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UCP2 inhibition sensitizes breast Cancer cells to therapeutic agents by increasing oxidative stress.
In conclusion, UCP2 could be a therapeutic target in breast cancer, especially in those patients treated with tamoxifen. PMID: 25960046 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - May 7, 2015 Category: Biology Authors: Pons DG, Nadal-Serrano M, Torrens-Mas M, Valle A, Oliver J, Roca P Tags: Free Radic Biol Med Source Type: research

The endogenous zinc finger transcription factor, ZNF24, modulates the angiogenic potential of human microvascular endothelial cells Research Communication
We have previously identified a zinc finger transcription factor, ZNF24 (zinc finger protein 24), as a novel inhibitor of tumor angiogenesis and have demonstrated that ZNF24 exerts this effect by repressing the transcription of VEGF in breast cancer cells. Here we focused on the role of ZNF24 in modulating the angiogenic potential of the endothelial compartment. Knockdown of ZNF24 by siRNA in human primary microvascular endothelial cells (ECs) led to significantly decreased cell migration and invasion compared with control siRNA. ZNF24 knockdown consistently led to significantly impaired VEGF receptor 2 (VEGFR2) signaling ...
Source: FASEB Journal - April 1, 2015 Category: Biology Authors: Jia, D., Huang, L., Bischoff, J., Moses, M. A. Tags: Research Communication Source Type: research

Expression of xCT and activity of system xc− are regulated by NRF2 in human breast cancer cells in response to oxidative stress
Publication date: Available online 18 March 2015 Source:Redox Biology Author(s): Eric Habib , Katja Linher-Melville , Han-Xin Lin , Gurmit Singh Cancer cells adapt to high levels of oxidative stress in order to survive and proliferate by activating key transcription factors. One such master regulator, the redox sensitive transcription factor NF E2 Related Factor 2 (NRF2), controls the expression of cellular defense genes including those encoding intracellular redox-balancing proteins involved in glutathione (GSH) synthesis. Under basal conditions, Kelch-like ECH-associated protein 1 (KEAP1) targets NRF2 for ubiquitinatio...
Source: Redox Biology - March 18, 2015 Category: Biology Source Type: research

Lysophosphatidate signaling stabilizes Nrf2 and increases the expression of genes involved in drug resistance and oxidative stress responses: implications for cancer treatment Research Communication
This study provides the first evidence that LPA increases antioxidant gene and multidrug-resistant transporter expression. Blocking this aspect of LPA signaling provides a novel strategy for improving chemotherapy.—Venkatraman, G., Benesch, M. G. K., Tang, X., Dewald, J., McMullen, T. P. W., Brindley, D. N. Lysophosphatidate signaling stabilizes Nrf2 and increases the expression of genes involved in drug resistance and oxidative stress responses: implications for cancer treatment.
Source: FASEB Journal - March 2, 2015 Category: Biology Authors: Venkatraman, G., Benesch, M. G. K., Tang, X., Dewald, J., McMullen, T. P. W., Brindley, D. N. Tags: Research Communication Source Type: research

Essential role of the cancer stem/progenitor cell marker nucleostemin for indole-3-carbinol anti-proliferative responsiveness in human breast cancer cells
Conclusions: Our results provide the first evidence that a natural anti-cancer compound mediates its cellular and in vivo tumor anti-proliferative responses by selectively stimulating cellular interactions of the stem/progenitor cell marker nucleostemin with MDM2, which frees p53 to trigger its apoptotic response. Furthermore, our study provides a new mechanistic template that can be potentially exploited for the development of cancer stem/progenitor cell targeted therapeutic strategies.
Source: BMC Biology - Latest articles - September 12, 2014 Category: Biology Authors: Antony TinAnna ParkShyam SundarGary Firestone Source Type: research

Target Inhibition Networks: Predicting Selective Combinations of Druggable Targets to Block Cancer Survival Pathways
by Jing Tang, Leena Karhinen, Tao Xu, Agnieszka Szwajda, Bhagwan Yadav, Krister Wennerberg, Tero Aittokallio A recent trend in drug development is to identify drug combinations or multi-target agents that effectively modify multiple nodes of disease-associated networks. Such polypharmacological effects may reduce the risk of emerging drug resistance by means of attacking the disease networks through synergistic and synthetic lethal interactions. However, due to the exponentially increasing number of potential drug and target combinations, systematic approaches are needed for prioritizing the most potent multi-target alter...
Source: PLoS Computational Biology - September 12, 2013 Category: Biology Authors: Jing Tang et al. Source Type: research

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