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EPH43 Potential Association of Remdesivir and Hyperkalemia: A Disproportionality Analysis in USFDA Adverse Event Reporting System Database
Signal detection is one of the most advanced and promising techniques in the world of pharmacovigilance. Remdesivir is approved for emergency use by the US Food and Drug Administration (FDA) for patients with coronavirus disease 2019 (COVID-19). Its benefit- risk ratio is still being explored because data in the field are rather scant. On the other hand hyperkalemia is a potentially life-threatening electrolyte disorder. Severe hyperkalemia can occur suddenly and can cause life-threatening heart rhythm changes (arrhythmia) that cause a heart attack.
Source: Value in Health - June 1, 2023 Category: International Medicine & Public Health Authors: A. Das, M. Vajapu Source Type: research

News at a glance: New U.S. coronavirus research, lab gear ’s carbon cost, and a repurposed accelerator
MATERIALS SCIENCE Storied accelerator to test chips The world’s first superconducting cyclotron will receive a new lease on life testing next-generation microchips, Michigan State University’s Facility for Rare Isotope Beams (FRIB) announced last week. From 1982 to 2020, the K-500 cyclotron produced beams of atomic nuclei ranging from hydrogen to uranium for experiments in nuclear physics, relying on superconducting magnets to confine the particles. Last year, the cyclotron was replaced by FRIB’s new, more powerful, $730 million linear accelerator. Typically, old particle accelerators are demolished or...
Source: Science of Aging Knowledge Environment - April 13, 2023 Category: Geriatrics Source Type: research

MRI for all: Cheap portable scanners aim to revolutionize medical imaging
.news-article__hero--featured .parallax__element{ object-position: 47% 50%; -o-object-position: 47% 50%; } The patient, a man in his 70s with a shock of silver hair, lies in the neuro intensive care unit (neuro ICU) at Yale New Haven Hospital. Looking at him, you’d never know that a few days earlier a tumor was removed from his pituitary gland. The operation didn’t leave a mark because, as is standard, surgeons reached the tumor through his nose. He chats cheerfully with a pair of research associates who have come to check his progress with a new and potentially revolutionary device they are testing. The cylind...
Source: Science of Aging Knowledge Environment - February 23, 2023 Category: Geriatrics Source Type: research

News at a glance: Declining childhood vaccinations, rising ‘superbug’ infections, and a disputed Brazilian fossil
GLOBAL HEALTH Pandemic contributes to big drop in childhood vaccinations In what UNICEF Executive Director Catherine Russell called a “red alert,” childhood vaccination rates in many countries worldwide have dropped to the lowest level since 2008, in part because of the COVID-19 pandemic. UNICEF and the World Health Organization together track inoculations against diphtheria, pertussis, and tetanus—which are administered as one vaccine—as a marker for vaccination coverage overall. In 2021, only 81% of children worldwide received the recommended three doses of the combined vaccine, down from 86% in 20...
Source: Science of Aging Knowledge Environment - July 21, 2022 Category: Geriatrics Source Type: research

Bad news for Paxlovid? Coronavirus can find multiple ways to evade COVID-19 drug
Prescriptions for Pfizer’s blockbuster drug Paxlovid have skyrocketed in recent weeks. That’s good news for many COVID-19 patients, as the pill has been proven to reduce severe disease from SARS-CoV-2 infections. But a bevy of new lab studies shows the coronavirus can mutate in ways that make it less susceptible to the drug, by far the most widely used of the two oral antiviral drugs authorized to treat COVID-19 in the United States. Researchers have found some of those mutations in variants already circulating in infected people, raising fresh concerns that physicians could soon lose one of their best therapies for fi...
Source: ScienceNOW - June 29, 2022 Category: Science Source Type: news

Juul Is Paying $40 Million to Rebuild Its Reputation. Will It Work?
Juul Labs reached a $40 million settlement with North Carolina Attorney General Josh Stein this week, agreeing to limit its sales and marketing practices to quell underage use of its potent e-cigarettes. The settlement is also part of an “ongoing effort to reset our company and its relationship with our stakeholders” and “earn trust through action,” as a Juul spokesperson put it in a statement. In other words: Juul is trying to shed its reputation as the company that fueled a youth vaping epidemic, and it’s willing to pay $40 million to do it. [time-brightcove not-tgx=”true”] But ...
Source: TIME: Health - June 29, 2021 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Source Type: news

Vir, GSK win emergency use OK for Covid-fighting antibody
Little more than a year after Vir Biotechnology Inc. decided to scan its antibody library for potential foes of the coronavirus responsible for the Covid-19 pandemic, the San Francisco company and partner GlaxoSmithKline plc won a Food and Drug Administration emergency use authorization for their drug to treat people who test positive and are at high risk of progressing to severe sickness. The drug, called sotrovimab, walks a fine Covid treatment line: The monoclonal antibody has not shown benefit…
Source: bizjournals.com Health Care:Biotechnology headlines - May 26, 2021 Category: Biotechnology Authors: Ron Leuty Source Type: news

Remdesivir and acute renal failure: a potential safety signal from disproportionality analysis of the WHO safety database.
Abstract Remdesivir is approved for emergency use by the Food and Drug Administration (FDA) and authorized conditionally by the European Medicines Agency (EMA) for patients with Coronavirus disease 2019 (COVID-19). Its benefit-risk ratio is still being explored since data in the field are rather scant. A decrease of the creatinine clearance associated with remdesivir has been inconstantly reported in clinical trials with unclear relevance. Despite these uncertainties, we searched for a potential signal of acute renal failure (ARF) in pharmacovigilance postmarketing data. An analysis of the international pharmacovi...
Source: Clinical Pharmacology and Therapeutics - December 19, 2020 Category: Drugs & Pharmacology Authors: Gérard A, Laurain A, Fresse A, Parassol N, Muzzone M, Rocher F, Esnault VLM, Drici MD Tags: Clin Pharmacol Ther Source Type: research

United Imaging gets FDA clearance for uMR Omega
United Imaging has garnered U.S. Food and Drug Administration (FDA) 510(k)...Read more on AuntMinnie.comRelated Reading: United Imaging reaches installation milestone United Imaging signs another portable CT collaboration United Imaging donates scanning rooms to Chinese clinics United Imaging aids fight against coronavirus United Imaging launches mobile PET/CT unit at RSNA 2019
Source: AuntMinnie.com Headlines - May 26, 2020 Category: Radiology Source Type: news

A.C.L.U. Warns Against Fever-Screening Tools for Coronavirus
A report by the civil liberties group contends that reliance on thermal cameras and temperature-sensing guns to resume work at factories and offices and to encourage travel is flawed and intrusive.
Source: NYT Health - May 19, 2020 Category: Consumer Health News Authors: Natasha Singer Tags: Coronavirus (2019-nCoV) Coronavirus Reopenings Tests (Medical) American Civil Liberties Union Food and Drug Administration Centers for Disease Control and Prevention thermal camera temperature scan public health Workplace Environment L Source Type: news

Can Artificial Intelligence effectively and ethically detect COVID-19?
Is Artificial Intelligence (AI) a viable solution to the COVID-19 testing crisis? This has been a major question buzzing in the minds of healthcare leaders as they scramble to come up with solutions to the short-supply of the conventional tests. Some researchers believe that it ’s possible to develop a specialized method to detect specific markers of the virus via AI. However, COVID-19-detecting algorithms are based on data from only dozens or hundreds of patients, whereas a fully effective and functional algorithm requires thousands of patient scans. Recently written algorithms were developed using scans of infected C...
Source: radRounds - April 19, 2020 Category: Radiology Authors: Julie Morse Source Type: blogs

An At-Home Coronavirus Test May Be On the Way in the U.S.
As cases of COVID-19 continue to climb in the U.S., there’s a new urgency to make sure there are as many tests as possible to diagnose people who have symptoms that might indicate an infection. Knowing if people are positive is important for guiding their next steps: self-isolation, avoiding contact with others, and, if their symptoms get worse, seeking medical care. To date, access to tests has been spotty at best across the country, and while more kits are now available than even a week ago, most are gene-based assays that take several days for commercial labs to process and produce results. That may change in abo...
Source: TIME: Health - March 25, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news