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Drug: Polyethylene Glycol

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Total 26 results found since Jan 2013.

Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo. « Back to Top Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/ It seems...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A novel intra-tumoral drug delivery carrier for treatment of oral squamous cell carcinoma
This study evaluated a new intra-tumor-targeted drug delivery method for the treatment of OSCC induced on the dorsum of the tongue in white mice. The induced tumors were examined by needle biopsy. A targeted anticancer drug (Cetuximab) and [Cisplatin and 5 Fluorouracil (5-FU)] chemotherapeutic agents were loaded on polyethylene glycol-polylactide-polyethylene glycol (PEG-PLA-PEG) nanoparticles (NPs) designed for intralesional injection while systemic administration was used as control. Fourier transform infrared spectroscopy (FTIR) was performed to study NP chemical structure, a drug release profile was conducted to study ...
Source: Cancer Control - July 26, 2023 Category: Cancer & Oncology Authors: Shimaa A Elsaady Moustafa N Aboushelib Essam Al-Wakeel Manal F Badawi Source Type: research

Mushroom-brush transitional conformation of mucus-inert PEG coating improves co-delivery of oral liposome for intestinal metaplasia therapy
Biomater Adv. 2022 May;136:212798. doi: 10.1016/j.bioadv.2022.212798. Epub 2022 Apr 12.ABSTRACTThe blocking of gastric mucosal intestinal metaplasia (IM) has been considered to be the pivotal method to control the occurrence of gastric cancer. However, there is still a lack of effective therapeutic agent. Here, we developed mucus-penetrating liposome system by covering surface with polyethylene glycol (PEG) chains (hydrophilic and electroneutral mucus-inert material) to co-delivery candidate drugs combination. Then studied the impact on the transmucus performance of different conformations, which were constructed by contro...
Source: Cancer Control - August 5, 2022 Category: Cancer & Oncology Authors: Yuyi Wu Wenjun Wang Ziwei Yu Ke Yang Zecheng Huang Ziqiang Chen Xiaomin Yan Huiling Hu Zhanguo Wang Source Type: research

Low-dose of magnesium sulfate solution was not inferior to standard regime of polyethylene glycol for bowel preparation in elderly patients: a randomized, controlled study
CONCLUSIONS: Low dose of MSS was not inferior to the standard PEG regime in terms of bowel preparation quality for elderly patients. Low-dose MSS offered fewer adverse events and better tolerability. It is a preferable choice for the elderly to undergo bowel preparation for colonoscopy.CLINICAL TRIAL REGISTRATION NUMBER: NCT04948567.PMID:35920250 | DOI:10.1080/00365521.2022.2106154
Source: Cancer Control - August 3, 2022 Category: Cancer & Oncology Authors: Fulin Ge Xiaoyu Kang Zeyu Wang Hailan Zhu Liang Liao Ming Wang Jianjun Jia Lijun Lou Xuegang Guo Yanglin Pan Jun Wan Source Type: research

Top 20 Research Studies of 2021 for Primary Care Physicians
This article summarizes the top 20 research studies of 2021 identified as POEMs (patient-oriented evidence that matters) that did not address the COVID-19 pandemic. Sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists prevent adverse cardiovascular and renal outcomes in patients with type 2 diabetes mellitus and also reduce all-cause and cardiovascular mortality. Most older adults (mean age, 75 years) with prediabetes do not progress to diabetes. Among patients in this age group with type 2 diabetes treated with medication, an A1C level of less than 7% is associated with increased risk of...
Source: American Family Physician - July 15, 2022 Category: Primary Care Authors: Mark H Ebell Roland Grad Source Type: research