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Cancer: Epithelial Cancer
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Total 347 results found since Jan 2013.
Extracellular pyruvate kinase M2 induces cell migration through p-Tyr42 RhoA-mediated superoxide generation and epithelial-mesenchymal transition
Free Radic Biol Med. 2023 Sep 16:S0891-5849(23)00640-8. doi: 10.1016/j.freeradbiomed.2023.09.016. Online ahead of print.ABSTRACTIn the tumor microenvironment (TME), communication between cancer cells and tumor-associated macrophages (TAMs) through secreted extracellular proteins promotes cancer progression. Here, we observed that co-culturing cancer cells (4T1) and macrophage cells (Raw264.7) significantly enhanced superoxide production in both cell types. Using MALDI-TOF, we identified PKM2 as a highly secreted protein by Raw264.7 cells and bone marrow-derived monocytes. The extracellular recombinant PKM2 protein not only...
Source: Free Radical Biology and Medicine - September 18, 2023 Category: Biology Authors: Amir Hamza Jung Yoon Cho Kim Cuong Cap Abu Jubayer Hossain Jae-Gyu Kim Jae-Bong Park Source Type: research
Piezoeletric cold atmospheric plasma induces apoptosis and autophagy in human hepatocellular carcinoma cells through blocking glycolysis and AKT/mTOR/HIF-1 α pathway
Free Radic Biol Med. 2023 Aug 3:S0891-5849(23)00570-1. doi: 10.1016/j.freeradbiomed.2023.07.036. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the sixth most prevalent cancer and the fourth leading cause of cancer-related death worldwide. Advanced or metastatic HCC is currently managed using systemic drug therapy with unsatisfactory patient survival. Cold atmospheric plasma has emerged as a promising, physicochemical, and broad-spectrum oncotherapy. In this preclinical study, we investigated the anti-neoplastic functions and mechanism of piezoelectric direct discharge technology-based CAP, Piezo-CAP, on H...
Source: Free Radical Biology and Medicine - August 5, 2023 Category: Biology Authors: Yanhong Wang Xinyu Mang Danni Li Yiliang Chen Zhenyu Cai Fei Tan Source Type: research
Oncogenic Ras deregulates cell-substrate interactions during mitotic rounding and respreading to alter cell division orientation
Curr Biol. 2023 Jun 13:S0960-9822(23)00723-6. doi: 10.1016/j.cub.2023.05.061. Online ahead of print.ABSTRACTOncogenic Ras has been shown to change the way cancer cells divide by increasing the forces generated during mitotic rounding. In this way, RasV12 enables cancer cells to divide across a wider range of mechanical environments than normal cells. Here, we identify a further role for oncogenic Ras-ERK signaling in division by showing that RasV12 expression alters the shape, division orientation, and respreading dynamics of cells as they exit mitosis. Many of these effects appear to result from the impact of RasV12 signa...
Source: Current Biology - June 21, 2023 Category: Biology Authors: Sushila Ganguli Tom Wyatt Agata Nyga Rachel H Lawson Tim Meyer Buzz Baum Helen K Matthews Source Type: research
Interferon- γ induces salivary gland epithelial cell ferroptosis in Sjogren's syndrome via JAK/STAT1-mediated inhibition of system Xc < sup > < /sup >
Free Radic Biol Med. 2023 Jun 5:S0891-5849(23)00462-8. doi: 10.1016/j.freeradbiomed.2023.05.027. Online ahead of print.ABSTRACTThe elevated level of interferon-γ (IFN-γ) in Sjogren's syndrome (SS) triggers salivary gland epithelial cells (SGEC) death. However, the underlying mechanisms of IFN-γ-induced SGEC death modes are still not fully elucidated. We found that IFN-γ triggers SGEC ferroptosis via Janus kinase/signal transducer and activator of transcription 1 (JAK/STAT1)-mediated inhibition of cystine-glutamate exchanger (System Xc-). Transcriptome analysis revealed that ferroptosis-related markers are differentiall...
Source: Free Radical Biology and Medicine - June 7, 2023 Category: Biology Authors: Tingting Cao Jiannan Zhou Qianwen Liu Tianjiao Mao Bo Chen Qingqing Wu Lijing Wang Janak L Pathak Nobumoto Watanabe Jiang Li Source Type: research
Erianin inhibits the growth and metastasis through autophagy-dependent ferroptosis in KRAS < sup > G13D < /sup > colorectal cancer
Free Radic Biol Med. 2023 May 20:S0891-5849(23)00421-5. doi: 10.1016/j.freeradbiomed.2023.05.008. Online ahead of print.ABSTRACTColorectal cancer (CRC) is the third most common cause of cancer mortality worldwide. Approximately 40% of CRC patients are KRAS sequence variation, including KRAS G13D mutation (KRASG13D) CRC patients, accounting for approximately 8% of all KRAS mutations in CRC patients and showing little benefit from anti-EGFR therapy. Therefore, there is an urgent need for new and effective anticancer agents in patients with KRASG13D CRC. Here, we identified a natural product, erianin, that directly interacted...
Source: Free Radical Biology and Medicine - May 22, 2023 Category: Biology Authors: Qun Miao Wei-Qing Deng Wen-Yu Lyu Zhi-Ting Sun Shu-Ran Fan Ming Qi Sheng-Hui Qiu Yin-Ru Zhu Jia-Peng Lin Min-Feng Chen Li-Juan Deng Source Type: research
Polarity in respiratory development, homeostasis and disease
Curr Top Dev Biol. 2023;154:285-315. doi: 10.1016/bs.ctdb.2023.02.004. Epub 2023 Mar 15.ABSTRACTThe respiratory system is composed of a multitude of cells that organize to form complex branched airways that end in alveoli, which respectively function to guide air flow and mediate gas exchange with the bloodstream. The organization of the respiratory sytem relies on distinct forms of cell polarity, which guide lung morphogenesis and patterning in development and provide homeostatic barrier protection from microbes and toxins. The stability of lung alveoli, the luminal secretion of surfactants and mucus in the airways, and t...
Source: Current Topics in Developmental Biology - April 26, 2023 Category: Biology Authors: Andrew M Tilston-Lunel Xaralabos Varelas Source Type: research
Polarity in breast development and cancer
We describe cell lines, organoids, and in vivo models commonly used for studying apical-basal polarity in breast development and disease and discuss advantages and limitations of each. We also provide examples of how core polarity proteins regulate branching morphogenesis and lactation during development. We describe alterations to core polarity genes in breast cancer and their associations with patient outcomes. The impact of up- or down-regulation of key polarity proteins in breast cancer initiation, growth, invasion, metastasis, and therapeutic resistance are discussed. We also introduce studies demonstrating that polar...
Source: Current Topics in Developmental Biology - April 26, 2023 Category: Biology Authors: Mara K M Whitford Luke McCaffrey Source Type: research
Polarity in respiratory development, homeostasis and disease
Curr Top Dev Biol. 2023;154:285-315. doi: 10.1016/bs.ctdb.2023.02.004. Epub 2023 Mar 15.ABSTRACTThe respiratory system is composed of a multitude of cells that organize to form complex branched airways that end in alveoli, which respectively function to guide air flow and mediate gas exchange with the bloodstream. The organization of the respiratory sytem relies on distinct forms of cell polarity, which guide lung morphogenesis and patterning in development and provide homeostatic barrier protection from microbes and toxins. The stability of lung alveoli, the luminal secretion of surfactants and mucus in the airways, and t...
Source: Current Topics in Developmental Biology - April 26, 2023 Category: Biology Authors: Andrew M Tilston-Lunel Xaralabos Varelas Source Type: research
Polarity in breast development and cancer
We describe cell lines, organoids, and in vivo models commonly used for studying apical-basal polarity in breast development and disease and discuss advantages and limitations of each. We also provide examples of how core polarity proteins regulate branching morphogenesis and lactation during development. We describe alterations to core polarity genes in breast cancer and their associations with patient outcomes. The impact of up- or down-regulation of key polarity proteins in breast cancer initiation, growth, invasion, metastasis, and therapeutic resistance are discussed. We also introduce studies demonstrating that polar...
Source: Current Topics in Developmental Biology - April 26, 2023 Category: Biology Authors: Mara K M Whitford Luke McCaffrey Source Type: research
Polarity in respiratory development, homeostasis and disease
Curr Top Dev Biol. 2023;154:285-315. doi: 10.1016/bs.ctdb.2023.02.004. Epub 2023 Mar 15.ABSTRACTThe respiratory system is composed of a multitude of cells that organize to form complex branched airways that end in alveoli, which respectively function to guide air flow and mediate gas exchange with the bloodstream. The organization of the respiratory sytem relies on distinct forms of cell polarity, which guide lung morphogenesis and patterning in development and provide homeostatic barrier protection from microbes and toxins. The stability of lung alveoli, the luminal secretion of surfactants and mucus in the airways, and t...
Source: Current Topics in Developmental Biology - April 26, 2023 Category: Biology Authors: Andrew M Tilston-Lunel Xaralabos Varelas Source Type: research
Polarity in breast development and cancer
We describe cell lines, organoids, and in vivo models commonly used for studying apical-basal polarity in breast development and disease and discuss advantages and limitations of each. We also provide examples of how core polarity proteins regulate branching morphogenesis and lactation during development. We describe alterations to core polarity genes in breast cancer and their associations with patient outcomes. The impact of up- or down-regulation of key polarity proteins in breast cancer initiation, growth, invasion, metastasis, and therapeutic resistance are discussed. We also introduce studies demonstrating that polar...
Source: Current Topics in Developmental Biology - April 26, 2023 Category: Biology Authors: Mara K M Whitford Luke McCaffrey Source Type: research
