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Viruses, Vol. 12, Pages 1325: Target-Centered Drug Repurposing Predictions of Human Angiotensin-Converting Enzyme 2 (ACE2) and Transmembrane Protease Serine Subtype 2 (TMPRSS2) Interacting Approved Drugs for Coronavirus Disease 2019 (COVID-19) Treatment through a Drug-Target Interaction Deep Learning Model
In this study, we used MT-DTI to predict FDA approved drugs that may have strong affinities for the angiotensin-converting enzyme 2 (ACE2) receptor and the transmembrane protease serine 2 (TMPRSS2) which are essential for viral entry to the host cell. Of the 460 drugs with Kd of less than 100 nM for the ACE2 receptor, 17 drugs overlapped with drugs that inhibit the interaction of ACE2 and SARS-CoV-2 spike reported in the NCATS OpenData portal. Among them, enalaprilat, an ACE inhibitor, showed a Kd value of 1.5 nM against the ACE2. Furthermore, three of the top 30 drugs with strong affinity prediction for the TMPRSS2 are an...
Source: Viruses - November 18, 2020 Category: Virology Authors: Yoonjung Choi Bonggun Shin Keunsoo Kang Sungsoo Park Bo Ram Beck Tags: Article Source Type: research
Child COVID Cases Have Increased 28% Over The Last Two Weeks, American Academy Of Pediatrics Says
(CNN) — As officials continue to warn about traveling over the holidays amid the fall surge, health experts are also investigating the virus’ impact on children.
There were more than 144,000 new cases of Covid-19 reported among children last week, the American Academy of Pediatrics (AAP) said Monday.
Over the last two weeks, there has been a 28% increase in child Covid-19 cases and children now account for more than 11% of all confirmed coronavirus cases in the US, according to the AAP.
About 144,145 new cases among children 17 and under were reported from November 12 to 19, AAP said.
As of Monday, the US has r...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 24, 2020 Category: Consumer Health News Authors: CBS Boston Tags: Boston News Covid-19 Boston, MA Seen On WBZ-TV Syndicated CBSN Boston Syndicated Local Coronavirus Source Type: news
COVID Vaccine Rollout Could Be ‘ Most Complex Immunization Effort ’ In History
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - December 2, 2020 Category: Consumer Health News Authors: CBS Boston Tags: Boston News Covid-19 Boston, MA Health Healthcare Status Healthwatch Syndicated CBSN Boston Syndicated Local Coronavirus Coronavirus Vaccine Dr. Ashish Jha Source Type: news
What Will The COVID-19 Vaccine Feel Like?
(CNN) — As the United States inches closer to authorizing a COVID-19 vaccine, many people may now let themselves start wondering what it will feel like to get it.
Is it going to be like the flu vaccine? Will it be more painful? And what about side-effects?
The two front-runners for getting an emergency use authorization from the US Food and Drug Administration — Pfizer/BioNTech and Moderna — use new mRNA technology. No U.S.-licensed vaccine has ever used it, although researchers have been studying it for decades against infections like flu, rabies and Zika, and even for some types of cancer.
The way these...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - December 3, 2020 Category: Consumer Health News Authors: CBS Boston Tags: Covid-19 Boston, MA Healthcare Status News Coronavirus Moderna Therapeutics Pfizer Source Type: news
COVID-19 Vaccination Cards To Be Simplest Way To Keep Track Of Shots
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - December 3, 2020 Category: Consumer Health News Authors: CBS Boston Tags: Boston News Covid-19 Boston, MA Health Healthcare Status Healthwatch Syndicated CBSN Boston Coronavirus Coronavirus Vaccine Source Type: news
FDA authorizes COVID booster shot for healthy kids ages 5 to 11
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - May 17, 2022 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News COVID-19 Covid-19 Boston, MA Health Healthwatch Syndicated CBSN Boston Coronavirus Source Type: news
Bad news for Paxlovid? Coronavirus can find multiple ways to evade COVID-19 drug
Prescriptions for Pfizer’s blockbuster drug Paxlovid have skyrocketed in recent weeks. That’s good news for many COVID-19 patients, as the pill has been proven to reduce severe disease from SARS-CoV-2 infections. But a bevy of new lab studies shows the coronavirus can mutate in ways that make it less susceptible to the drug, by far the most widely used of the two oral antiviral drugs authorized to treat COVID-19 in the United States. Researchers have found some of those mutations in variants already circulating in infected people, raising fresh concerns that physicians could soon lose one of their best therapies for fi...
Source: ScienceNOW - June 29, 2022 Category: Science Source Type: news
A Review of Extracorporeal Blood Purification Techniques for the Treatment of Critically Ill Coronavirus Disease 2019 Patients
In late 2019, a novel betacoronavirus, later termed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was discovered in patients with an unknown respiratory illness in Wuhan, China. SARS-CoV-2 and the disease caused by the novel coronavirus, coronavirus disease 2019 (COVID-19), spread rapidly and resulted in the World Health Organization declaring a pandemic in March 2020. In a minority of patients infected with SARS-CoV-2, severe illness develops characterized by a dysregulated immune response, acute respiratory distress syndrome, and multisystem organ failure. Despite the development of antiviral and multiple...
Source: ASAIO Journal - October 1, 2022 Category: Medical Devices Tags: Review Source Type: research
U.S. Health Officials Seek Emergency Approval to Use Diagnostic Test for New Coronavirus U.S. Health Officials Seek Emergency Approval to Use Diagnostic Test for New Coronavirus
The U.S. Centers for Disease Control and Prevention said on Thursday it is seeking special emergency authorization from the Food and Drug Administration to allow U.S. states to use a CDC-developed diagnostic test to detect the new coronavirus from China.Reuters Health Information
Source: Medscape Medical News Headlines - January 23, 2020 Category: Consumer Health News Tags: Medscape Today News Source Type: news
FDA takes action to counter novel coronavirus
The U.S. Food and Drug Administration (FDA) outlined steps it plans to take...Read more on AuntMinnie.comRelated Reading:
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Source: AuntMinnie.com Headlines - January 28, 2020 Category: Radiology Source Type: news
Tired of Delays, U.S. Labs Ask FDA to Develop Their Own Coronavirus Tests Tired of Delays, U.S. Labs Ask FDA to Develop Their Own Coronavirus Tests
U.S. state and local public health laboratories are seeking permission from the Food and Drug Administration to create their own tests for the new coronavirus as manufacturing and regulatory issues continue to delay access to testing capabilities.Reuters Health Information
Source: Medscape Medical News Headlines - February 25, 2020 Category: Consumer Health News Tags: Medscape Today News Source Type: news
Novavax is working to advance a potential coronavirus vaccine. So are competitors.
As the coronavirus spreads, Novavax Inc. is moving forward to find a defense against it.
The Gaithersburg company, which a month ago set out to develop a vaccine for the COVID-19 coronavirus, is now evaluating candidates in animal models — a critical step toward testing in humans. Now Novavax (NASDAQ: NVAX) hopes to receive Food and Drug Administration approval to start human clinic al trials by the end of this spring, it said Wednesday, a fast timeline relative to the yearslong research and development…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - February 26, 2020 Category: Pharmaceuticals Authors: Sara Gilgore Source Type: news
The US has its first novel coronavirus-related drug shortage
The United States has its first novel coronavirus-related drug shortage, according to the US Food and Drug Administration. The maker of an unnamed drug that has recently been added to the FDA Drug Shortages list told the agency that the shortage is due to the novel coronavirus.
Source: CNN.com - Health - February 28, 2020 Category: Consumer Health News Source Type: news
