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Loss-of-Function in SMAD4 Might Not Be Critical for Human Natural Killer Cell Responsiveness to TGF- β
This study was carried out in accordance with approval of the Melbourne Health and Walter and Eliza Hall Institute of Medical Research's Human Research Ethics Committee (approval number: 2013.081). All subjects gave written informed consent for participation and publication. Results and Discussion TGF-β signaling in NK cells is associated with: phosphorylation in SMAD2 and 3, inhibition of IL-15-induced metabolism/proliferation, simultaneous downregulation of CD44, CD49e, and Eomes, and upregulation of CD16 and CD49a expression (7, 10). SMAD family member 4 (SMAD4) belongs to the SMAD family of transcript...
Source: Frontiers in Immunology - April 30, 2019 Category: Allergy & Immunology Source Type: research

Two weeks to bowel cancer?
There’s no doubt antibiotics have saved a lot of lives. But because they’ve been overprescribed for so many years we’ve ended up with a slew of health problems. For one thing, overuse of antibiotics wreaks havoc on your microbiome… That’s your body’s ecosystem. Your microbiome has 100 trillion or so bacteria, viruses and fungi. It affects just about every organ and body system. Some of these gut bugs cause disease and infection. But other good bacteria are called “probiotics.” They boost your immune system. They help you digest your food and turn it into vitamins. But in ...
Source: Al Sears, MD Natural Remedies - October 5, 2017 Category: Complementary Medicine Authors: Randall Hall Tags: Cancer Health Men's Health Source Type: news