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Development of transgenic models susceptible and resistant to SARS-CoV-2 infection in FVB background mice
In this study, we compared the susceptibility and resistance to SARS-CoV-2 infection between two strains of transgenic mice, which were generated in FVB background mice. K18-hACE2 mice exhibited sever e weight loss with definitive lethality, but CAG-hACE2 mice survived; and differences were observed in the lung, spleen, cerebrum, cerebellum, and small intestine. A higher viral titer was detected in the lungs, cerebrums, and cerebellums of K18-hACE2 mice than in the lungs of CAG-hACE2 mice. Severe pneumonia was observed in histopathological findings in K18-hACE2, and mild pneumonia was observed in CAG-hACE2. Atrophy of the ...
Source: PLoS One - July 26, 2022 Category: Biomedical Science Authors: Sun-Min Seo Source Type: research

Persistent Symptoms After Acute COVID-19 Infection in Omicron Era
CONCLUSION: The persistent symptoms of post COVID-19 condition involve multi-organ and continue for four weeks or greater. Therefore, long-term observation and multidisciplinary interventions are essential for patients with post COVID-19 conditions.PMID:35818704 | DOI:10.3346/jkms.2022.37.e213
Source: Journal of Korean Medical Science - July 12, 2022 Category: Biomedical Science Authors: Young Hee Jung Eun-Hye Ha Kang Won Choe Seungbok Lee Dong Ho Jo Wang Jun Lee Source Type: research

Subacute Thyroiditis After Receiving the mRNA COVID-19 Vaccine (Moderna): The First Case Report and Literature Review in Korea
We report this case to raise awareness of the occurrence of SAT after COVID-19 vaccination. As the risk of COVID-19 outweighs the minor risks of the vaccine, managing the side effects of the first vaccine dose is crucial to complete COVID-19 vaccination.PMID:35166076 | DOI:10.3346/jkms.2022.37.e39
Source: Journal of Korean Medical Science - February 15, 2022 Category: Biomedical Science Authors: Min Jhon Sun-Ho Lee Tae-Hoon Oh Ho-Cheol Kang Source Type: research

Research Articles A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters
Multiple safe and effective vaccines that elicit immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are necessary to respond to the ongoing coronavirus disease 2019 (COVID-19) pandemic. Here, we developed a protein subunit vaccine composed of spike ectodomain protein (StriFK) plus a nitrogen bisphosphonate–modified zinc-aluminum hybrid adjuvant (FH002C). StriFK-FH002C generated substantially higher neutralizing antibody titers in mice, hamsters, and cynomolgus monkeys than those observed in plasma isolated from COVID-19 convalescent individuals. StriFK-FH002C also induced both TH1- ...
Source: Science Translational Medicine - August 11, 2021 Category: Biomedical Science Authors: Wu, Y., Huang, X., Yuan, L., Wang, S., Zhang, Y., Xiong, H., Chen, R., Ma, J., Qi, R., Nie, M., Xu, J., Zhang, Z., Chen, L., Wei, M., Zhou, M., Cai, M., Shi, Y., Zhang, L., Yu, H., Hong, J., Wang, Z., Hong, Y., Yue, M., Li, Z., Chen, D., Zheng, Q., Li, S. Tags: Research Articles Source Type: research

Structure-based phylogeny identifies avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice
Drugs targeting host proteins can act prophylactically to reduce viral burden early in disease and limit morbidity, even with antivirals and vaccination. Transmembrane serine protease 2 (TMPRSS2) is a human protease required for SARS coronavirus 2 (SARS-CoV-2) viral entry and may represent such a target. We hypothesized that drugs selected from proteins related by their tertiary structure, rather than their primary structure, were likely to interact with TMPRSS2. We created a structure-based phylogenetic computational tool named 3DPhyloFold to systematically identify structurally similar serine proteases with known therape...
Source: Journal of Clinical Investigation - May 18, 2021 Category: Biomedical Science Authors: Young Joo Sun, Gabriel Velez, Dylan E. Parsons, Kun Li, Miguel E. Ortiz, Shaunik Sharma, Paul B. McCray Jr., Alexander G. Bassuk, Vinit B. Mahajan Source Type: research