A novel method for interpreting survival analysis data: description and test on three major clinical trials on cardiovascular prevention
ConclusionsWith our novel method, by exploiting original Kaplan-Meier curves from three major clinical trials on cardiovascular prevention, we generate new information on the actual consequences of choosing a therapeutic strategy vs another, thus ultimately providing the clinical gain in terms of time-dependent functions. Accurately assessing clinically and economic meaningful results from any intervention trial reporting positive results through this approach, facilitates objective comparisons and increases reliability in predicting survival among the various therapeutic options provided.Trial registrationPROVE-IT (Pravas...
Source: Trials - June 25, 2020 Category: Research Source Type: clinical trials
Evaluation of Pharmacokinetic Interaction Between GSK3640254 and Caffeine, Metoprolol, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin in Healthy Adults
Condition: HIV Infections Interventions: Drug: GSK3640254 200 mg; Drug: Caffeine 200 mg; Drug: Metoprolol 100 mg; Drug: Montelukast 10 mg; Drug: Flurbiprofen 100 mg; Drug: Omeprazole 40 mg; Drug: Midazolam 5 mg (2.5 mL); Drug: Digoxin 0.25 mg; Drug: Pravastatin 40 mg Sponsor: ViiV Healthcare Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - June 12, 2020 Category: Research Source Type: clinical trials
