yeast and nematodes, and MetR extends the lifespan of many species, exposure to SAH is expected to have multiple benefits across evolutionary boundaries. Our findings offer the enticing possibility that in humans the benefits of a MetR diet can be achieved by promoting Met reduction with SAH. The use of endogenous metabolites, such as SAH, is considered safer than drugs and other substances, suggesting that it may be one of the most feasible ways to ...
Source: Fight Aging! - April 17, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mice carrying an epithelial deletion of the glucocorticoid receptor NR3C1 develop a higher tumor load in experimental colitis associated cancer
In this study we set out to test this hypothesis using the dextran sulfate sodium - azoxymethane model of colitis-associated cancer. KO mice were found to exhibit a 2-fold higher tumor load but similar incidence and tumor size. Tumors had a higher trend to extend close to the submucosal layer (36% vs. 0%) in NR3C1DIEC mice, and overexpressed Lgr5, Egfr and Myc, consistent with distinct expression of proliferative/stemness markers. Snai1 and Snai2 were upregulated specifically in tumors of NR3C1ΔIEC mice, suggesting enhanced epithelial to mesenchymal transition in the absence of the intestinal epithelial GC receptor. We co...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - October 20, 2021 Category: Physiology Authors: Mar ía Arredondo-Amador Raquel Gonz ález Carlos J Aranda Olga Martinez-Augustin Fermin S ánchez de Medina Source Type: research
