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Specialty: Allergy & Immunology
Cancer: Epithelial Cancer
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Total 355 results found since Jan 2013.
Tanshinone I attenuates gastric precancerous lesions by inhibiting epithelial mesenchymal transition through the p38/STAT3 pathway
CONCLUSION: This study showed that Tan-I inhibited the progression of GPLs by reversing the EMT process and reducing inflammation by restraining the p38/STAT3 signaling pathway.PMID:37699302 | DOI:10.1016/j.intimp.2023.110902
Source: International Immunopharmacology - September 12, 2023 Category: Allergy & Immunology Authors: Dan Liang Shiyun Tang Lu Liu Maoyuan Zhao Xiao Ma Yanling Zhao Caifei Shen Qingsong Liu Jianyuan Tang Jinhao Zeng Nianzhi Chen Source Type: research
Peficitinib ameliorates 5-fluorouracil-induced intestinal damage by inhibiting aging, inflammatory factors and oxidative stress
In conclusion, peficitinib alleviates mucositis by alleviating aging, reducing inflammatory accumulation and oxidative stress and enhancing the antitumor activity of 5-FU.PMID:37572505 | DOI:10.1016/j.intimp.2023.110753
Source: International Immunopharmacology - August 12, 2023 Category: Allergy & Immunology Authors: Siyue He Jing Xia Huijie Jia Qianlong Dai Cui Chen Yue Zhou Xiao Bo Wang Source Type: research
N-(2-hydroxy phenyl) acetamide ameliorate inflammation and doxorubicin-induced nephrotoxicity in rats
The objectives of this study is to investigate the possible anti-inflammatory and nephroprotective effects of salicylic acid derivative, N-(2-hydroxy phenyl) acetamide (NA-2), in a rat model of DOX-induced nephrotoxicity. The in vitro anti-inflammatory potential of NA-2 was manifested by whole blood oxidative burst and nitric oxide (NO) assays with no toxicity on normal human fibroblast (BJ) cells, human embryonic kidney (HEK-293) cells, and normal monkey kidney epithelial (Vero) cells. The in vivo study included five groups: Normal control, DOX (6 mg/kg DOX-i.v.via tail vein), NA-2 treated control-i.p., NA-2/DOX treated-i...
Source: International Immunopharmacology - August 12, 2023 Category: Allergy & Immunology Authors: Sidrah Shams Loay Ibrahim Lubbad Shabana U Simjee Almas Jabeen Source Type: research
STAT3 inhibition enhances gemcitabine sensitivity in pancreatic cancer by suppressing EMT, immune escape and inducing oxidative stress damage
Int Immunopharmacol. 2023 Jul 27;123:110709. doi: 10.1016/j.intimp.2023.110709. Online ahead of print.ABSTRACTPancreatic cancer (PC) is a highly-malignant tumor of the digestive system with a very poor prognosis and high mortality. Chemotherapy and PD-1/PD-L1 immune checkpoint blockade are important treatment strategies for advanced PC. However, chemotherapy resistance and poor therapeutic effect of immune checkpoint inhibitors is are the main clinical problems to be solved urgently at present. The effects of combined application of gemcitabine and STAT3 inhibition on the proliferation, apoptosis, migration, and invasion o...
Source: International Immunopharmacology - July 29, 2023 Category: Allergy & Immunology Authors: Hangcheng Guo Zujian Hu Xuejia Yang Ziwei Yuan Yuanyuan Gao Jiawei Chen Lili Xie Chaoyue Chen Yangyang Guo Yongheng Bai Source Type: research
Phloretin suppresses intestinal inflammation and maintained epithelial tight junction integrity by modulating cytokines secretion in in vitro model of gut inflammation
In this study we have explored the anti-inflammatory potential of phloretin, in in vitro gut inflammation model, developed by co-culture of Caco2 (intestinal epithelial) cells and RAW264.7 macrophages (immune cells). Phloretin is a dihydrochalcone present in apple, pear and strawberries. An anti-inflammatory effect of phloretin in reducing LPS induced inflammation and maintenance of transepithelial electric resistance (TEER) in Caco2 cells was examined. Paracellular permeability assay was performed using Lucifer yellow dye to evaluate the effect of phloretin in inhibiting gut leakiness caused by inflammatory mediators secr...
Source: Cellular Immunology - July 28, 2023 Category: Allergy & Immunology Authors: Smita Kapoor Yogendra S Padwad Source Type: research
Epithelial TIPE1 Protein Guards against Colitis by Inhibiting TNF- α-Mediated Inflammation
In this study, we found that a member of the TNF-α-induced protein 8 (TNFAIP8 or TIPE) family called TIPE1 is indispensable for maintaining epithelial cell barrier integrity and homeostasis under inflammatory conditions. TIPE1-deficient mice, or chimeric mice that were deficient in TIPE1 in their nonhematopoietic cells, were more sensitive to dextran sulfate sodium-induced experimental colitis; however, TIPE1 deficiency had no impact on the development of inflammation-associated and sporadic colorectal cancers. Mechanistically, TIPE1 prevented experimental colitis through modulation of TNF-α-dependent inflammatory respon...
Source: Journal of Immunology - July 17, 2023 Category: Allergy & Immunology Authors: Yunwei Lou Shan Jiang Miaomiao Song Han Wang Meijuan Han Xueqin Tian Yuxin Zhao Jingtao Gao Yaru Song Shujun Ma Peiqing Zhao Qianqian Zheng Zhiyuan Niu Wen Zhang Tingmin Chang Youhai H Chen Hui Wang Source Type: research
ACSL4 promotes ferroptosis and M1 macrophage polarization to regulate the tumorigenesis of nasopharyngeal carcinoma
CONCLUSION: Our findings indicated that ACSL4 inhibited the pathogenesis of NPC, at least through crosstalk between ferroptosis and macrophages, providing potential direction for NPC therapy.PMID:37451020 | DOI:10.1016/j.intimp.2023.110629
Source: International Immunopharmacology - July 14, 2023 Category: Allergy & Immunology Authors: Pan Chen Dan Wang Tengfei Xiao Wangning Gu Hongmin Yang Minghua Yang Hui Wang Source Type: research
CD24 blockade as a novel strategy for cancer treatment
Int Immunopharmacol. 2023 Jun 26;121:110557. doi: 10.1016/j.intimp.2023.110557. Online ahead of print.ABSTRACTThe CD24 protein is a heat-stable protein with a small core that undergoes extensive glycosylation. It is expressed on the surface of various normal cells, including lymphocytes, epithelial cells, and inflammatory cells. CD24 exerts its function by binding to different ligands. Numerous studies have demonstrated the close association of CD24 with tumor occurrence and progression. CD24 not only facilitates tumor cell proliferation, metastasis, and immune evasion but also plays a role in tumor initiation, thus, servi...
Source: International Immunopharmacology - June 28, 2023 Category: Allergy & Immunology Authors: Yawen Wang Haoran Yu Mengyuan Yu Hui Liu Bing Zhang Yuanyuan Wang Simin Zhao Qingxin Xia Source Type: research
