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Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues. Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/ With the caveat that mouse models of Alzheimer's...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Highly-specific aptamer targeting SARS-CoV-2 S1 protein screened on an automatic integrated microfluidic system for COVID-19 diagnosis
Anal Chim Acta. 2023 Sep 15;1274:341531. doi: 10.1016/j.aca.2023.341531. Epub 2023 Jun 21.ABSTRACTVariants of the severe acute respiratory syndrome coronavirus (SARS-CoV-2) have evolved such that it may be challenging for diagnosis and clinical treatment of the pandemic coronavirus disease-19 (COVID-19). Compared with developed SARS-CoV-2 diagnostic tools recently, aptamers may exhibit some advantages, including high specificity/affinity, longer shelf life (vs. antibodies), and could be easily prepared. Herein an integrated microfluidic system was developed to automatically carry out one novel screening process based on th...
Source: Analytica Chimica Acta - July 16, 2023 Category: Chemistry Authors: Hung-Bin Wu Chih-Hung Wang Yi-Da Chung Yan-Shen Shan Ying-Jun Lin Huey-Pin Tsai Gwo-Bin Lee Source Type: research

Human Papillomavirus E1 Protein Regulates Gene Expression in Cells Involved in Immune Response
Appl Biochem Biotechnol. 2022 Nov 23. doi: 10.1007/s12010-022-04249-0. Online ahead of print.ABSTRACTHuman papillomavirus belongs to papovaviridae family papillomavirus A, a spherical deoxyribonucleic acid (DNA) virus, which can cause the proliferation of squamous epithelial cells of human skin or mucous membranes. With the rapid increase in the incidence of condyloma acuminatum among STDs and the increase in diseases caused by HPV infection, HPV infection has seriously endangered human health. In this paper, the in vitro detection of HPV E1 protein was realized using AgNCs-dsDNA. And through the test of this detection met...
Source: Applied Biochemistry and Biotechnology - November 23, 2022 Category: Biochemistry Authors: Zifeng Wang Shimin Guan Baoguo Cai Shaofeng Rong Qianqian Li Source Type: research

Induction of pulmonary HLA-G expression by SARS-CoV-2 infection
Cell Mol Life Sci. 2022 Nov 5;79(11):582. doi: 10.1007/s00018-022-04592-9.ABSTRACTThe non-classical human leukocyte antigen (HLA)-G exerts immune-suppressive properties modulating both NK and T cell responses. While it is physiologically expressed at the maternal-fetal interface and in immune-privileged organs, HLA-G expression is found in tumors and in virus-infected cells. So far, there exists little information about the role of HLA-G and its interplay with immune cells in biopsies, surgical specimen or autopsy tissues of lung, kidney and/or heart muscle from SARS-CoV-2-infected patients compared to control tissues. Het...
Source: Cancer Control - November 5, 2022 Category: Cancer & Oncology Authors: Barbara Seliger Simon Jasinski-Bergner Chiara Massa Anja Mueller Katharina Biehl Bo Yang Michael Bachmann Danny Jonigk Philip Eichhorn Arndt Hartmann Claudia Wickenhauser Marcus Bauer Source Type: research

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