A diagnosis of syphilis following a radical circumcision for suspected penile cancer
We present a case of a 70-year-old gentleman who was referred to our tertiary 2-week-wait penile cancer clinic with a penile mass that was ulcerated, painful and discharging. This was suspicious for penile cancer and a radical circumcision was performed to remove the diseased foreskin en bloc with the lesion that was arising from the inner foreskin. Histopathology did not reveal cancer; however, we identified spirochaetes in keeping with syphilis. This was confirmed on serology. The patient was referred to the genitourinary medicine team and treated with antibiotics. This case demonstrates a rare presentation of genital sy...
Source: Annals of the Royal College of Surgeons of England - April 2, 2024 Category: Surgery Authors: K H Pang A Haider A Freeman P Hadway C Bunker A Muneer H M Alnajjar Source Type: research
A systematic review and meta-analysis of the use of packing in the management of perianal abscesses
CONCLUSIONS: Analysis of the outcomes suggests there is no significant difference with regards to rates of abscess recurrence or fistula formation between the packed and unpacked groups; however, appropriately powered RCTs are required in this area to provide more primary evidence to inform best practice and clinical management.PMID:38563064 | DOI:10.1308/rcsann.2023.0108 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - April 2, 2024 Category: Surgery Authors: D L Crook Ome Padfield Source Type: research
Factors associated with increased radiation exposure in the fixation of proximal femoral fractures
CONCLUSIONS: Increased radiation in proximal femur fractures is seen in the fixation of complex fractures, some subtypes, with certain types of implants used and if an additional implant was required. Surgeon seniority did not result in less radiation exposure, which is in contrast to other published studies.PMID:38563063 | DOI:10.1308/rcsann.2023.0092 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - April 2, 2024 Category: Surgery Authors: A Elbahi O Thomas M Dungey C Randall D K Menon Source Type: research
The genomics of sporadic and hereditary colorectal cancer
Ann R Coll Surg Engl. 2024 Apr;106(4):313-320. doi: 10.1308/rcsann.2024.0024.ABSTRACTColorectal cancer (CRC) is a leading cause of cancer deaths worldwide. Over the past three decades, extensive efforts have sought to elucidate the genomic landscape of CRC. These studies reveal that CRC is highly heterogeneous at the molecular level, with different subtypes characterised by distinct somatic mutational profiles, epigenetic aberrations and transcriptomic signatures. This review summarises our current understanding of the genomic and epigenomic alterations implicated in CRC development and progression. Particular focus is giv...
Source: Annals of the Royal College of Surgeons of England - March 31, 2024 Category: Surgery Authors: I D Sadien R J Davies Jmd Wheeler Source Type: research
Genomic medicine for the 21 < sup > st < /sup > century
Ann R Coll Surg Engl. 2024 Apr;106(4):295-299. doi: 10.1308/rcsann.2024.0030.NO ABSTRACTPMID:38555870 | DOI:10.1308/rcsann.2024.0030 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 31, 2024 Category: Surgery Authors: I Rahman J Barwell Source Type: research
Current and future genomic applications for surgeons
Ann R Coll Surg Engl. 2024 Apr;106(4):321-328. doi: 10.1308/rcsann.2024.0031.ABSTRACTGenomics is a crucial part of managing surgical disease. This review focuses on some of the genomic advances that are available now and looks to the future of their application in surgical practice. Whole-genome sequencing enables unbiased coverage across the entire human genome of approximately three billion base pairs. Newer technologies, such as those that permit long-read sequence analysis, provide additional information in longer phased fragment and base pair epigenomic (methylomic) data. Whole-genome sequencing is currently available...
Source: Annals of the Royal College of Surgeons of England - March 31, 2024 Category: Surgery Authors: O Alkhatib T Miles R P Jones R Mair R Palmer H Winter F D McDermott Source Type: research
Redefining clinical practice through spatial profiling: a revolution in tissue analysis
Ann R Coll Surg Engl. 2024 Apr;106(4):305-312. doi: 10.1308/rcsann.2023.0091.ABSTRACTSpatial biology, which combines molecular biology and advanced imaging, enhances our understanding of tissue cellular organisation. Despite its potential, spatial omics encounters challenges related to data complexity, computational requirements and standardisation of analysis. In clinical applications, spatial omics has the potential to revolutionise biomarker discovery, disease stratification and personalised treatments. It can identify disease-specific cell patterns, and could help risk stratify patients for clinical trials and disease-...
Source: Annals of the Royal College of Surgeons of England - March 31, 2024 Category: Surgery Authors: E J Mulholland S J Leedham Source Type: research
Hereditary genetic testing and mainstreaming: a guide for surgeons
Ann R Coll Surg Engl. 2024 Apr;106(4):300-304. doi: 10.1308/rcsann.2024.0029.NO ABSTRACTPMID:38555867 | DOI:10.1308/rcsann.2024.0029 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 31, 2024 Category: Surgery Authors: A Monaghan E Copson R Cutress Source Type: research
The genomics of sporadic and hereditary colorectal cancer
Ann R Coll Surg Engl. 2024 Apr;106(4):313-320. doi: 10.1308/rcsann.2024.0024.ABSTRACTColorectal cancer (CRC) is a leading cause of cancer deaths worldwide. Over the past three decades, extensive efforts have sought to elucidate the genomic landscape of CRC. These studies reveal that CRC is highly heterogeneous at the molecular level, with different subtypes characterised by distinct somatic mutational profiles, epigenetic aberrations and transcriptomic signatures. This review summarises our current understanding of the genomic and epigenomic alterations implicated in CRC development and progression. Particular focus is giv...
Source: Annals of the Royal College of Surgeons of England - March 31, 2024 Category: Surgery Authors: I D Sadien R J Davies Jmd Wheeler Source Type: research
Genomic medicine for the 21 < sup > st < /sup > century
Ann R Coll Surg Engl. 2024 Apr;106(4):295-299. doi: 10.1308/rcsann.2024.0030.NO ABSTRACTPMID:38555870 | PMC:PMC10981982 | DOI:10.1308/rcsann.2024.0030 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 31, 2024 Category: Surgery Authors: I Rahman J Barwell Source Type: research
Current and future genomic applications for surgeons
Ann R Coll Surg Engl. 2024 Apr;106(4):321-328. doi: 10.1308/rcsann.2024.0031.ABSTRACTGenomics is a crucial part of managing surgical disease. This review focuses on some of the genomic advances that are available now and looks to the future of their application in surgical practice. Whole-genome sequencing enables unbiased coverage across the entire human genome of approximately three billion base pairs. Newer technologies, such as those that permit long-read sequence analysis, provide additional information in longer phased fragment and base pair epigenomic (methylomic) data. Whole-genome sequencing is currently available...
Source: Annals of the Royal College of Surgeons of England - March 31, 2024 Category: Surgery Authors: O Alkhatib T Miles R P Jones R Mair R Palmer H Winter F D McDermott Source Type: research
Redefining clinical practice through spatial profiling: a revolution in tissue analysis
Ann R Coll Surg Engl. 2024 Apr;106(4):305-312. doi: 10.1308/rcsann.2023.0091.ABSTRACTSpatial biology, which combines molecular biology and advanced imaging, enhances our understanding of tissue cellular organisation. Despite its potential, spatial omics encounters challenges related to data complexity, computational requirements and standardisation of analysis. In clinical applications, spatial omics has the potential to revolutionise biomarker discovery, disease stratification and personalised treatments. It can identify disease-specific cell patterns, and could help risk stratify patients for clinical trials and disease-...
Source: Annals of the Royal College of Surgeons of England - March 31, 2024 Category: Surgery Authors: E J Mulholland S J Leedham Source Type: research
Hereditary genetic testing and mainstreaming: a guide for surgeons
Ann R Coll Surg Engl. 2024 Apr;106(4):300-304. doi: 10.1308/rcsann.2024.0029.NO ABSTRACTPMID:38555867 | PMC:PMC10981983 | DOI:10.1308/rcsann.2024.0029 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 31, 2024 Category: Surgery Authors: A Monaghan E Copson R Cutress Source Type: research
Systematic review of survival following liver or lung metastasectomy for metastatic anal squamous cell carcinoma
CONCLUSIONS: The evidence base for metastasectomy in metastatic anal SCC is limited. Further information is required to inform future treatment methods and use of a standardised outcomes reporting method is needed to support this.PMID:38497793 | DOI:10.1308/rcsann.2023.0005 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 18, 2024 Category: Surgery Authors: L Hurt E Barlow M Davies D A Harris C Barrington R L Harries Source Type: research
Surgical outcomes of total duct excision in the diagnosis and management of nipple discharge
CONCLUSIONS: TDE can be considered for the diagnostics and management of nipple discharge. Blood-stained nipple discharge increases the risk of DCIS or malignancy, but the majority of the time TDE reveals benign breast pathology.PMID:38497796 | DOI:10.1308/rcsann.2022.0093 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 18, 2024 Category: Surgery Authors: K Ward G Selvarajah H Al-Omishy M Sait H N Khan K McEvoy S Robertson Source Type: research
