Effectiveness of biomedical interventions on the chronic stage of traumatic brain injury: a systematic review of randomized controlled trials
Traumatic brain injury (TBI), in any form and severity, can pose risks for developing chronic symptoms that can profoundly hinder patients’ work/academic, social, and personal lives. In the past 3 decades, a multitude of pharmacological, stimulation, and exercise-based interventions have been proposed to ameliorate symptoms, memory impairment, mental fatigue, and/or sleep disturbances. However, most research is preliminary, thus limited influence on clinical practice. This review aims to systematically appraise the evidence derived from randomized controlled trials (RCT) regarding the effectiveness of pharmacological, st...
Source: Frontiers in Neurology - March 18, 2024 Category: Neurology Source Type: research
Severe Fatigue in Inflammatory Bowel Disease: Dopaminergic Therapy With Modafinil or Vitamin Therapy With Thiamine
We found Moulton et al’s1 illustrative case series of 10 patients with inflammatory bowel disease (IBD) and chronic fatigue, all presenting with depression, particularly interesting. 1 Among the patients, 8 previously had undergone treatment with multiple psychotropic medications, and 2 had active IBD as indicated by increased fecal calprotectin levels. Remarkably, all 10 patients responded positively to open-label treatment with modafinil, a central nervous system stimulant that blocks dopamine reuptake transport, which resulted in an impressive improvement in their fatigue symptoms. At baseline, the self-re ported me...
Source: Clinical Gastroenterology and Hepatology - March 18, 2024 Category: Gastroenterology Authors: Palle Bager, Christian L. Hvas, Jens Frederik Dahlerup Tags: Letters to the Editor Source Type: research
Modafinil, an atypical CNS stimulant?
Adv Pharmacol. 2024;99:287-326. doi: 10.1016/bs.apha.2023.10.006. Epub 2023 Nov 22.ABSTRACTModafinil is a central nervous system stimulant approved for the treatment of narcolepsy and sleep disorders. Due to its wide range of biochemical actions, modafinil has been explored for other potential therapeutic uses. Indeed, it has shown promise as a therapy for cognitive disfunction resulting from neurologic disorders like ADHD, and as a smart drug in non-medical settings. The mechanism(s) of actions underlying the therapeutic efficacy of this agent remains largely elusive. Modafinil is known to inhibit the dopamine transporter...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Melinda Hersey Gianluigi Tanda Source Type: research
Modafinil, an atypical CNS stimulant?
Adv Pharmacol. 2024;99:287-326. doi: 10.1016/bs.apha.2023.10.006. Epub 2023 Nov 22.ABSTRACTModafinil is a central nervous system stimulant approved for the treatment of narcolepsy and sleep disorders. Due to its wide range of biochemical actions, modafinil has been explored for other potential therapeutic uses. Indeed, it has shown promise as a therapy for cognitive disfunction resulting from neurologic disorders like ADHD, and as a smart drug in non-medical settings. The mechanism(s) of actions underlying the therapeutic efficacy of this agent remains largely elusive. Modafinil is known to inhibit the dopamine transporter...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Melinda Hersey Gianluigi Tanda Source Type: research
Modafinil, an atypical CNS stimulant?
Adv Pharmacol. 2024;99:287-326. doi: 10.1016/bs.apha.2023.10.006. Epub 2023 Nov 22.ABSTRACTModafinil is a central nervous system stimulant approved for the treatment of narcolepsy and sleep disorders. Due to its wide range of biochemical actions, modafinil has been explored for other potential therapeutic uses. Indeed, it has shown promise as a therapy for cognitive disfunction resulting from neurologic disorders like ADHD, and as a smart drug in non-medical settings. The mechanism(s) of actions underlying the therapeutic efficacy of this agent remains largely elusive. Modafinil is known to inhibit the dopamine transporter...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Melinda Hersey Gianluigi Tanda Source Type: research
Modafinil, an atypical CNS stimulant?
Adv Pharmacol. 2024;99:287-326. doi: 10.1016/bs.apha.2023.10.006. Epub 2023 Nov 22.ABSTRACTModafinil is a central nervous system stimulant approved for the treatment of narcolepsy and sleep disorders. Due to its wide range of biochemical actions, modafinil has been explored for other potential therapeutic uses. Indeed, it has shown promise as a therapy for cognitive disfunction resulting from neurologic disorders like ADHD, and as a smart drug in non-medical settings. The mechanism(s) of actions underlying the therapeutic efficacy of this agent remains largely elusive. Modafinil is known to inhibit the dopamine transporter...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Melinda Hersey Gianluigi Tanda Source Type: research
Modafinil, an atypical CNS stimulant?
Adv Pharmacol. 2024;99:287-326. doi: 10.1016/bs.apha.2023.10.006. Epub 2023 Nov 22.ABSTRACTModafinil is a central nervous system stimulant approved for the treatment of narcolepsy and sleep disorders. Due to its wide range of biochemical actions, modafinil has been explored for other potential therapeutic uses. Indeed, it has shown promise as a therapy for cognitive disfunction resulting from neurologic disorders like ADHD, and as a smart drug in non-medical settings. The mechanism(s) of actions underlying the therapeutic efficacy of this agent remains largely elusive. Modafinil is known to inhibit the dopamine transporter...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Melinda Hersey Gianluigi Tanda Source Type: research
Modafinil, an atypical CNS stimulant?
Adv Pharmacol. 2024;99:287-326. doi: 10.1016/bs.apha.2023.10.006. Epub 2023 Nov 22.ABSTRACTModafinil is a central nervous system stimulant approved for the treatment of narcolepsy and sleep disorders. Due to its wide range of biochemical actions, modafinil has been explored for other potential therapeutic uses. Indeed, it has shown promise as a therapy for cognitive disfunction resulting from neurologic disorders like ADHD, and as a smart drug in non-medical settings. The mechanism(s) of actions underlying the therapeutic efficacy of this agent remains largely elusive. Modafinil is known to inhibit the dopamine transporter...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Melinda Hersey Gianluigi Tanda Source Type: research
Modafinil, an atypical CNS stimulant?
Adv Pharmacol. 2024;99:287-326. doi: 10.1016/bs.apha.2023.10.006. Epub 2023 Nov 22.ABSTRACTModafinil is a central nervous system stimulant approved for the treatment of narcolepsy and sleep disorders. Due to its wide range of biochemical actions, modafinil has been explored for other potential therapeutic uses. Indeed, it has shown promise as a therapy for cognitive disfunction resulting from neurologic disorders like ADHD, and as a smart drug in non-medical settings. The mechanism(s) of actions underlying the therapeutic efficacy of this agent remains largely elusive. Modafinil is known to inhibit the dopamine transporter...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Melinda Hersey Gianluigi Tanda Source Type: research
Modafinil, an atypical CNS stimulant?
Adv Pharmacol. 2024;99:287-326. doi: 10.1016/bs.apha.2023.10.006. Epub 2023 Nov 22.ABSTRACTModafinil is a central nervous system stimulant approved for the treatment of narcolepsy and sleep disorders. Due to its wide range of biochemical actions, modafinil has been explored for other potential therapeutic uses. Indeed, it has shown promise as a therapy for cognitive disfunction resulting from neurologic disorders like ADHD, and as a smart drug in non-medical settings. The mechanism(s) of actions underlying the therapeutic efficacy of this agent remains largely elusive. Modafinil is known to inhibit the dopamine transporter...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Melinda Hersey Gianluigi Tanda Source Type: research
Modafinil, an atypical CNS stimulant?
Adv Pharmacol. 2024;99:287-326. doi: 10.1016/bs.apha.2023.10.006. Epub 2023 Nov 22.ABSTRACTModafinil is a central nervous system stimulant approved for the treatment of narcolepsy and sleep disorders. Due to its wide range of biochemical actions, modafinil has been explored for other potential therapeutic uses. Indeed, it has shown promise as a therapy for cognitive disfunction resulting from neurologic disorders like ADHD, and as a smart drug in non-medical settings. The mechanism(s) of actions underlying the therapeutic efficacy of this agent remains largely elusive. Modafinil is known to inhibit the dopamine transporter...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Melinda Hersey Gianluigi Tanda Source Type: research
Modafinil, an atypical CNS stimulant?
Adv Pharmacol. 2024;99:287-326. doi: 10.1016/bs.apha.2023.10.006. Epub 2023 Nov 22.ABSTRACTModafinil is a central nervous system stimulant approved for the treatment of narcolepsy and sleep disorders. Due to its wide range of biochemical actions, modafinil has been explored for other potential therapeutic uses. Indeed, it has shown promise as a therapy for cognitive disfunction resulting from neurologic disorders like ADHD, and as a smart drug in non-medical settings. The mechanism(s) of actions underlying the therapeutic efficacy of this agent remains largely elusive. Modafinil is known to inhibit the dopamine transporter...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Melinda Hersey Gianluigi Tanda Source Type: research
Modafinil, an atypical CNS stimulant?
Adv Pharmacol. 2024;99:287-326. doi: 10.1016/bs.apha.2023.10.006. Epub 2023 Nov 22.ABSTRACTModafinil is a central nervous system stimulant approved for the treatment of narcolepsy and sleep disorders. Due to its wide range of biochemical actions, modafinil has been explored for other potential therapeutic uses. Indeed, it has shown promise as a therapy for cognitive disfunction resulting from neurologic disorders like ADHD, and as a smart drug in non-medical settings. The mechanism(s) of actions underlying the therapeutic efficacy of this agent remains largely elusive. Modafinil is known to inhibit the dopamine transporter...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Melinda Hersey Gianluigi Tanda Source Type: research
Modafinil, an atypical CNS stimulant?
Adv Pharmacol. 2024;99:287-326. doi: 10.1016/bs.apha.2023.10.006. Epub 2023 Nov 22.ABSTRACTModafinil is a central nervous system stimulant approved for the treatment of narcolepsy and sleep disorders. Due to its wide range of biochemical actions, modafinil has been explored for other potential therapeutic uses. Indeed, it has shown promise as a therapy for cognitive disfunction resulting from neurologic disorders like ADHD, and as a smart drug in non-medical settings. The mechanism(s) of actions underlying the therapeutic efficacy of this agent remains largely elusive. Modafinil is known to inhibit the dopamine transporter...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Melinda Hersey Gianluigi Tanda Source Type: research
Modafinil, an atypical CNS stimulant?
Adv Pharmacol. 2024;99:287-326. doi: 10.1016/bs.apha.2023.10.006. Epub 2023 Nov 22.ABSTRACTModafinil is a central nervous system stimulant approved for the treatment of narcolepsy and sleep disorders. Due to its wide range of biochemical actions, modafinil has been explored for other potential therapeutic uses. Indeed, it has shown promise as a therapy for cognitive disfunction resulting from neurologic disorders like ADHD, and as a smart drug in non-medical settings. The mechanism(s) of actions underlying the therapeutic efficacy of this agent remains largely elusive. Modafinil is known to inhibit the dopamine transporter...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Melinda Hersey Gianluigi Tanda Source Type: research
