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Role of steroid receptor-associated and regulated protein in tumor progression and progesterone receptor signaling in endometrial cancer
CONCLUSIONS: This study illustrates that SRARP exerts a tumor-suppressive effect by inhibiting the epithelial-mesenchymal transition via Wnt signaling in EC. In addition, SRARP positively modulates PR expression and interacts with PR to regulate PR downstream target genes.PMID:37144734 | DOI:10.1097/CM9.0000000000002537
Source: Chinese Medical Journal - May 5, 2023 Category: General Medicine Authors: Jie Liu Zhiqi Wang Jingyi Zhou Jiaqi Wang Xiangjun He Jianliu Wang Source Type: research

Estrogen Inhibits Epithelial Progesterone Receptor-dependent Progestin Therapy Efficacy in a Mouse Model of Cervical Cancer
Am J Pathol. 2021 Nov 10:S0002-9440(21)00469-7. doi: 10.1016/j.ajpath.2021.10.008. Online ahead of print.ABSTRACTWhile the uterine cervix responds to the female sex hormone change, the role of progesterone in cervical cancer is poorly understood. It has been shown that medroxyprogesterone acetate (MPA) regresses cervical cancer in the transgenic mouse model expressing human papillomavirus type 16 (HPV16) E6 and E7 oncogenes. As MPA interacts most strongly with progesterone receptor (PR), we reasoned that PR would contribute to MPA-induced regression of cervical cancer. We also hypothesized that estrogen influences the ther...
Source: The American Journal of Pathology - November 14, 2021 Category: Pathology Authors: Seunghan Baik Fabiola F Mehta Esra Unsal Yuri Park Sang-Hyuk Chung Source Type: research

Hormone replacement therapy after surgery for epithelial ovarian cancer.
CONCLUSIONS: Hormone replacement therapy may slightly improve overall survival in women who have undergone surgical treatment for EOC, but the certainty of the evidence is low. HRT may make little or no difference to quality of life, incidence of breast cancer, TIA, CVA and MI as the certainty of the evidence has been assessed as very low. There may be little or no effect of HRT use on progression-free survival. The evidence in this review is limited by imprecision and incompleteness of reported relevant outcomes and therefore the results should be interpreted with caution. Future well-designed RCTs are required as this is...
Source: Cochrane Database of Systematic Reviews - January 27, 2020 Category: General Medicine Authors: Saeaib N, Peeyananjarassri K, Liabsuetrakul T, Buhachat R, Myriokefalitaki E Tags: Cochrane Database Syst Rev Source Type: research

Abstract 37: Role and regulation of CYP24A1 in endometrial cancer
The cytochrome P450 enzyme, 24-hydroxylase, encoded by CYP24A1 is critical for the catabolism of 1,25(OH)2D3 (calcitriol). The unbalanced high levels of CYP24A1 seem to be a determinant of calcitriol resistance in tumors. We have previously shown that progesterone enhances calcitriol antitumor activity by upregulating vitamin D receptor expression and promoting apoptosis in endometrial cancer cells. In the present study, we evaluated CYP24A1 protein expression in normal and endometrial tumor tissues, assessed the effect of progesterone and calcitriol on CYP24A1 and its spliced variant expression in endometrial cancer cell ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Bokhari, A. A., Lee, L. R., Dewayne, R., Hamilton, C. A., Maxwell, G. L., Rodriguez, G. C., Syed, V. Tags: Molecular and Cellular Biology Source Type: research

The PRB-dependent FOXO1/IGFBP-1 axis is essential for progestin to inhibit endometrial epithelial growth
Abstract: Progestin inhibits the growth of normal and cancerous endometria via the progesterone receptor (PR), but the distinct functions and signalings of PR subtypes have not been fully understood. The aim of the present study was to dissect the key pathways of progestin to inhibit endometrial epithelial growth. Immortalized endometrial epithelial cells (EM-E6/E7/TERT) with stable PRA or PRB expression were established and used for the experiments. In vitro growth inhibition by progestin was mainly observed in EM-E6/E7/TERT cells with PRB rather than those with PRA. RT-PCR assay confirmed that FOXO1, a key gene for proge...
Source: Cancer Letters - May 13, 2013 Category: Cancer & Oncology Authors: Mitsuhiro Nakamura, Masahiro Takakura, Reina Fujii, Yoshiko Maida, Yukiko Bono, Yasunari Mizumoto, Xian Zhang, Tohru Kiyono, Satoru Kyo Tags: Research Articles Source Type: research