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Surgical Outcomes of Gastrectomy in Hemodialysis Patients with Gastric Cancer
Am Surg. 2023 May 3:31348231173970. doi: 10.1177/00031348231173970. Online ahead of print.NO ABSTRACTPMID:37132264 | DOI:10.1177/00031348231173970
Source: The American Surgeon - May 3, 2023 Category: Surgery Authors: Toshiaki Yoshimoto Kozo Yoshikawa Toshihiro Nakao Takuya Tokunaga Masaaki Nishi Chie Takasu Hideya Kashihara Yuma Wada Takayuki Noma Mitsuo Shimada Source Type: research

Effect of Severe Renal Dysfunction on the Plasma Levels of DNA-Reactive Platinum after Oxaliplatin Administration
This study aimed to quantify DNA-reactive fPt in plasma and to evaluate the impact of severe renal dysfunction on its pharmacokinetics. The pharmacokinetics of oxaliplatin was assessed in rats with bilateral nephrectomy (BNx) and in a hemodialysis patient who received mFOLFOX7 therapy for advanced metastatic gastric cancer. The platinum concentrations were determined using inductively coupled plasma-mass spectrometry. The amount of DNA-reactive fPt in the plasma was evaluated by the reaction between plasma and calf thymus DNA. Compared to the sham group in rats, the BNx group had significantly higher plasma total fPt conce...
Source: Biological and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Shunsaku Nakagawa Aimi Shimazaki Taro Funakoshi Atsushi Yonezawa Shigeki Kataoka Takahiro Horimatsu Daiki Hira Kotaro Itohara Satoshi Imai Takayuki Nakagawa Takeshi Matsubara Motoko Yanagita Manabu Muto Kazuo Matsubara Tomohiro Terada Source Type: research

Fight Aging! Newsletter, October 4th 2021
In conclusion, premature thymic involution and chronic inflammation greatly contribute to increased morbidity and mortality in CKD patients. Mechanisms are likely to be multiple and interlinked. Even when the quest to fountain of youth is a pipe dream, there are many scientific opportunities to prevent or to, at least in part, reverse CKD-related immune senescence. Further studies should precisely define most important pathways driving premature immune ageing in CKD patients and best therapeutic options to control them. Extending Life Without Extending Health: Vast Effort Directed to the Wrong Goals https://www...
Source: Fight Aging! - October 3, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs