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What Are Some Indications for Using Dexamethasone?
Discussion Corticosteroids are a group of drugs which can be naturally or synthetically produced. Naturally occurring substances are produced in the adrenal gland, and are protein-bound (primarily corticosteroid-binding globulin and albumin). In the target tissues, they may need to be converted to an active substance. They are then reduced, oxidized, hydroxylated or conjugated as measures to inactivate them. Synthetic steroids have less protein binding and depending on their structure are more or less resistant to inactivation. Prednisone is the glucocorticoid most often used for treatment, especially as it has a short hal...
Source: PediatricEducation.org - June 7, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Nutritional Heterogeneity Among Aspergillus fumigatus Strains Has Consequences for Virulence in a Strain- and Host-Dependent Manner
We examined the relationship between the metabolic processes of carbon catabolite repression (CCR), nitrogen catabolite repression (NCR) and virulence in a variety of A. fumigatus clinical isolates. A considerable amount of heterogeneity with respect to the degree of CCR and NCR was observed and a positive correlation between NCR and virulence in a neutropenic mouse model of pulmonary aspergillosis (PA) was found. Isolate Afs35 was selected for further analysis and compared to the reference strain A1163, with both strains presenting the same degree of virulence in a neutropenic mouse model of PA. Afs35 metabolome analysis ...
Source: Frontiers in Microbiology - April 23, 2019 Category: Microbiology Source Type: research

Spring health cheat sheet
As the spring weather approaches, many common winter infections recede. However, warmer temperatures can introduce a new set of health challenges. As trees and flowers bloom and grass grows, susceptible children will start to display symptoms of seasonal allergies, triggering flares of asthma and eczema. And, As children spend more time outdoors, parents also need to watch for exposure to ticks, poison ivy and excess sun. Here are a few tips to keeping your child healthy this spring. Seasonal allergies: What can you do? During allergy season: have your child bathe after spending time outdoors to remove allergens fro...
Source: Thrive, Children's Hospital Boston - April 7, 2017 Category: Pediatrics Authors: Carolyn Sax Tags: Health & Wellness Parenting allergies asthma Carolyn Sax conjunctivitis lyme disease sunburn Source Type: news