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LncRNA-LINC00472 suppresses the malignant progression of non-small cell lung cancer via modulation of the miRNA-1275/Homeobox A2 axis
CONCLUSIONS: The LINC00472 functioned as a competing endogenous RNA to modulate HOXA2 level by sponging miR-1275 in NSCLC. Simultaneously, the LINC00472/miR-1275/HOXA2 axis may be a possible therapeutic target and biomarker for NSCLC.PMID:37665081 | DOI:10.17219/acem/168431
Source: Clinical Lung Cancer - September 4, 2023 Category: Cancer & Oncology Authors: Meichen Jiang Xiangli Ye Dongliang Shi Qili Lin Feijian Huang Yong Li Source Type: research

Phenotypic and functional characterization of subpopulation of Imatinib resistant chronic myeloid leukemia cell line
CONCLUSION: Treating CML patients with tyrosine kinase inhibitors (TKIs) as well as targeting adhesion molecules deemed to be effective approaches in prevention of IMA resistance emergence which in turn may provide promising effects in the clinical management of CML patients.PMID:37421850 | DOI:10.1016/j.advms.2023.06.002
Source: Advances in Medical Sciences - July 8, 2023 Category: Biomedical Science Authors: Yalda Hekmatshoar Aynur Karadag Gurel Tulin Ozkan Yalda Rahbar Saadat Asli Koc Arzu Zeynep Karabay Sureyya Bozkurt Asuman Sunguroglu Source Type: research

Unusual presentation of breast adenoid cystic carcinoma resembling adenomyoepithelioma with multiple distinct foci
We describe an unusual case of multifocal breast adenoid cystic carcinoma (AdCC) with adenomyoepitheliomatous morphology. Most breast AdCCs are unifocal and only four cases of multifocal AdCC have been reported previously, however, to our best knowledge, multifocality in AdCC confirmed by molecular analysis has not been reported, so this report adds to the literature on this unique presentation. An 80-year-old woman presented with a left breast mass at 1 o'clock and non-mass enhancement lesion at 5 o'clock on imaging. Incisional biopsy at 1 o'clock showed AdCC based on histopathological features and MYB rearrangement by fl...
Source: Pathology, Research and Practice - July 1, 2023 Category: Pathology Authors: Hirofumi Matsumoto Hiroshi Harada Yuma Tsuruta Yuiko Yasutomi Norihiro Nakada Sakiko Kondo Ayako Koki Mikiko Unesoko Norie Abe Hisamitsu Zaha Puay Hoon Tan Source Type: research

MYC overexpression in inflammatory bowel disease-associated conventional dysplasia and association of subsequent low-grade dysplasia in follow-up biopsies
CONCLUSION: MYC IHC can complement p53 IHC as an adjunct biomarker for diagnosing IBD-associated conventional LGD and can be used for the prediction of subsequent LGD in the follow-up biopsies combined with endoscopic features.PMID:37379711 | DOI:10.1016/j.prp.2023.154642
Source: Pathology, Research and Practice - June 28, 2023 Category: Pathology Authors: Yuanxin Liang Yansheng Hao Yiqin Xiong Minghao Zhong Dhanpat Jain Source Type: research

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