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Monoclonal Antibodies Specific for the E2 Glycoprotein of Hepatitis C Virus and Their Use in the Diagnosis, Treatment and Prevention of Hepatitis C
Hepatitis C virus is an enveloped, single stranded RNA virus, approximately 50 nm in diameter, that has been classified as a separate genus in the Flaviviridae family. Most persons infected with hepatitis C virus develop chronic infection. These chronically infected individuals have a relatively high risk of developing chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. There is currently no vaccine to prevent the hepatitis C virus infection. The present invention relates to human monoclonal antibodies which exhibit immunological binding affinity for the hepatitis C virus E2 glycoprotein and are cross-reactive...
Source: NIH OTT Licensing Opportunities - July 6, 2020 Category: Research Authors: ott-admin Source Type: research

Hepatitis B vaccine non-responders: possible mechanisms and solutions
Hepatitis B (HBV) is a viral illness that chronically infects 240 million people worldwide, leads to cirrhotic liver disease, and increases risk of hepatocellular carcinoma. The HBV vaccine has decreased HBV infection and along with human papilloma virus (HPV) vaccine are the only vaccines that prevent cancer. Despite the effectiveness of HBV vaccine, some populations do not develop protective responses. The risk groups for poor response include those with immunosuppression or dialysis-dependent, end-stage renal disease.
Source: Annals of Allergy, Asthma and Immunology - March 19, 2018 Category: Allergy & Immunology Authors: Tara Vinyette Saco, Alexandra T. Strauss, Dennis K. Ledford Tags: Review Source Type: research

Hepatitis B vaccine non-responders: possible mechanisms and solutions.
CONCLUSION: This review will provide a background on the immunology of HBV infection, the possible immunologic mechanisms to explain HBV vaccine non-responsiveness, current research aimed at improving vaccine effectiveness, and possible future approaches for providing non-responders protection from HBV. PMID: 29567355 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - March 19, 2018 Category: Allergy & Immunology Authors: Saco TV, Strauss AT, Ledford DK Tags: Ann Allergy Asthma Immunol Source Type: research

Hepatitis B vaccine nonresponders
Hepatitis B (HBV) is a viral illness that chronically infects 240 million people worldwide, leads to liver disease, and increases risk of hepatocellular carcinoma. The HBV vaccine has decreased HBV infection, and it and the human papilloma virus vaccine are the only vaccines that prevent cancer. Despite the effectiveness of the HBV vaccine, some populations do not develop protective responses. The risk groups for poor response include those with immunosuppression or dialysis-dependent, end-stage renal disease.
Source: Annals of Allergy, Asthma and Immunology - March 19, 2018 Category: Allergy & Immunology Authors: Tara Vinyette Saco, Alexandra T. Strauss, Dennis K. Ledford Tags: Review Source Type: research

Human Leukocyte Antigens Influence the Antibody Response to Hepatitis B Vaccine.
Abstract Hepatitis B virus (HBV) infection and its sequelae such as cirrhosis and hepatocellular carcinoma has remained a serious public health problem throughout the world. The WHO strategy for effective control of HBV infection and its complications is mass vaccination of neonates and children within the framework of Expanded Programme on Immunization (EPI). Vaccination with hepatitis B surface antigen (HBsAg) induces protective antibody response (anti-HBs ≥ 10 IU/L) in 90-99% of vaccinees. The lack of response to HBsAg has been attributed to a variety of  immunological mechanisms, including defect in anti...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2015 Category: Allergy & Immunology Authors: Jafarzadeh A, Bagheri-Jamebozorgi M, Nemati M, Golsaz-Shirazi F, Shokri F Tags: Iran J Allergy Asthma Immunol Source Type: research