CRADLE-5: a stepped-wedge type 2 hybrid implementation-effectiveness cluster randomised controlled trial to evaluate the real-world scale-up of the CRADLE Vital Signs Alert intervention into routine maternity care in Sierra Leone —study protocol
DiscussionInternational guidance recommends that all pregnant and postpartum women have regular blood pressure assessment, and healthcare staff are adequately trained to respond to abnormalities. Clinical effectiveness to improve maternal and perinatal health in more rural areas, and ease of integration and sustainability of the CRADLE intervention at scale has yet to be investigated. This trial will explore whether national scale-up of the CRADLE intervention reduces maternal and fetal mortality and severe maternal adverse outcomes and understand the strategies for adoption, integration and sustainability in low-resource ...
Source: Trials - September 15, 2023 Category: Research Source Type: clinical trials
A treatment strategy with nifedipine versus labetalol for women with pregnancy hypertension: study protocol for a randomised controlled trial (Giant PANDA)
DiscussionThis trial aims to address the uncertainty of which antihypertensive treatment is associated with optimal maternal and neonatal outcomes. The trial results are intended to provide definitive evidence to inform guidelines and linked, shared decision-making tools, thus influencing clinical practice.Trial registrationEudraCT number: 2020 –003410-12, ISRCTN: 12,792,616 registered on 18 November 2020. (Source: Trials)
Source: Trials - September 12, 2023 Category: Research Source Type: clinical trials
Hydroxychloroquine May be Beneficial for Preeclampsia
Condition: Pre-Eclampsia Intervention: Drug: Hydroxychloroquine Sponsor: RenJi Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 31, 2023 Category: Research Source Type: clinical trials
