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Cancer: Colorectal Cancer
Drug: Aspirin
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Total 264 results found since Jan 2013.
Current Therapeutics in Primary Sclerosing Cholangitis
J Clin Transl Hepatol. 2023 Oct 28;11(5):1267-1281. doi: 10.14218/JCTH.2022.00068S. Epub 2023 Apr 17.ABSTRACTPrimary sclerosing cholangitis (PSC) is an orphan, cholestatic liver disease that is characterized by inflammatory biliary strictures with variable progression to end-stage liver disease. Its pathophysiology is poorly understood. Chronic biliary inflammation is likely driven by immune dysregulation, gut dysbiosis, and environmental exposures resulting in gut-liver crosstalk and bile acid metabolism disturbances. There is no proven medical therapy that alters disease progression in PSC, with the commonly prescribed u...
Source: Clinical Colorectal Cancer - August 14, 2023 Category: Cancer & Oncology Authors: Natassia Tan John Lubel William Kemp Stuart Roberts Ammar Majeed Source Type: research
Aspirin chemoprevention in colorectal cancer: network meta-analysis of low, moderate, and high doses
CONCLUSION: In this network meta-analysis of RCTs, high-dose aspirin was associated with a reduction in colorectal cancer incidence. However, this was based on a limited number of trials. This study did not show a statistically significant risk reduction in colorectal cancer incidence with mid- or low-dose aspirin.PMID:37499126 | DOI:10.1093/bjs/znad231
Source: The British Journal of Surgery - July 27, 2023 Category: Surgery Authors: Devansh Shah Angelina Di Re James W T Toh Source Type: research
Targeting beta-catenin signaling for prevention of colorectal cancer - Nutraceutical, drug, and dietary options
Eur J Pharmacol. 2023 Jul 20:175898. doi: 10.1016/j.ejphar.2023.175898. Online ahead of print.ABSTRACTProgressive up-regulation of β-catenin signaling is very common in the transformation of colorectal epithelium to colorectal cancer (CRC). Practical measures for opposing such signaling hence have potential for preventing or slowing such transformation. cAMP/PKA activity in colon epithelium, as stimulated by COX-2-generated prostaglandins and β2-adrenergic signaling, boosts β-catenin activity, whereas cGMP/PKG signaling has the opposite effect. Bacterial generation of short-chain fatty acids (as supported by unrefined h...
Source: European Journal of Pharmacology - July 22, 2023 Category: Drugs & Pharmacology Authors: Simon Bernard Iloki Assanga Lidianys Mar ía Lewis Luján Mark F McCarty Source Type: research
Low-dose acetylsalicylic acid for cancer prevention considering risk factors: A retrospective cohort study
CONCLUSIONS: Our results suggest that aspirin intake is associated with a reduced incidence of colorectal, pancreatic, and prostate cancers and lymphomas.PMID:37302674 | DOI:10.1016/j.annepidem.2023.06.002
Source: Annals of Epidemiology - June 11, 2023 Category: Epidemiology Authors: D ídac Florensa Jordi Mateo Francesc Solsona Leonardo Galv án Miquel Mesas Ramon Pi ñol Leonardo Espinosa-Leal Pere Godoy Source Type: research
