Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities
This study examined the most recent evidence on the efficacy and safety of several therapeutic options available including natural substances, synthetic drugs and vaccines in the treatment of COVID-19. Various natural compounds such as sarsapogenin, lycorine, biscoclaurine, vitamin B12, glycyrrhizic acid, riboflavin, resveratrol and kaempferol, various vaccines and drugs such as AZD1222, mRNA-1273, BNT162b2, Sputnik V, and remdesivir, lopinavir, favipiravir, darunavir, oseltamivir, and umifenovir, resp., have been discussed comprehensively. We attempted to provide exhaustive information regarding the various prospective th...
Source: Acta Pharmaceutica - June 12, 2023 Category: Drugs & Pharmacology Authors: Sijia Fan Hongling Wang Dean Wu Lu Liu Source Type: research

Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities
This study examined the most recent evidence on the efficacy and safety of several therapeutic options available including natural substances, synthetic drugs and vaccines in the treatment of COVID-19. Various natural compounds such as sarsapogenin, lycorine, biscoclaurine, vitamin B12, glycyrrhizic acid, riboflavin, resveratrol and kaempferol, various vaccines and drugs such as AZD1222, mRNA-1273, BNT162b2, Sputnik V, and remdesivir, lopinavir, favipiravir, darunavir, oseltamivir, and umifenovir, resp., have been discussed comprehensively. We attempted to provide exhaustive information regarding the various prospective th...
Source: Acta Pharmaceutica - June 12, 2023 Category: Drugs & Pharmacology Authors: Sijia Fan Hongling Wang Dean Wu Lu Liu Source Type: research

Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities
This study examined the most recent evidence on the efficacy and safety of several therapeutic options available including natural substances, synthetic drugs and vaccines in the treatment of COVID-19. Various natural compounds such as sarsapogenin, lycorine, biscoclaurine, vitamin B12, glycyrrhizic acid, riboflavin, resveratrol and kaempferol, various vaccines and drugs such as AZD1222, mRNA-1273, BNT162b2, Sputnik V, and remdesivir, lopinavir, favipiravir, darunavir, oseltamivir, and umifenovir, resp., have been discussed comprehensively. We attempted to provide exhaustive information regarding the various prospective th...
Source: Acta Pharmaceutica - June 12, 2023 Category: Drugs & Pharmacology Authors: Sijia Fan Hongling Wang Dean Wu Lu Liu Source Type: research

Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities
This study examined the most recent evidence on the efficacy and safety of several therapeutic options available including natural substances, synthetic drugs and vaccines in the treatment of COVID-19. Various natural compounds such as sarsapogenin, lycorine, biscoclaurine, vitamin B12, glycyrrhizic acid, riboflavin, resveratrol and kaempferol, various vaccines and drugs such as AZD1222, mRNA-1273, BNT162b2, Sputnik V, and remdesivir, lopinavir, favipiravir, darunavir, oseltamivir, and umifenovir, resp., have been discussed comprehensively. We attempted to provide exhaustive information regarding the various prospective th...
Source: Acta Pharmaceutica - June 12, 2023 Category: Drugs & Pharmacology Authors: Sijia Fan Hongling Wang Dean Wu Lu Liu Source Type: research

Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities
This study examined the most recent evidence on the efficacy and safety of several therapeutic options available including natural substances, synthetic drugs and vaccines in the treatment of COVID-19. Various natural compounds such as sarsapogenin, lycorine, biscoclaurine, vitamin B12, glycyrrhizic acid, riboflavin, resveratrol and kaempferol, various vaccines and drugs such as AZD1222, mRNA-1273, BNT162b2, Sputnik V, and remdesivir, lopinavir, favipiravir, darunavir, oseltamivir, and umifenovir, resp., have been discussed comprehensively. We attempted to provide exhaustive information regarding the various prospective th...
Source: Acta Pharmaceutica - June 12, 2023 Category: Drugs & Pharmacology Authors: Sijia Fan Hongling Wang Dean Wu Lu Liu Source Type: research

Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities
This study examined the most recent evidence on the efficacy and safety of several therapeutic options available including natural substances, synthetic drugs and vaccines in the treatment of COVID-19. Various natural compounds such as sarsapogenin, lycorine, biscoclaurine, vitamin B12, glycyrrhizic acid, riboflavin, resveratrol and kaempferol, various vaccines and drugs such as AZD1222, mRNA-1273, BNT162b2, Sputnik V, and remdesivir, lopinavir, favipiravir, darunavir, oseltamivir, and umifenovir, resp., have been discussed comprehensively. We attempted to provide exhaustive information regarding the various prospective th...
Source: Acta Pharmaceutica - June 12, 2023 Category: Drugs & Pharmacology Authors: Sijia Fan Hongling Wang Dean Wu Lu Liu Source Type: research

Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities
This study examined the most recent evidence on the efficacy and safety of several therapeutic options available including natural substances, synthetic drugs and vaccines in the treatment of COVID-19. Various natural compounds such as sarsapogenin, lycorine, biscoclaurine, vitamin B12, glycyrrhizic acid, riboflavin, resveratrol and kaempferol, various vaccines and drugs such as AZD1222, mRNA-1273, BNT162b2, Sputnik V, and remdesivir, lopinavir, favipiravir, darunavir, oseltamivir, and umifenovir, resp., have been discussed comprehensively. We attempted to provide exhaustive information regarding the various prospective th...
Source: Acta Pharmaceutica - June 12, 2023 Category: Drugs & Pharmacology Authors: Sijia Fan Hongling Wang Dean Wu Lu Liu Source Type: research

Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities
This study examined the most recent evidence on the efficacy and safety of several therapeutic options available including natural substances, synthetic drugs and vaccines in the treatment of COVID-19. Various natural compounds such as sarsapogenin, lycorine, biscoclaurine, vitamin B12, glycyrrhizic acid, riboflavin, resveratrol and kaempferol, various vaccines and drugs such as AZD1222, mRNA-1273, BNT162b2, Sputnik V, and remdesivir, lopinavir, favipiravir, darunavir, oseltamivir, and umifenovir, resp., have been discussed comprehensively. We attempted to provide exhaustive information regarding the various prospective th...
Source: Acta Pharmaceutica - June 12, 2023 Category: Drugs & Pharmacology Authors: Sijia Fan Hongling Wang Dean Wu Lu Liu Source Type: research

Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities
This study examined the most recent evidence on the efficacy and safety of several therapeutic options available including natural substances, synthetic drugs and vaccines in the treatment of COVID-19. Various natural compounds such as sarsapogenin, lycorine, biscoclaurine, vitamin B12, glycyrrhizic acid, riboflavin, resveratrol and kaempferol, various vaccines and drugs such as AZD1222, mRNA-1273, BNT162b2, Sputnik V, and remdesivir, lopinavir, favipiravir, darunavir, oseltamivir, and umifenovir, resp., have been discussed comprehensively. We attempted to provide exhaustive information regarding the various prospective th...
Source: Acta Pharmaceutica - June 12, 2023 Category: Drugs & Pharmacology Authors: Sijia Fan Hongling Wang Dean Wu Lu Liu Source Type: research

Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities
This study examined the most recent evidence on the efficacy and safety of several therapeutic options available including natural substances, synthetic drugs and vaccines in the treatment of COVID-19. Various natural compounds such as sarsapogenin, lycorine, biscoclaurine, vitamin B12, glycyrrhizic acid, riboflavin, resveratrol and kaempferol, various vaccines and drugs such as AZD1222, mRNA-1273, BNT162b2, Sputnik V, and remdesivir, lopinavir, favipiravir, darunavir, oseltamivir, and umifenovir, resp., have been discussed comprehensively. We attempted to provide exhaustive information regarding the various prospective th...
Source: Acta Pharmaceutica - June 12, 2023 Category: Drugs & Pharmacology Authors: Sijia Fan Hongling Wang Dean Wu Lu Liu Source Type: research

Maintenance darunavir/ritonavir monotherapy to prevent perinatal HIV transmission, ANRS-MIE 168 MONOGEST study
ConclusionsDarunavir/ritonavir maintenance monotherapy required intensification in nearly 10% of cases. This limits its widespread use, thus other regimens should be evaluated in order to limit exposure to antiretrovirals, particularly NRTIs, during pregnancy. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 30, 2023 Category: Microbiology Source Type: research

PRESTIGIO RING: "A 59-year-old HIV-1 positive, highly treatment-experienced woman failing darunavir/ ritonavir plus raltegravir"
New Microbiol. 2023 May;46(2):226-230.ABSTRACTManagement of heavily treatment experienced (HTE) people with HIV remains a challenge. Tailored antiretroviral therapy (ART) is needed in this fragile population who almost invariably harbor viral quasispecies with resistance-associated mutations (RAMs). The reference method for HIV genotypic resistance testing (GRT) has long been Sanger sequencing (SS), but next-generation sequencing (NGS), following recent progress in workflow and cost-effectiveness, is replacing SS because of higher sensitivity. From the PRESTIGIO Registry, we present a case of a 59-year-old HTE woman who fa...
Source: New Microbiologica - May 29, 2023 Category: Microbiology Authors: Laura Labate Bianca Bruzzone Vincenzo Spagnuolo Maurizio Zazzi Maria Mercedes Santoro Antonio Di Biagio Antonella Castagna Source Type: research