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Total 706 results found since Jan 2013.
Pathophysiology and clinical management of coronavirus disease (COVID-19): a mini-review
An unprecedented global pandemic caused by a novel coronavirus named SARS-CoV-2 has created a severe healthcare threat and become one of the biggest challenges to human health and the global economy. As of July 2023, over 767 million confirmed cases of COVID-19 have been diagnosed, including more than 6.95 million deaths. The S protein of this novel coronavirus binds to the ACE2 receptor to enter the host cells with the help of another transmembrane protease TMPRSS2. Infected subjects that can mount an appropriate host immune response can quickly inhibit the spread of infection into the lower respiratory system and the dis...
Source: Frontiers in Immunology - August 14, 2023 Category: Allergy & Immunology Source Type: research
A deep learning-based drug repurposing screening and validation for anti-SARS-CoV-2 compounds by targeting the cell entry mechanism
Biochem Biophys Res Commun. 2023 Jul 12;675:113-121. doi: 10.1016/j.bbrc.2023.07.018. Online ahead of print.ABSTRACTThe recent outbreak of Corona Virus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a severe threat to the global public health and economy, however, effective drugs to treat COVID-19 are still lacking. Here, we employ a deep learning-based drug repositioning strategy to systematically screen potential anti-SARS-CoV-2 drug candidates that target the cell entry mechanism of SARS-CoV-2 virus from 2635 FDA-approved drugs and 1062 active ingredients from Tra...
Source: Biochemical and Biophysical Research communications - July 19, 2023 Category: Biochemistry Authors: Yingjia Yao Yunhan Zhang Zexu Li Zhisong Chen Xiaofeng Wang Zihan Li Li Yu Xiaolong Cheng Wei Li Wen-Jie Jiang Hua-Jun Wu Zezhong Feng Jinfu Sun Teng Fei Source Type: research
The Impact of Entry Restrictions on the Spread of Severe Acute Respiratory Syndrome Coronavirus Variants Between 2021 and 2022
This study explored the impact of border policy changes on overseas entrants and local cases of SARS-CoV-2 variants. Data from the Korea Disease Control and Prevention Agency randomly collected between April 11, 2021 and August 20, 2022 were evaluated using the Granger causality model. The results showed that the outbreak gap of delta variants between international and domestic cases was 10 weeks, while that of omicron variants was approximately 2 weeks, meaning that the quarantine policy helped contain delta variants rather than more transmissible variants. It is recommended that countries implement quarantine policies ba...
Source: Journal of Korean Medical Science - July 18, 2023 Category: Biomedical Science Authors: Jinwook Hong Ae Kyung Park Munkhzul Radnaabaatar Eun-Jin Kim Dong Wook Kim Jaehun Jung Source Type: research
