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Specialty: Drugs & Pharmacology
Cancer: Cancer
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Total 1000 results found since Jan 2013.
Lysosomal-mediated drug release and activation for cancer therapy and immunotherapy
Adv Drug Deliv Rev. 2022 Nov 23:114624. doi: 10.1016/j.addr.2022.114624. Online ahead of print.ABSTRACTThe development of carrier systems that are able to transport and release therapeutics to target cells is an emergent strategy to treat cancer; however, they following endocytosis are usually trapped in the endo/lysosomal compartments. The efficacy of drug conjugates and nanotherapeutics relies critically on their intracellular drug release ability, for which advanced systems responding to the unique lysosomal environment such as acidic pH and abundant enzymes (e.g. cathepsin B, sulfatase and β-glucuronidase) or equipped...
Source: Advanced Drug Delivery Reviews - November 26, 2022 Category: Drugs & Pharmacology Authors: Yinping Sun Yongjie Sha Guanhong Cui Fenghua Meng Zhiyuan Zhong Source Type: research
ASAP Recent Advancements in the Design of Nanodelivery Systems of siRNA for Cancer Therapy
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.2c00811
Source: Molecular Pharmaceutics - November 21, 2022 Category: Drugs & Pharmacology Authors: Dokkari Nagalaxmi Yadav, Mohammad Sadik Ali, Ajinkya Madhukar Thanekar, Sunil Venkanna Pogu, and Aravind Kumar Rengan Source Type: research
Retraction Note: Codelivery of HIF-1 α siRNA and Dinaciclib by Carboxylated Graphene Oxide-Trimethyl Chitosan-Hyaluronate Nanoparticles Significantly Suppresses Cancer Cell Progression
Source: Pharmaceutical Research - November 11, 2022 Category: Drugs & Pharmacology Source Type: research
Adenosine diphosphate-ribosylation factor-like 15 can regulate glycolysis and lipogenesis related genes in colon cancer
This study was designed to investigate the potential key genes of ADP-ribosylation factor-like 15 (ARL15) regulating glycolysis and lipogenesis in colon cancer. Hematoxylin-eosin (HE) staining and immunohistochemistry were used to observe the expression of ARL15 in 10 normal colon tissues and 10 colon cancer tissues. Immunofluorescence staining was used to observe the expression position of ARL15 in normal human colorectal mucosa cells (FHC) and colon cancer cells (HCT116 and SW620) with a confocal microscope. The ARL15 plasmid and small interfering RNA (siRNA) were constructed. After transfection, the expression levels of...
Source: Journal of Physiology and Pharmacology - October 27, 2022 Category: Drugs & Pharmacology Authors: F Du H-J Zhang W Shao Y-Y Tu K-J Yang L-S Piao Source Type: research
