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Total 84 results found since Jan 2013.

The practice of using repurposed medications as chemoprophylaxis for COVID-19 by healthcare workers in a tertiary hospital in Southern Nigeria
Conclusion: Several HCW in Nigeria take drugs to possibly prevent COVID-19. These medications may not offer significant protection against COVID-19. There is an urgent need to increase uptake of COVID-19 vaccines in HCW in Nigeria.Keywords: COVID-19; chemoprophylaxis; healthcare workers.
Source: African Health Sciences - July 13, 2023 Category: African Health Authors: Sylvanus B Udoette, Asukwo E Onukak, Victor A Umoh, Akpabio A Akpabio Source Type: research

Role of Cytochrome P450 2C9 in COVID-19 Treatment: Current Status and Future Directions
AbstractThe major human liver drug metabolising cytochrome P450 (CYP) enzymes are downregulated during inflammation and infectious disease state, especially during coronavirus disease 2019 (COVID-19) infection. The influx of proinflammatory cytokines, known as a ‘cytokine storm’, during severe COVID-19 leads to the downregulation of CYPs and triggers new cytokine release, which further dampens CYP expression. Impaired drug metabolism, along with the inevitable co-administration of drugs or ‘combination therapy’ in patients with COVID-19 with various comorbidities, could cause drug–drug interactions, thus worsenin...
Source: European Journal of Drug Metabolism and Pharmacokinetics - April 24, 2023 Category: Drugs & Pharmacology Source Type: research

Investigational medications in 9,638 hospitalized patients with severe COVID-19: lessons from the "fail-and-learn" strategy during the first two waves of the pandemic in 2020
CONCLUSION: This retrospective multicenter observational cohort study on 9,638 hospitalized patients with severe COVID-19 during revealed that the necessity for invasive ventilation had the highest odds of mortality, beyond the variable effects observed by administration of the prevalent EUA-approved investigational drugs during the first two surges of the early 2020 pandemic in the United States.PMID:37041643 | PMC:PMC10088131 | DOI:10.1186/s13037-023-00358-9
Source: Patient Safety in Surgery - April 11, 2023 Category: Surgery Authors: Adam C Delgado Brendon Cornett Ye Ji Choi Christina Colosimo Vincent P Stahel Oliwier Dziadkowiec Philip F Stahel Source Type: research

A comprehensive review of therapeutic options for COVID-19
In this study, by investigating some available antimicrobial medicines that may diminish COVID-19 infection, we are trying to introduce a general protocol for controlling this disease.
Source: Ethiopian Journal of Health Development - April 5, 2023 Category: African Health Authors: Mohammad Darvishi, Shahriar Sepahvand, Mohammad Reza Nazer, Hamze Shahali, Mahboobeh Madani, Hassan Sepahvand, Vajihe Karbasizade Source Type: research

Treatment of myasthenia gravis patients with covid-19: review of the literature
Acta Clin Croat. 2022 Feb;60(3):496-509. doi: 10.20471/acc.2021.60.03.21.ABSTRACTCoronavirus disease 2019 (COVID-19), caused by the late 2019 outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes a respiratory disease which could put myasthenia gravis (MG) patients at a greater risk of developing severe disease course, since infections and some drugs are a well-recognized trigger of symptom exacerbation in MG patients. Out of ten most commonly used past and present drugs used in COVID-19 treatment, two (quinolone derivatives and azithromycin) are known to worsen MG symptoms, whereas another two (...
Source: Acta Clinica Croatica - March 14, 2022 Category: General Medicine Authors: Sven Županić Ines Lazibat Maja Rubini ć Majdak Mia Jeli čić Source Type: research

Treatment of myasthenia gravis patients with covid-19: review of the literature
Acta Clin Croat. 2022 Feb;60(3):496-509. doi: 10.20471/acc.2021.60.03.21.ABSTRACTCoronavirus disease 2019 (COVID-19), caused by the late 2019 outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes a respiratory disease which could put myasthenia gravis (MG) patients at a greater risk of developing severe disease course, since infections and some drugs are a well-recognized trigger of symptom exacerbation in MG patients. Out of ten most commonly used past and present drugs used in COVID-19 treatment, two (quinolone derivatives and azithromycin) are known to worsen MG symptoms, whereas another two (...
Source: Acta Clinica Croatica - March 14, 2022 Category: General Medicine Authors: Sven Županić Ines Lazibat Maja Rubini ć Majdak Mia Jeli čić Source Type: research

Treatment of myasthenia gravis patients with covid-19: review of the literature
Acta Clin Croat. 2022 Feb;60(3):496-509. doi: 10.20471/acc.2021.60.03.21.ABSTRACTCoronavirus disease 2019 (COVID-19), caused by the late 2019 outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes a respiratory disease which could put myasthenia gravis (MG) patients at a greater risk of developing severe disease course, since infections and some drugs are a well-recognized trigger of symptom exacerbation in MG patients. Out of ten most commonly used past and present drugs used in COVID-19 treatment, two (quinolone derivatives and azithromycin) are known to worsen MG symptoms, whereas another two (...
Source: Acta Clinica Croatica - March 14, 2022 Category: General Medicine Authors: Sven Županić Ines Lazibat Maja Rubini ć Majdak Mia Jeli čić Source Type: research

Treatment of myasthenia gravis patients with covid-19: review of the literature
Acta Clin Croat. 2022 Feb;60(3):496-509. doi: 10.20471/acc.2021.60.03.21.ABSTRACTCoronavirus disease 2019 (COVID-19), caused by the late 2019 outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes a respiratory disease which could put myasthenia gravis (MG) patients at a greater risk of developing severe disease course, since infections and some drugs are a well-recognized trigger of symptom exacerbation in MG patients. Out of ten most commonly used past and present drugs used in COVID-19 treatment, two (quinolone derivatives and azithromycin) are known to worsen MG symptoms, whereas another two (...
Source: Acta Clinica Croatica - March 14, 2022 Category: General Medicine Authors: Sven Županić Ines Lazibat Maja Rubini ć Majdak Mia Jeli čić Source Type: research

Treatment of myasthenia gravis patients with covid-19: review of the literature
Acta Clin Croat. 2022 Feb;60(3):496-509. doi: 10.20471/acc.2021.60.03.21.ABSTRACTCoronavirus disease 2019 (COVID-19), caused by the late 2019 outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes a respiratory disease which could put myasthenia gravis (MG) patients at a greater risk of developing severe disease course, since infections and some drugs are a well-recognized trigger of symptom exacerbation in MG patients. Out of ten most commonly used past and present drugs used in COVID-19 treatment, two (quinolone derivatives and azithromycin) are known to worsen MG symptoms, whereas another two (...
Source: Acta Clinica Croatica - March 14, 2022 Category: General Medicine Authors: Sven Županić Ines Lazibat Maja Rubini ć Majdak Mia Jeli čić Source Type: research