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Cancer: Colorectal Cancer
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Total 245 results found since Jan 2013.
Colorectal polyp classification and management of complex polyps for surgeon endoscopists
Can J Surg. 2023 Sep 21;66(5):E491-E498. doi: 10.1503/cjs.011422. Print 2023 Sep-Oct.ABSTRACTSummaryIncreasing familiarity with advanced endoscopic excision techniques allows for more colorectal lesions to be removed without major surgery. Endoscopic excision with negative margins is adequate for most polyps and low-risk T1 cancers. The use of modern polyp classification techniques based on size, morphology and pit pattern by an experienced endoscopist allow for an optical diagnosis of these lesions and can predict, with high accuracy, which lesions contain malignant disease and the level of invasion. A surgeon endoscopist...
Source: Canadian Journal of Surgery - September 21, 2023 Category: Surgery Authors: Garrett G R J Johnson Ramzi Helewa Dana C Moffatt John Gerard Coneys Jason Park Eric Hyun Source Type: research
A novel cuproptosis-related gene prognostic signature in colon adenocarcinoma
This study plans to establish a survival prognosis model for colon adenocarcinoma (COAD) patients based on cuproptosis-related genes (CRGs). We investigated the genetic alterations of CRGs in COAD based on The Cancer Genome Atlas database and validated in the GSE41328 dataset. Our results showed that LIPT1, PDHA1, GLS, and CDKN2A had significantly higher expression in COAD tissues than in normal tissues, while FDX1, DLD, and MTF1 had significantly lower expression in COAD tissues than in normal tissues (|(log2(fold change))| > 2, p < 0.05). DLD (hazard ratio (HR): 0.658; 95% confidence interval (CI): 0.445, 0.974; p ...
Source: Canadian Journal of Physiology and Pharmacology - September 12, 2023 Category: Drugs & Pharmacology Authors: Yongqin Su Kun Zhang Source Type: research
Evaluation of the quality of colonoscopies performed by Alberta North Zone surgeons, family physicians and internists: a quality improvement initiative
CMAJ Open. 2023 Aug 1;11(4):E654-E661. doi: 10.9778/cmajo.20210237. Print 2023 Jul-Aug.ABSTRACTBACKGROUND: In Canada, endoscopy is primarily performed by gastroenterologists and surgeons, and some studies report that colonoscopies performed by nongastroenterologists have more complications and higher rates of future colorectal cancer. Our objective was to determine whether rural-based nongastroenterologist endoscopists are achieving quality benchmarks in colonoscopy.METHODS: This quality improvement initiative prospectively evaluated 6 key performance indicators (KPIs) (cecal intubations, polyp detection [males and females...
Source: cmaj - August 1, 2023 Category: General Medicine Authors: Michael R Kolber Peter J Miles Marcus D Shaw Hilgard Goosen Dereck C M Mok Source Type: research
Inappropriate use of proton pump inhibitor among elderly patients in British Columbia: what are the long-term adverse events?
CONCLUSION: This study revealed a high prevalence of PPI use among elderly populations in BC, Canada. The overutilization of PPIs is often a result of failure to re-evaluate the need for continuation of therapy. Published studies identified signals of serious harm from long-term PPI exposure. Healthcare providers with patients can reverse the relentless expansion of long-term PPI exposure by discussing the expected benefits and potential harms.PMID:37496243 | DOI:10.2174/1574886318666230726124540
Source: Current Drug Safety - July 27, 2023 Category: Drugs & Pharmacology Authors: Mohamed Ben-Eltriki Manik Chhabra Alan Cassels James M Wright Source Type: research
