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Mortality risk after the first occurrence of osteoporotic vertebral compression fractures in the general population: A nationwide cohort study
This study aimed to evaluate mortality risk after the first occurrence of OVCF in the general population using a nationwide dataset from the Korean National Health Insurance System. We identified 291,203 newly diagnosed patients with OVCF and 873,609 patients without OVCF at a ratio of 1:3 matched by sex and age between 2010 and 2012. We investigated the latent characteristics of patients’ demographic information and chronic comorbidities that could affect mortality when diagnosed with OVCF. By comparing the cohort data, the hazar d ratio for subsequent mortality in patients with OVCF was calculated and adjusted based on...
Source: PLoS One - September 14, 2023 Category: Biomedical Science Authors: Hee Jung Son Source Type: research

A scoping review protocol on diagnostic strategies to detect occult malignancies in individuals with ischemic stroke
ConclusionWe anticipate that the findings of this scoping review will identify strategies used to detect occult cancer in individuals with ischemic stroke and summarize their clinical utility (if reported). Addressing this knowledge gap will help guide the development of future clinical trials on occult cancer screening patients with ischemic stroke.
Source: PLoS One - July 21, 2023 Category: Biomedical Science Authors: Jenneke Leentjens Source Type: research

Trends in the incidence and prevalence of dysphagia requiring medical attention among adults in South Korea, 2006 –2016: A nationwide population study
by SuYeon Kwon, Seungwoo Cha, Junsik Kim, Kyungdo Han, Nam-Jong Paik, Won-Seok Kim The prevalence of dysphagia is increasing, resulting in socioeconomic burden, but previous reports have only been based on a limited populations. Therefore, we aimed to investigate the nationwide incidence and prevalence of dysphagia requiring medical attention to provide adequate information for healthcare planning and resource allocation. In this nationwide retrospective cohort study, the data of adults aged ≥20 years recorded from 2006 to 2016 were sourced from the Korean National Health Insurance Service database. Medical claim codes ...
Source: PLoS One - June 28, 2023 Category: Biomedical Science Authors: SuYeon Kwon Source Type: research

Long non-coding RNA HOXA11-AS regulates ischemic neuronal death by targeting miR-337-3p/YBX1 signaling pathway: protective effect of dexmedetomidine
This study aimed to explore the possible link between Dex and HOXA11-AS in protecting neuronal cells from by ischemia/reperfusion-induced apoptosis. We used oxygen-glucose deprivation and reoxygenation (OGD/R) in mouse neuroblastoma Neuro-2a cells and middle cerebral artery occlusion (MACO) mouse model to test the link. We found that Dex significantly alleviated OGD/R-induced DNA fragmentation, cell viability and apoptosis, and rescued the decreased HOXA11-AS expression after ischemic damage in Neuro-2a cells. Gain-/loss-of-function studies revealed that HOXA11-AS promoted proliferation, inhibited apoptosis in Neuro-2a cel...
Source: Aging - April 14, 2023 Category: Biomedical Science Authors: Fei Yan Pinxiao Wang Xiaojian Yang Fuli Wang Source Type: research

Neuroimaging findings and neurological manifestations in hospitalized COVID-19 patients: Impact of cancer and ventilatory support status
This study suggests COVID-19 is associated with neurological manifestations that may be visible with brain imaging techniques such as MRI. In our COVID-19 cohort, there was no association between cancer status and neuroimaging findings. Future studies might include more prospectively enrolled systematically characterized patients, allowing for more rigorous statistical analysis.
Source: PLoS One - March 24, 2023 Category: Biomedical Science Authors: Lily McCarthy Source Type: research

Causes of death of patients with non-valvular atrial fibrillation in Asians
ConclusionDeath due to ischemic stroke was responsible for only 4.7% of all deaths in Asian AF patients. Non-CV death, such as infection/sepsis or malignancy, was more far more prevalent than CV death in Asian AF patients. An improved integrated care approach is needed to reduce the prevalence of non-CV death in Asian AF patients.
Source: PLoS One - March 1, 2023 Category: Biomedical Science Authors: Rungroj Krittayaphong Source Type: research

The Association between Exposure to Second-Hand Smoke and Disease in the Chinese Population: A Systematic Review and Meta-Analysis
CONCLUSION: The effect of SHS exposure in China was similar to that in Western countries, but its definition and characterization require further clarification. Studies on the association between SHS exposure and certain diseases with high incidence rates are insufficient.PMID:36650679 | DOI:10.3967/bes2023.003
Source: Biomedical and Environmental Sciences : BES - January 18, 2023 Category: Biomedical Science Authors: Yu Tong Wang Kui Ru Hu Jian Zhao Fei Ling Ai Yu Lin Shi Xue Wei Wang Wen Yi Yang Jing Xin Wang Li Mei Ai Xia Wan Source Type: research

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