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A cost analysis of individualized asparaginase treatment in pediatric acute lymphoblastic leukemia
ConclusionsTDM of asparaginase is cost saving if calculated with the absolute asparaginase dose and will be if the waste is minimalized by preparing multiple doses out of one vial.
Source: Pediatric Blood and Cancer - August 2, 2017 Category: Cancer & Oncology Authors: Robin Q.H. Kloos, Carin A. Uyl ‐de Groot, Raphaële R.L. Litsenburg, Gertjan J.L. Kaspers, Rob Pieters, Inge M. der Sluis Tags: RESEARCH ARTICLE Source Type: research

Allergic‐like reactions to asparaginase: Atypical allergies without asparaginase inactivation
ConclusionsIn conclusion, allergic‐like reactions occur relatively late after the start of infusion and without antibodies. Despite these clinical differences, allergic‐like reactions can only be distinguished from real allergies by continually measuring asparaginase activity levels. If clinically tolerated, formulations should not be switched in case of allergic‐like reactions. Moreover, failure to recognize these reactions may lead to a less favorable prognosis if asparaginase therapy is terminated unnecessarily.
Source: Pediatric Blood and Cancer - July 4, 2016 Category: Cancer & Oncology Authors: Robin Q. H. Kloos, Rob Pieters, Gabriele Escherich, Inge M. der Sluis Tags: Research Article Source Type: research

Allergic ‐like reactions to asparaginase: Atypical allergies without asparaginase inactivation
ConclusionsIn conclusion, allergic‐like reactions occur relatively late after the start of infusion and without antibodies. Despite these clinical differences, allergic‐like reactions can only be distinguished from real allergies by continually measuring asparaginase activity levels. If clinically tolerated, formulations should not be switched in case of allergic‐like reactions. Moreover, failure to recognize these reactions may lead to a less favorable prognosis if asparaginase therapy is terminated unnecessarily.
Source: Pediatric Blood and Cancer - July 3, 2016 Category: Cancer & Oncology Authors: Robin Q. H. Kloos, Rob Pieters, Gabriele Escherich, Inge M. der Sluis Tags: Research Article Source Type: research

Association of atopic diseases and parvovirus B19 with acute lymphoblastic leukemia in childhood and adolescence in the northeast of Brazil
Conclusions These results suggest that atopic diseases and elevated total IgE levels are associated with a potential protective effect on the development of ALL. Previous infection with parvovirus B19 contributed to ALL susceptibility.
Source: International Journal of Clinical Oncology - May 24, 2016 Category: Cancer & Oncology Source Type: research

Polymorphisms of asparaginase pathway and asparaginase-related complications in children with acute lymphoblastic leukemia.
Conclusions:This finding might have implication for treatment individualization in ALL and other cancers employing asparagine depletion strategies. PMID: 24907114 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - June 6, 2014 Category: Cancer & Oncology Authors: Ben Tanfous M, Sharif-Askari B, Ceppi F, Laaribi H, Gagné V, Rousseau J, Labuda M, Silverman LB, Sallan SE, Neuberg D, Kutok JL, Sinnett D, Laverdière C, Krajinovic M Tags: Clin Cancer Res Source Type: research

Reply: Comment on ‘Allergy and acute leukaemia in children with Down syndrome: a population study. Report from the Mexican Inter-Institutional Group for the Identification of the Causes of Childhood Leukaemia (MIGICCL)’ – A reality or myth or two viewpoints about the association between allergies and acute leukaemia in Down syndrome children
Reply: Comment on ‘Allergy and acute leukaemia in children with Down syndrome: a population study. Report from the Mexican Inter-Institutional Group for the Identification of the Causes of Childhood Leukaemia (MIGICCL)’ – A reality or myth or two viewpoints about the association between allergies and acute leukaemia in Down syndrome children British Journal of Cancer advance online publication, August 1 2013. doi:10.1038/bjc.2013.436 Authors: J C Núñez-Enríquez, A Fajardo-Gutiérrez, E P Buchán-Durán, E Jiménez-Hernández & J M Mejía-Aranguré
Source: British Journal of Cancer AOP - August 1, 2013 Category: Cancer & Oncology Authors: J C Núñez-EnríquezA Fajardo-GutiérrezE P Buchán-DuránE Jiménez-HernándezJ M Mejía-Aranguré Source Type: research

Allergies, atopy, immune‐related factors and childhood rhabdomyosarcoma: A report from the children's oncology group
Abstract Rhabdomyosarcoma (RMS) is a highly malignant tumor of developing muscle that can occur anywhere in the body. Due to its rarity, relatively little is known about the epidemiology of RMS. Atopic disease is hypothesized to be protective against several malignancies; however, to our knowledge, there have been no assessments of atopy and childhood RMS. Therefore, we explored this association in a case‐control study of 322 childhood RMS cases and 322 pair‐matched controls. Cases were enrolled in a trial run by the Intergroup Rhabdomyosarcoma Study Group. Controls were matched to cases on race, sex, and age. The foll...
Source: International Journal of Cancer - July 3, 2013 Category: Cancer & Oncology Authors: Philip J. Lupo, Renke Zhou, Stephen X. Skapek, Douglas S. Hawkins, Logan G. Spector, Michael E. Scheurer, M. Fatih Okcu, Beatrice Melin, Karin Papworth, Erik B. Erhardt, Seymour Grufferman Tags: Epidemiology Source Type: research