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Bioactive lipid-based therapeutic approach to COVID-19 and other similar infections
Arch Med Sci. 2021 Apr 23;19(5):1327-1359. doi: 10.5114/aoms/135703. eCollection 2023.ABSTRACTCOVID-19 is caused by SARS-CoV-2 infection. Epithelial and T, NK, and other immunocytes release bioactive lipids especially arachidonic acid (AA) in response to microbial infections to inactivate them and upregulate the immune system. COVID-19 (coronavirus) and other enveloped viruses including severe acute respiratory syndrome (SARS-CoV-1 of 2002-2003) and Middle East respiratory syndrome (MERS; 2012-ongoing) and hepatitis B and C (HBV and HCV) can be inactivated by AA, γ-linolenic acid (GLA, dihomo-GLA (DGLA), eicosapentaenoic ...
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Undurti N Das Source Type: research

Differential transcriptomic changes in the central nervous system and urinary bladders of mice infected with a coronavirus
by Taylor C. Clarkson, Nao Iguchi, Alison Xiaoqiao Xie, Anna P. Malykhina Multiple sclerosis (MS) often leads to the development of neurogenic lower urinary tract symptoms (LUTS). We previously characterized neurogenic bladder dysfunction in a mouse model of MS induced by a coronavirus, mouse hepatitis virus (MHV). The aim of the study was to identify genes and pathways linking neuroinflammation in the central nervous system with urinary bladder (UB) dysfunction to enhance our understanding of the mechanisms underlying LUTS in demyelinating diseases. Adult C57BL/6 male mice (N = 12) received either an intracranial injecti...
Source: PLoS One - December 9, 2022 Category: Biomedical Science Authors: Taylor C. Clarkson Source Type: research

Autoimmune Hepatitis Following Vaccination for SARS-CoV-2 in Korea: Coincidence or Autoimmunity?
We report an AIH case after COVID-19 vaccination in Korea.PMID:35437965 | DOI:10.3346/jkms.2022.37.e116
Source: Journal of Korean Medical Science - April 19, 2022 Category: Biomedical Science Authors: Seong Hee Kang Moon Young Kim Mee Yon Cho Soon Koo Baik Source Type: research

Dermatomyositis Following BNT162b2 mRNA COVID-19 Vaccination
J Korean Med Sci. 2022 Feb 7;37(5):e32. doi: 10.3346/jkms.2022.37.e32.ABSTRACTDermatomyositis (DM) is one of the uncommon multi-organ idiopathic inflammatory myopathies that has been reported following the hepatitis B, Influenza, tetanus toxoid, H1N1, and BCG vaccines. However, an association with the coronavirus disease 2019 (COVID-19) vaccine is yet to be reported. In this case, we present the case of a 43-year-old Asian Indian female who was diagnosed with DM 10 days after receiving the second dosage of BNT162b2 mRNA COVID-19 vaccination, in the absence of any additional triggering factors. The diagnosis was established...
Source: Journal of Korean Medical Science - February 8, 2022 Category: Biomedical Science Authors: Wesam Gouda Anwar Albasri Faisal Alsaqabi Humoud Y Al Sabah Marwan Alkandari Hassan Abdelnaby Source Type: research

Clinical Effect of Hepatitis B Virus on COVID-19 Infected Patients: A Nationwide Population-Based Study Using the Health Insurance Review & amp;amp; Assessment Service Database
CONCLUSION: COVID-19-infected patients with HBV infections showed worse clinical courses than non-HBV-infected COVID-19 patients. However, after adjustment, chronic HBV infection itself does not seem to affect the clinical outcomes in COVID-19 patients.PMID:35075828 | PMC:PMC8787805 | DOI:10.3346/jkms.2022.37.e29
Source: Journal of Korean Medical Science - January 25, 2022 Category: Biomedical Science Authors: Jung Wan Choe Young Kul Jung Hyung Joon Yim Gi Hyeon Seo Source Type: research

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