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Curcumin induces mitophagy by promoting mitochondrial succinate dehydrogenase activity and sensitizes human papillary thyroid carcinoma BCPAP cells to radioiodine treatment
Toxicol In Vitro. 2023 Aug 25:105669. doi: 10.1016/j.tiv.2023.105669. Online ahead of print.ABSTRACTThyroid cancer is one of the most common endocrine malignancies. Differentiated thyroid cancer (DTC) treatment is based on the ability of thyroid follicular cells to accumulate radioactive iodide (RAI). DTC generally has a good prognosis. However, tumor dedifferentiation or defect in certain cell death mechanism occurs in a subset of DTC patients, leading to RAI resistance. Therefore, developing novel therapeutic approaches that enhance RAI sensitivity are still warranted. We found that curcumin, an active ingredient in turm...
Source: Toxicology in Vitro - August 27, 2023 Category: Toxicology Authors: Li Zhang Ling Qiu Shichen Xu Xian Cheng Jing Wu Yunping Wang Wenjing Gao Jiandong Bao Huixin Yu Source Type: research

MiRNAs: Emerging agents for therapeutic effects of polyphenols on ovarian cancer
Mini Rev Med Chem. 2023 Aug 16. doi: 10.2174/1389557523666230816090138. Online ahead of print.ABSTRACTIn terms of female reproductive tract cancers, ovarian cancer remains the principal reason for mortality globally and is notably difficult to identify in its early stages. This fact highlights the critical need to establish prevention strategies for patients with ovarian cancer, look for new robust diagnostic and prognostic markers, and identify potential targets of response to treatment. MicroRNAs (miRNAs) are one of the novel treatment targets in cancer treatment. Thus, understanding the part of miRNAs in the pathogenesi...
Source: Mini Reviews in Medicinal Chemistry - August 17, 2023 Category: Chemistry Authors: Bita Badehnoosh Nesa Rajabpoor Nikoo Reza Asemi Rana Shafabakhsh Zatollah Asemi Source Type: research

Synergistic Effects of New Curcumin Analog (PAC) and Cisplatin on Oral Cancer Therapy
In this study, we aimed to assess the potential complementary effects of PAC in combination with cisplatin for treating oral cancer. We conducted experiments using oral cancer cell lines (Ca9-22) treated with different concentrations of cisplatin (ranging from 0.1 μM to 1 μM), either alone or in conjunction with PAC (2.5 and 5 μM). Cell growth was measured using the MTT assay, while cell cytotoxicity was evaluated using an LDH assay. Propidium iodide and annexin V staining were employed to examine the impact on cell apoptosis. Flow cytometry was used to investigate the effects of the PAC/cisplatin combination on cancer ...
Source: Current Issues in Molecular Biology - June 27, 2023 Category: Molecular Biology Authors: Abdelhabib Semlali Sarra Beji Ikram Ajala Mohammed Al-Zharani Mahmoud Rouabhia Source Type: research

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