Efficacy of acupuncture based on acupoint combination theory for irritable bowel syndrome: a study protocol for a multicenter randomized controlled trial
This study aims to investigate the efficacy and safety of acupuncture therapy for IBS patients compared with those of conventional treatments. We also aim to identify the optimal acupoint combination recommended for IBS and to clarify the clinical advantage of the “multiacupoint co-effect and synergistic effect.”Methods and analysisA total of 204 eligible patients who meet the Rome IV criteria for IBS will be randomly stratified into acupuncture group A, acupuncture group B, or the control group in a 1:1:1 ratio with a central web-based randomization system. The prespecified acupoints used in the control group will inc...
Source: Trials - October 19, 2021 Category: Research Source Type: clinical trials
Prophylactic potential of honey and Nigella sativa L. against hospital and community-based SARS-CoV-2 spread: a structured summary of a study protocol for a randomised controlled trial
AbstractObjectivesConsidering the therapeutic potential of honey and Nigella sativa (HNS) in coronavirus disease 2019 (COVID-19) patients, the objective of the study is defined to evaluate the prophylactic role of HNS.Trial designThe study is a randomized, placebo-controlled, adaptive clinical trial with parallel group design, superiority framework with an allocation ratio of 1:1 among experimental (HNS) and placebo group. An interim analysis will be done when half of the patients have been recruited to evaluate the need to adapt sample size, efficacy, and futility of the trial.ParticipantsAll asymptomatic patients with ho...
Source: Trials - September 15, 2021 Category: Research Source Type: clinical trials
Rapid deployment of a community engagement study and educational trial via social media: implementation of the UC-COVID study
ConclusionsWe demonstrate that rapid recruitment into a longitudinal intervention trial via social media is feasible, efficient, and acceptable. Recruitment in conjunction with community partners representing target populations, and with outreach across multiple platforms, is recommended to optimize sample size and diversity. Trial implementation, engagement tracking, and retention are feasible with off-the-shelf tools using preexisting platforms.Trial registrationClinicalTrials.govNCT04373135. Registered on May 4, 2020 (Source: Trials)
Source: Trials - August 2, 2021 Category: Research Source Type: clinical trials
The Threshold of Serum Anion Gap as a Screening Tool for Organic Acidosis
Conditions: Metabolic Acidosis; Critical Illness; Anion Gap Acidosis; Lactic Acidosis; Keto Acidosis; Acid Base Disorder Intervention: Sponsor: Changi General Hospital Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 26, 2021 Category: Research Source Type: clinical trials
