Safety, Tolerability and Pharmacokinetics of NYX-783 and Oxycodone DDI Study
Condition: Opioid Use Disorder Interventions: Drug: NYX-783; Drug: Placebo; Drug: Oxycodone Sponsors: Yale University; National Institute on Drug Abuse (NIDA) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 7, 2022 Category: Research Source Type: clinical trials
Parasternal After Cardiac Surgery (PACS): a prospective, randomised, double-blinded, placebo-controlled trial study protocol for evaluating a continuous bilateral parasternal block with lidocaine after open cardiac surgery through sternotomy
This study aims to determine whether a continuous bilateral parasternal block with lidocaine, which is a short-acting local anaesthetic that has a favourable safety/toxicity profile, results in effective analgesia. We hypothesise that a 72-hour continuous parasternal block with 0.5% lidocaine at a rate of 7 ml/hour on each side provides effective analgesia and reduces opioid requirement. We will evaluate whether recovery is enhanced.MethodsIn a prospective, randomised, double-blinded manner, 45 patients will receive a continuous parasternal block with either 0.5% lidocaine or saline. The primary endpoint is cumulated intra...
Source: Trials - June 20, 2022 Category: Research Source Type: clinical trials
Influence on study outcomes of an inpatient study by the behavior of the study staff (PINgPOng): study protocol for a randomized clinical trial
DiscussionThe PINgPOng study will allow to answer the question whether and to what extent the behavior of a trained study team (neutral vs. maximize vs. minimize placebo responses) will differentially affect placebo responses in a setting of a highly standardized early clinical trial. The results will help to control the placebo effects by education of the clinical study team and to avoid unnecessary high placebo effects in clinical development.Trial registrationGerman Clinical Trials RegisterDRKS00013586. Registered on December 22, 2017. (Source: Trials)
Source: Trials - June 13, 2022 Category: Research Source Type: clinical trials
