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Specialty: Nanotechnology
Cancer: Breast Cancer
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Total 23 results found since Jan 2013.
Inhibiting HER3 Hyperphosphorylation in HER2 ‐Overexpressing Breast Cancer through Multimodal Therapy with Branched Gold Nanoshells
A multimodal theranostic nanoplatform to treat breast cancer overexpressing the human epidermal growth factor receptors 2 (HER2) and 3 (HER3) is developed, and consisting of doxorubicin-loaded branched gold nanoshells functionalized with a small interfering RNA against HER3 and the HER2-specific antibody Trastuzumab able to simultaneously combine chemo- and photothermal, RNA silencing and immuno-therapies overcoming chemoresistance and reducing tumor size in vivo. AbstractTreatment failure in breast cancers overexpressing human epidermal growth factor receptor 2 (HER2) is associated mainly to the upregulation of human epid...
Source: Small - August 26, 2023 Category: Nanotechnology Authors: Eva Villar ‐Alvarez,
Irene Golán‐Cancela,
Alberto Pardo,
Brenda Velasco,
Javier Fernández‐Vega,
Adriana Cambón,
Abeer Al‐Modlej,
Antonio Topete,
Silvia Barbosa,
José A. Costoya,
Pablo Taboada Tags: Research Article Source Type: research
Simultaneous Delivery of Doxorubicin and EZH2 ‐Targeting siRNA by Vortex Magnetic Nanorods Synergistically Improved Anti‐Tumor Efficacy in Triple‐Negative Breast Cancer
A novel nanomedicine is synthesized based on Fe3O4 vortex nanorods loaded with doxorubicin (DOX) and EZH2 siRNAs and coated with a macrophage membrane. It shows a preferential tumor enrichment profile, thus leading to highly efficient drug delivery at the tumor site. Combining chemotherapy and gene therapy exhibits synergistic antitumor activity in a preclinical TNBC model. AbstractTriple-negative breast cancer (TNBC), one of the most aggressive types of breast cancer, currently lacks a targeted therapy and has a high clinical recurrence rate. The present study reports an engineered magnetic nanodrug based on Fe3O4 vortex ...
Source: Small - June 28, 2023 Category: Nanotechnology Authors: Yunshu Lu,
Fenfen Gu,
Yuwei Ma,
Ruonan Li,
Yi Luo,
Xianhong Da,
Lan Jiang,
Xiang Li,
Yan Liu Tags: Research Article Source Type: research
Precision Therapy of Recurrent Breast Cancer through Targeting Different Malignant Tumor Cells with a HER2/CD44‐Targeted Hydrogel Nanobot
Schematic illustration of the preparation of a HER2/CD44-targeted hydrogel nanobot (ALPR) by embedding the positively charged bio-responsive, liposome-encapsulated nanoparticles (LPR) formed by cationic liposome DOTAP/DOPE, survivin siRNA, andD-(KLAKLAK)2GGR16 (KLA-R16) into negatively charged Herceptin/hyaluronic acid cross-linked nanohydrogels (Herceptin-HA). AbstractHeterogeneity and drug resistance of tumor cells are the leading causes of incurability and poor survival for patients with recurrent breast cancer. In order to accurately deliver the biological anticancer drugs to different subtypes of malignant tumor cells...
Source: Small - May 8, 2023 Category: Nanotechnology Authors: Juan Chen,
Jinjin Li,
Xiaolu Sun,
Huixia Lu,
Kuai Liu,
Zhenbo Li,
Jianyue Guan,
Huiling Song,
Wei Wei,
Yanhong Ge,
Qiong Fan,
Wei Bao,
Buyong Ma,
Zixiu Du Tags: Research Article Source Type: research
Targeted Nanoparticle for Co ‐delivery of HER2 siRNA and a Taxane to Mirror the Standard Treatment of HER2+ Breast Cancer: Efficacy in Breast Tumor and Brain Metastasis (Small 11/2022)
Breast Cancer TreatmentIn article number2107550, Wassana Yantasee and co-workers develop polymer-decorated mesoporous silica nanoparticles for HER2-positive breast cancer treatment. This patented versatile platform can co-deliver multiple therapeutic classes to ensure that they reach the target cells at the same time to fully realize their synergy. Illustrated herein are nanoparticles with three drug cargos: HER2 antibody, HER2 siRNA, and chemotherapeutic docetaxel.
Source: Small - March 17, 2022 Category: Nanotechnology Authors: Worapol Ngamcherdtrakul,
Daniel S. Bejan,
William Cruz ‐Muñoz,
Moataz Reda,
Husam Y. Zaidan,
Natnaree Siriwon,
Suphalak Marshall,
Ruijie Wang,
Molly A. Nelson,
Justin P. C. Rehwaldt,
Joe W. Gray,
Kullervo Hynynen,
Wassana Yantasee Tags: Cover Picture Source Type: research
IR792-MCN@ZIF-8-PD-L1 siRNA drug delivery system enhances photothermal immunotherapy for triple-negative breast cancer under near-infrared laser irradiation
Despite extensive investigations on photothermal therapy, the clinical application is restricted due to poor stability, low therapeutic efficacy of photothermal therapy agents and its affinity loss in the mult...
Source: Journal of Nanobiotechnology - March 2, 2022 Category: Nanotechnology Authors: Yongmei Wang, Haibo Wang, Yuhua Song, Meng Lv, Yan Mao, Hongming Song, Yuanyuan Wang, Gang Nie, Xiaoyi Liu, Jian Cui and Xueqing Zou Tags: Research Source Type: research
Targeted Nanoparticle for Co ‐delivery of HER2 siRNA and a Taxane to Mirror the Standard Treatment of HER2+ Breast Cancer: Efficacy in Breast Tumor and Brain Metastasis
This research paper describes a new therapeutic candidate based on a nanoparticle that co-delivers siRNA against human epidermal growth factor receptor type 2 (HER2), trastuzumab, and docetaxel to treat advanced HER2+ breast cancer. The nanotherapeutic is more effective and safer than the free drug counterparts. It inhibits drug-resistant orthotopic and brain-metastatic HER2+ breast tumors in mice. AbstractThe first-line treatment of advanced and metastatic human epidermal growth factor receptor type 2 (HER2+) breast cancer requires two HER2-targeting antibodies (trastuzumab and pertuzumab) and a taxane (docetaxel or pacli...
Source: Small - January 27, 2022 Category: Nanotechnology Authors: Worapol Ngamcherdtrakul,
Daniel S. Bejan,
William Cruz ‐Muñoz,
Moataz Reda,
Husam Y. Zaidan,
Natnaree Siriwon,
Suphalak Marshall,
Ruijie Wang,
Molly A. Nelson,
Justin P. C. Rehwaldt,
Joe W. Gray,
Kullervo Hynynen,
Wassana Yantasee Tags: Research Article Source Type: research
Rad51 Silencing with siRNA Delivered by Porous Silicon-Based Microparticle Enhances the Anti-Cancer Effect of Doxorubicin in Triple-Negative Breast Cancer
Source: Journal of Biomedical Nanotechnology - January 2, 2022 Category: Nanotechnology Authors: Wu, Zeliang Zhu, Lin Mai, Junhua Shen, Haifa Xu, Rong Tags: research-article Source Type: research
Multifunctional Nanoparticles Loaded with Vascular Endothelial Growth Factor Inhibitors and MED1 siRNA to Inhibit Breast Cancer Progression by Targeting Tumor-Associated Macrophages and Breast Cancer Cells
Source: Journal of Biomedical Nanotechnology - January 2, 2022 Category: Nanotechnology Authors: Wang, Song Luo, Zifeng Zhou, Xinke Wang, Chong Luo, Yuanwei Yi, Nian Liao, Yu Ling Tags: research-article Source Type: research
Growth inhibitory and anti-metastatic activity of epithelial cell adhesion molecule targeted three-way junctional Delta-5-Desaturase siRNA nanoparticle for breast cancer therapy
Publication date: Available online 12 September 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Harshit Shah, Lizhi Pang, Hongzhi Wang, Dan Shu, Steven Y. Qian, Venkatachalem Sathish
Source: Nanomedicine: Nanotechnology, Biology and Medicine - September 14, 2020 Category: Nanotechnology Source Type: research
EF2-kinase targeted cobalt-ferrite siRNA-nanotherapy suppresses BRCA1-mutated breast cancer
Nanomedicine, Ahead of Print.
Source: Nanomedicine - August 20, 2019 Category: Nanotechnology Authors: Elif Asik Yeliz Akpinar Ayse Caner Nermin Kahraman Tulin Guray Murvet Volkan Constance Albarracin Apar Pataer Banu Arun Bulent Ozpolat Source Type: research
Sterically stabilized siRNA:gold nanocomplexes enhance c-MYC silencing in a breast cancer cell model
Nanomedicine, Ahead of Print.
Source: Future Medicine: Nanomedicine - June 4, 2019 Category: Nanotechnology Authors: Aliscia N Daniels Moganavelli Singh Source Type: research
