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Managing Chemotherapy-Related Cardiotoxicity in Survivors of Childhood Cancers.
Abstract In the US, children diagnosed with cancer are living longer, but not without consequences from the same drugs that cured their cancer. In these patients, cardiovascular disease is the leading cause of non-cancer-related morbidity and mortality. Although this review focuses on anthracycline-related cardiomyopathy in childhood cancer survivors, the global lifetime risk of other cardiovascular diseases such as atherosclerosis, arrhythmias and intracardiac conduction abnormalities, hypertension, and stroke also are increased. Besides anthracyclines, newer molecularly targeted agents, such as vascular endothel...
Source: Paediatric Drugs - August 19, 2014 Category: Pediatrics Authors: Lipshultz SE, Diamond MB, Franco VI, Aggarwal S, Leger K, Santos MV, Sallan SE, Chow EJ Tags: Paediatr Drugs Source Type: research

Managing Chemotherapy-Related Cardiotoxicity in Survivors of Childhood Cancers
Abstract In the US, children diagnosed with cancer are living longer, but not without consequences from the same drugs that cured their cancer. In these patients, cardiovascular disease is the leading cause of non-cancer-related morbidity and mortality. Although this review focuses on anthracycline-related cardiomyopathy in childhood cancer survivors, the global lifetime risk of other cardiovascular diseases such as atherosclerosis, arrhythmias and intracardiac conduction abnormalities, hypertension, and stroke also are increased. Besides anthracyclines, newer molecularly targeted agents, such as vascular endothe...
Source: Pediatric Drugs - October 1, 2014 Category: Pediatrics Source Type: research

Severe Cerebral Vasospasm and Childhood Arterial Ischemic Stroke After Intrathecal Cytarabine
We report on 2 patients who developed widespread cerebral vasospasm and arterial ischemic strokes (AIS) after application of intrathecal (IT) cytarabine. In a 3-year-old child with acute lymphoblastic leukemia (ALL), left leg weakness, hyperreflexia, and clonus were noted 4 days after her first dose of IT cytarabine during the induction phase of her chemotherapy. Cerebral MRI revealed multiple acute cerebral ischemic infarcts and widespread cerebral vasospasm. A 5-year-old girl complained of right arm and leg pain and began limping 11 days after IT cytarabine. Symptoms progressed to right dense hemiplegia, left gaze deviat...
Source: PEDIATRICS - February 1, 2016 Category: Pediatrics Authors: Tibussek, D., Natesirinilkul, R., Sun, L. R., Wasserman, B. A., Brandao, L. R., deVeber, G. Tags: Hematology/Oncology, Cancer/Neoplastic, Neurology, Neurologic Disorders Case Report Source Type: research

What is machine learning?
The term machine learning (ML) is emerging more often in the medical literature. There are successful clinical applications of ML with the specialties of ophthalmology and radiology leading the way. For example, in ophthalmology the diagnosis of diabetic retinopathy and retinopathy of prematurity,1 and in radiology the diagnosis of stroke or cancers from digital images is promising.2 This success is expected to expand into other medical disciplines including general paediatrics and its subspecialties. Therefore, healthcare practitioners and researchers are most likely to benefit from getting familiar with ML terminology in...
Source: Archives of Disease in Childhood - Education and Practice - September 19, 2022 Category: Pediatrics Authors: Baloglu, O., Latifi, S. Q., Nazha, A. Tags: Research in practice Source Type: research