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Genome-wide Epigenetic Study of Chronic Rhinosinusitis Tissues Reveals Dysregulated Inflammatory, Immunologic and Remodeling Pathways
CONCLUSIONS: Differential patterns of methylation were identified between controls and CRS, CRSwNP, and CRSsNP. Epigenetic, environmentally-induced changes related to novel, inflammatory, immunologic, and remodeling pathways appear to affect epithelial integrity, cell proliferation, homeostasis, vascular permeability, and other yet uncharacterized pathways and genes.PMID:37584357 | DOI:10.1177/19458924231193526
Source: American Journal of Rhinology and Allergy - August 16, 2023 Category: ENT & OMF Authors: Tripti Brar Saurabh Baheti Michael J Marino Hirohito Kita Devyani Lal Source Type: research

The G-protein-coupled estrogen receptor, a gene co-expressed with ER α in breast tumors, is regulated by estrogen-ERα signalling in ERα positive breast cancer cells
In conclusion, GPER is positively associated with ERα in breast tumors, and induced by estrogen-ERα signalling axis. Estrogen-mediated induction of GPER makes the cells more responsive to GPER ligands. More in-depth studies are warranted to establish the significance of GPER-ERα co-expression, and their interplay in breast tumor development, progression, and treatment.PMID:37279863 | DOI:10.1016/j.gene.2023.147548
Source: Gene - June 6, 2023 Category: Genetics & Stem Cells Authors: Uttariya Pal Mohan C Manjegowda Neha Singh Snigdha Saikia Betty S Philip Deep Jyoti Kalita Avdhesh Kumar Rai Anupam Sarma Vandana Raphael Deepak Modi Amal Chandra Kataki Anil Mukund Limaye Source Type: research

G0S2 promotes antiestrogenic and pro-migratory responses in ER+ and ER- breast cancer cells
In this report, we dissect the role of G0S2 in ER+ versus ER- breast cancer. Overexpression of G0S2 in ER- cells increased cell proliferation, while G0S2 overexpression in ER+ cells decreased cell proliferation. Transcriptome analysis revealed that G0S2 mediated distinct but overlapping transcriptional responses in ER- and ER+ cells. G0S2 reduced genes associated with an epithelial phenotype, especially in ER- cells, including CDH1, ELF3, STEAP4 and TACSTD2, suggesting promotion of the epithelial-mesenchymal transition (EMT). G0S2 also repressed estrogen signaling and estrogen receptor target gene signatures, especially in...
Source: Translational Oncology - April 22, 2023 Category: Cancer & Oncology Authors: Andrea K Corbet Emmanuel Bikorimana Raya I Boyd Doha Shokry Kelly Kries Ayush Gupta Anneliese Paton Zhengyang Sun Zeeshan Fazal Sarah J Freemantle Erik R Nelson Michael J Spinella Ratnakar Singh Source Type: research

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