Use Via Early Access to Ixazomib (UVEA-IXA) Study: Effectiveness and Safety of Ixazomib-based Therapy in Relapsed/Refractory Multiple Myeloma Outside of the Clinical Trial Setting
CONCLUSION: This study supports ixazomib-based therapy as an effective and tolerable treatment in the real-world. Outcomes were favorable in patients with 1 or ≥ 2 prior lines of therapy who were not lenalidomide- or PI-refractory.PMID:37996265 | DOI:10.1016/j.clml.2023.10.003 (Source: Clinical Lymphoma and Myeloma)
Source: Clinical Lymphoma and Myeloma - November 23, 2023 Category: Cancer & Oncology Authors: Heinz Ludwig Karthik Ramasamy Mar ía-Victoria Mateos Bhuvan Kishore Varga Gergely Miriam Ladicka Alessandra Ori Lucia Simoni Nawal Bent-Ennakhil Dawn Marie Stull Fran çois Gavini Evangelos Terpos Roman H ájek Source Type: research
Use Via Early Access to Ixazomib (UVEA-IXA) Study: Effectiveness and Safety of Ixazomib-based Therapy in Relapsed/Refractory Multiple Myeloma Outside of the Clinical Trial Setting
CONCLUSION: This study supports ixazomib-based therapy as an effective and tolerable treatment in the real-world. Outcomes were favorable in patients with 1 or ≥ 2 prior lines of therapy who were not lenalidomide- or PI-refractory.PMID:37996265 | DOI:10.1016/j.clml.2023.10.003 (Source: Clinical Lymphoma and Myeloma)
Source: Clinical Lymphoma and Myeloma - November 23, 2023 Category: Cancer & Oncology Authors: Heinz Ludwig Karthik Ramasamy Mar ía-Victoria Mateos Bhuvan Kishore Varga Gergely Miriam Ladicka Alessandra Ori Lucia Simoni Nawal Bent-Ennakhil Dawn Marie Stull Fran çois Gavini Evangelos Terpos Roman H ájek Source Type: research
Stem cell collection after lenalidomide, bortezomib and dexamethasone plus elotuzumab or isatuximab in newly diagnosed multiple myeloma patients: a single centre experience from the GMMG-HD6 and -HD7 trials
While quadruplet induction therapies deepen responses in newly diagnosed multiple myeloma patients, their impact on peripheral blood stem cell (PBSC) collection remains incompletely understood. This analysis a... (Source: BMC Cancer)
Source: BMC Cancer - November 21, 2023 Category: Cancer & Oncology Authors: Joseph Kauer, Emma P. Freundt, Anita Schmitt, Niels Weinhold, Elias K. Mai, Carsten M üller-Tidow, Hartmut Goldschmidt, Marc S. Raab, Katharina Kriegsmann and Sandra Sauer Tags: Research Source Type: research
Hematologists' awareness of venous thromboembolism in multiple myeloma: a national survey in China
CONCLUSION: The results of our study showed that a large proportion of Chinese hematologists failed to recognize the VTE risk factors, most of them cannot select appropriate thromboprophylaxis for different MM therapeutic regimens and lack awareness of stratified thromboprophylaxis for MM-associated VTE. A standard VTE prevention guideline is urgently needed for the Chinese myeloma group. Continuous education for new professionals should be encouraged. A VTE collaborative group is supposed to be established in each hospital to enhance the overall medical care for VTE patients.PMID:37983471 | DOI:10.1080/07853890.2023.22630...
Source: Annals of Medicine - November 20, 2023 Category: Internal Medicine Authors: Qun Li Bo Zhang Qianwen Cheng Fei Zhao Junying Li Han Yan Aoshuang Xu Chunyan Sun Yu Hu Source Type: research
Inhalation Lenalidomide-Loaded Liposome for Bleomycin-Induced Pulmonary Fibrosis Improvement
AAPS PharmSciTech. 2023 Nov 16;24(8):235. doi: 10.1208/s12249-023-02690-w.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a progressive, fibrotic interstitial lung disease with unclear etiology and increasing prevalence. Pulmonary administration can make the drug directly reach the lung lesion location and reduce systemic toxic and side effects. The effectiveness of lenalidomide (Len) liposomal lung delivery in idiopathic pulmonary fibrosis was investigated. Len liposomes (Len-Lip) were prepared from soybean lecithin, cholesterol (Chol), and medicine in different weight ratios by thin film hydration method. The Len-Lip were...
Source: AAPS PharmSciTech - November 16, 2023 Category: Drugs & Pharmacology Authors: Zhilin Luo Liyuan Ji Hongting Liu Yao Sun Conglu Zhao Xiang Xu Xiaoting Gu Xiaoyu Ai Cheng Yang Source Type: research
Inhalation Lenalidomide-Loaded Liposome for Bleomycin-Induced Pulmonary Fibrosis Improvement
AAPS PharmSciTech. 2023 Nov 16;24(8):235. doi: 10.1208/s12249-023-02690-w.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a progressive, fibrotic interstitial lung disease with unclear etiology and increasing prevalence. Pulmonary administration can make the drug directly reach the lung lesion location and reduce systemic toxic and side effects. The effectiveness of lenalidomide (Len) liposomal lung delivery in idiopathic pulmonary fibrosis was investigated. Len liposomes (Len-Lip) were prepared from soybean lecithin, cholesterol (Chol), and medicine in different weight ratios by thin film hydration method. The Len-Lip were...
Source: AAPS PharmSciTech - November 16, 2023 Category: Drugs & Pharmacology Authors: Zhilin Luo Liyuan Ji Hongting Liu Yao Sun Conglu Zhao Xiang Xu Xiaoting Gu Xiaoyu Ai Cheng Yang Source Type: research
Inhalation Lenalidomide-Loaded Liposome for Bleomycin-Induced Pulmonary Fibrosis Improvement
AAPS PharmSciTech. 2023 Nov 16;24(8):235. doi: 10.1208/s12249-023-02690-w.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a progressive, fibrotic interstitial lung disease with unclear etiology and increasing prevalence. Pulmonary administration can make the drug directly reach the lung lesion location and reduce systemic toxic and side effects. The effectiveness of lenalidomide (Len) liposomal lung delivery in idiopathic pulmonary fibrosis was investigated. Len liposomes (Len-Lip) were prepared from soybean lecithin, cholesterol (Chol), and medicine in different weight ratios by thin film hydration method. The Len-Lip were...
Source: AAPS PharmSciTech - November 16, 2023 Category: Drugs & Pharmacology Authors: Zhilin Luo Liyuan Ji Hongting Liu Yao Sun Conglu Zhao Xiang Xu Xiaoting Gu Xiaoyu Ai Cheng Yang Source Type: research
Inhalation Lenalidomide-Loaded Liposome for Bleomycin-Induced Pulmonary Fibrosis Improvement
AAPS PharmSciTech. 2023 Nov 16;24(8):235. doi: 10.1208/s12249-023-02690-w.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a progressive, fibrotic interstitial lung disease with unclear etiology and increasing prevalence. Pulmonary administration can make the drug directly reach the lung lesion location and reduce systemic toxic and side effects. The effectiveness of lenalidomide (Len) liposomal lung delivery in idiopathic pulmonary fibrosis was investigated. Len liposomes (Len-Lip) were prepared from soybean lecithin, cholesterol (Chol), and medicine in different weight ratios by thin film hydration method. The Len-Lip were...
Source: AAPS PharmSciTech - November 16, 2023 Category: Drugs & Pharmacology Authors: Zhilin Luo Liyuan Ji Hongting Liu Yao Sun Conglu Zhao Xiang Xu Xiaoting Gu Xiaoyu Ai Cheng Yang Source Type: research
