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Condition: Allergy
Therapy: Corticosteroid Therapy
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Total 120 results found since Jan 2013.
Intranasal steroid use and COVID-19 mortality among patients with asthma and COPD
Systemic corticosteroids have been widely used for treating patients with severe acute respiratory distress syndrome. Inhaled corticosteroids may have a protective effect for treating acute coronavirus disease 2019 (COVID-19); however, little is known about the potential effect of intranasal corticosteroids (INCS) on COVID-19 outcomes and severity.
Source: Annals of Allergy, Asthma and Immunology - July 4, 2023 Category: Allergy & Immunology Authors: Virginia Hernandez Santiago, Adeniyi Francis Fagbamigbe, Frank M Sullivan, Utkarsh Agrawal, Daniel Morales, Colin McCowan, Brian Lipworth Tags: Original Article Source Type: research
Controller therapy attenuates asthma exacerbations associated with prior SARS-CoV-2 infection in children
Abbreviations: Coronavirus disease 2019 (COVID-19); severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), angiotensin-converting enzyme 2 (ACE2), transmembrane serine protease 2 (TMPRSS2), inhaled corticosteroids (ICS), oral corticosteroid (OCS), short-acting beta-agonist (SABA), long-acting beta-agonist (LABA), leukotriene receptor antagonist (LTRA), rate ratios (RR), polymerase chain reaction (PCR)
Source: Annals of Allergy, Asthma and Immunology - June 12, 2023 Category: Allergy & Immunology Authors: Iris Kim, Tricia Morphew, Christine Chou, Louis Ehwerhemuepha, Stanley Galant Tags: Letters Source Type: research
Rates Of Corticosteroid And Antibiotic Prescriptions Are Significantly Increased With Omicron As Compared To Alpha And Delta Variants Of COVID-19 In Patients With Asthma
The novel Coronavirus-19 (COVID-19) pandemic remains ongoing and is complicated by the emergence of new variants. The impact of different variants on asthma is not known although early variants were not associated with increased disease burden in asthmatics. We compared healthcare burden in asthmatics among dominant COVID-19 variants during three time periods, comparing systemic corticosteroid and antibiotic prescriptions.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Elizabeth Kudlaty, Amina Guo, Gayatri Patel, Melissa Watts, Anju Peters Source Type: research
Steroid-induced secondary immune deficiency
Despite their widespread clinical use, oral corticosteroids (OCSs) are well known to be associated with a myriad of adverse effects, including immunosuppression. By inhibiting transcription factors and affecting leukocyte function, prolonged OCS use leads to significant CD4 lymphopenia and often a decrease in serum immunoglobulin (Ig)G. Conversely, OCS use has minimal impact on circulating B cell, serum IgM, or serum IgA levels. Although there is a paucity of literature, individuals treated with prolonged OCS seem to typically maintain humoral response to various vaccinations despite hypogammaglobinemia, but this area warr...
Source: Annals of Allergy, Asthma and Immunology - January 17, 2023 Category: Allergy & Immunology Authors: S. Shahzad Mustafa Tags: Review Source Type: research
β-D-mannuronic Acid (M2000) and Inflammatory Cytokines in COVID-19; An In vitro Study
This study was conducted in vitro on blood samples of 30 COVID-19 patients who presented with ARDS to a referral center. Peripheral blood mononuclear cells (PBMCs) were isolated from blood samples and incubated with phorbol myristate acetate for 24 hours. M2000 was administered with the dosages of 25 µg/well and 50 µg/well after 4 hours of incubation at 37°C. The quantitative real-time polymerase chain reaction (qRT-PCR) was conducted to assess mRNA gene expression. Enzyme-linked immunosorbent assay (ELISA) was performed to evaluate the supernatant PBMC levels of interleukin (IL)-6, IL-17, tumor necrosis factor (TNF)-α...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 14, 2023 Category: Allergy & Immunology Authors: Behrouz Robat-Jazi Khodayar Ghorban Mohammad Gholami Esmaeil Samizadeh Zahra Aghazadeh Mohammad Amin Shahrbaf Maryam Dadmanesh Negin Hosseini Rouzbahani Abbas Mirshafiey Source Type: research
