Filtered By:
Specialty: Drugs & Pharmacology
Cancer: Cancer
This page shows you your search results in order of date. This is page number 12.
Order by Relevance | Date
Total 1000 results found since Jan 2013.
The effect of neuropilin-1 silencing on the transforming growth factor- β1-mediated epithelial-mesenchymal transition of colon cancer SW480 cells and its effect on the proliferation and migration of colon cancer cells
In conclusion: silencing, NRP-1 in colon cancer SW480 cells can partially reverse TGF-β1-mediated EMT, reduce the proliferation activity of colon cancer cells, and slow their migration ability. Therefore, NRP-1 may become a new target for the treatment of colon cancer.PMID:36193963 | DOI:10.26402/jpp.2022.2.07
Source: Journal of Physiology and Pharmacology - October 4, 2022 Category: Drugs & Pharmacology Authors: B Zhu Q-Q Zhan Q-Y Liu X Yang Y-H Ge G-Y Ding S Guo W-G Xu Source Type: research
Baicalin improved hepatic injury of NASH by regulating NRF2/HO-1/NRLP3 pathway
This study indicates that baicalin is able to attenuate hepatic cell pyroptosis in vivo and in vitro in the case of NASH by regulating the NRF2/HO-1/NRLP3 pathway.PMID:36184988 | DOI:10.1016/j.ejphar.2022.175270
Source: European Journal of Pharmacology - October 3, 2022 Category: Drugs & Pharmacology Authors: Huilian Shi Fei Qiao Weiting Lu Kaiyue Huang Yuanyuan Wen Lifang Ye Yuanyuan Chen Source Type: research
Inorganic nanoparticle-based advanced cancer therapies: promising combination strategies
Drug Discov Today. 2022 Sep 28:103386. doi: 10.1016/j.drudis.2022.103386. Online ahead of print.ABSTRACTInorganic nanoparticles for drug delivery in cancer treatment offer many potential advantages because they can maximize therapeutic effect through targeting ligands while minimizing off-target side-effects through drug adsorption and infiltration. Although inorganic nanoparticles were introduced as drug carriers, they have emerged as having the capacity for combined therapeutic capabilities, including anticancer effects through cytotoxicity, suppression of oncogenes and cancer cell signaling pathway inhibition. The most ...
Source: Drug Discovery Today - October 1, 2022 Category: Drugs & Pharmacology Authors: Maria John Newton Amaldoss Jia-Lin Yang Pramod Koshy Ashwin Unnikrishnan Charles C Sorrell Source Type: research
Directing the Way —Receptor and Chemical Targeting Strategies for Nucleic Acid Delivery
AbstractNucleic acid therapeutics have shown great potential for the treatment of numerous diseases, such as genetic disorders, cancer and infections. Moreover, they have been successfully used as vaccines during the COVID-19 pandemic. In order to unfold full therapeutical potential, these nano agents have to overcome several barriers. Therefore, directed transport to specific tissues and cell types remains a central challenge to receive carrier systems with enhanced efficiency and desired biodistribution profiles. Active targeting strategies include receptor-targeting, mediating cellular uptake based on ligand-receptor in...
Source: Pharmaceutical Research - September 15, 2022 Category: Drugs & Pharmacology Source Type: research
Advancement of cell-penetrating peptides in combating triple-negative breast cancer
Drug Discov Today. 2022 Sep 10:103353. doi: 10.1016/j.drudis.2022.103353. Online ahead of print.ABSTRACTExtensive research efforts have been made and are still ongoing in the search for an ideal anti-cancer therapy. Almost all chemotherapeutics require a carrier or vehicle, a drug delivery system that can transport the drug specifically to the targeted cancer cells, sparing normal cells. Cell-penetrating peptides (CPPs) provide an effective and efficient pathway for the intra-cellular transportation of various bioactive molecules in several biomedical therapies. They are now well-recognized as facilitators of intracellular...
Source: Drug Discovery Today - September 13, 2022 Category: Drugs & Pharmacology Authors: Mahak Fatima Mohammed A S Abourehab Geeta Aggarwal Gaurav K Jain Amirhossein Sahebkar Prashant Kesharwani Source Type: research
Raltitrexed regulates proliferation and apoptosis of HGC-27 cells by upregulating RSK4
CONCLUSION: Our study shows that RSK4 is a key target of raltitrexed in the regulation of gastric cancer cell proliferation, cell cycle progression, and apoptosis.PMID:36031631 | DOI:10.1186/s40360-022-00605-2
Source: BMC Pharmacology and Toxicology - August 28, 2022 Category: Drugs & Pharmacology Authors: Cong Hu Xinhua Chen Xu Lin Jun Dai Jiang Yu Source Type: research
